Abstract: An isolated IgG antibody includes two identical heavy chains each having a hinge region with an amino acid sequence containing an additional cysteine upstream of the two cysteines in the CPPCP sequence of a native IgG hinge region, and a CH1 domain containing a cysteine at the position of 142 according to the IMGT numbering scheme. ADCs based on the antibody having this architecture are also provided.

Abstract: A system and method for preparing epoxy chloropropane is provided in that by coupling three stages of high gravity reactors, the product epoxy chloropropane and water vapor are distilled from a reaction system in form of an azeotrope by adopting a water vapor steam stripping method. Further, by combining the azeotrope with the multiples stages of high gravity reactors, the gas phase mass transfer and the liquid phase mass transfer of the azeotrope are improved aiming at the features of the azeotrope in the reaction system, thus making the overall conversion rate higher. In addition, by combining steam stripping and high gravity, dichloropropanol and alkali solution are rapidly mixed for mass transfer, and the product epoxy chloropropane is rapidly distilled from the reaction system in the form of the azeotrope, such that the reaction proceeds continuously towards the direction of producing epoxy chloropropane, thus significantly improving the conversion rate.

Abstract: An aerosol generating product includes an aerosol atomizing element and a smoke cooling element, and the smoke cooling element is located downstream of the flow direction of the smoke generated by the aerosol atomizing element. A filter element is located downstream of the flow direction of the smoke through which the smoke cooling element passes; or a hollow element located upstream of the flow direction of the smoke through which the smoke cooling element passes. The smoke cooling element is composed of particles, and the structure includes a gap for smoke of a cigarette to pass through. The gap through which cigarette smoke can pass is a three-dimensional and non-linear gap. The structure is in the form of rods. When the smoke aerosol passes through the cooling element, ensuring the smoke to pass through smoothly.

Abstract: A cellulose acetate particle aggregate, a preparation method therefor and an application thereof, which relate to the field of harm reduction additives in cigarettes. The cellulose acetate particle aggregate includes 49-99.5 wt % of cellulose acetate particles, 0-50 wt % of a second kind of particles, and 0.5-20 wt % of a binder. The preparation method involves selecting cellulose acetate particles and a second kind of particles in a certain ratio, or cellulose acetate particles alone, preparing particle aggregates by using an air fluidized granulation method while adding a binder thereto, and sieving the particle aggregates to obtain a cellulose acetate particle aggregate having a required particle size. The cellulose acetate particle aggregate has a porous structure, an irregular shape, and a rough and uneven surface, which help to improve the efficiency of filtering out particulate matters or one or more harmful ingredients in cigarette smoke.

Abstract: A cellulose acetate particle aggregate, a preparation method therefor and an application thereof, which relate to the field of harm reduction additives in cigarettes. The cellulose acetate particle aggregate includes 49-99.5 wt % of cellulose acetate particles, 0-50 wt % of a second kind of particles, and 0.5-20 wt % of a binder. The preparation method involves selecting cellulose acetate particles and a second kind of particles in a certain ratio, or cellulose acetate particles alone, preparing particle aggregates by using an air fluidized granulation method while adding a binder thereto, and sieving the particle aggregates to obtain a cellulose acetate particle aggregate having a required particle size. The cellulose acetate particle aggregate has a porous structure, an irregular shape, and a rough and uneven surface, which help to improve the efficiency of filtering out particulate matters or one or more harmful ingredients in cigarette smoke.

Abstract: The invention relates to a crosslinkable acrylate polymer composition comprising a first polymer having Tg of 50 to 100° C. and a second polymer having Tg of ?10 to 25° C., wherein the composition has an acid number of 1-30 mg KOH/g, or the composition has an acid number of 1-39 mg KOH/g and at least one of the first polymer and the second polymer comprises 0.1-5 wt % of monomer units having a crosslinkable functional group based on the weight of the composition, and a primer prepared thereof. The invention also relates to use of said primer for preparing beer bottle label paper.

Abstract: The present invention is directed to a colloidal (meth)acrylic polymer emulsion, wherein the (meth)acrylic polymer has a weight average molecular weight of 3000 to 8000 daltons, Tg of 110 to 140° C. and an acid value of 150 to 240 mgKOH/g. The present invention also provide a water-based hot stamping primer coating which comprises the colloidal (meth)acrylic polymer emulsion. The present invention further provides a hot stamping film comprising a hot stamping primer formed from the water-based hot stamping primer coating.

Abstract: A cellulose acetate particle aggregate, a preparation method therefor and an application thereof, which relate to the field of harm reduction additives in cigarettes. The cellulose acetate particle aggregate includes 49-99.5 wt % of cellulose acetate particles, 0-50 wt % of a second kind of particles, and 0.5-20 wt % of a binder. The preparation method involves selecting cellulose acetate particles and a second kind of particles in a certain ratio, or cellulose acetate particles alone, preparing particle aggregates by using an air fluidized granulation method while adding a binder thereto, and sieving the particle aggregates to obtain a cellulose acetate particle aggregate having a required particle size. The cellulose acetate particle aggregate has a porous structure, an irregular shape, and a rough and uneven surface, which help to improve the efficiency of filtering out particulate matters or one or more harmful ingredients in cigarette smoke.

Abstract: The invention relates to a crosslinkable acrylate polymer composition comprising a first polymer having Tg of 50 to 100° C. and a second polymer having Tg of ?10 to 25° C., wherein the composition has an acid number of 1-30 mg KOH/g, or the composition has an acid number of 1-39 mg KOH/g and at least one of the first polymer and the second polymer comprises 0.1-5 wt % of monomer units having a crosslinkable functional group based on the weight of the composition, and a primer prepared thereof. The invention also relates to use of said primer for preparing beer bottle label paper.

Abstract: The invention describes a preparation process of pressure sensitive adhesives, wherein a multi-stage emulsifier-free emulsion polymerization and applications of the obtained dispersions for pressure sensitive protective films are included. At least one carboxylic acid group containing monomer is used in the first stage of emulsion polymerization. The theoretical glass transition temperatures are lower than 0° C. (for the first stage polymer), ?20° C. (for the second stage polymer) and ?15° C. (for the overall dispersion), respectively. The dispersion is preferably cross-linked with polyfunctional crosslinking agents, such as aziridine, isocyanate, carbodiimide and oxazoline. The adhesives obtained from the process thereof can be used for the application of protective films to reduce or eliminate ghost shadow on the protected surfaces.