Abstract: The present disclosure provides assays, such as lateral flow assays, and components thereof for detection of an analyte, e.g., a neutralizing antibody, that blocks binding of a first molecular component and a second molecular component of a molecular binding pair. In some embodiments, the disclosed assays and components thereof enable the rapid detection of a SARS-CoV-2 neutralizing antibody in a sample from an individual. Also provided in other aspects of the disclosure are devices, methods of making and using, and kits of the assays described herein.

Abstract: The present disclosure provides assays, such as lateral flow assays, and components thereof for detection of an analyte, e.g., a neutralizing antibody, that blocks binding of a first molecular component and a second molecular component of a molecular binding pair. In some embodiments, the disclosed assays and components thereof enable the rapid detection of a SARS-CoV-2 neutralizing antibody in a sample from an individual. Also provided in other aspects of the disclosure are devices, methods of making and using, and kits of the assays described herein.

Abstract: The present disclosure provides assays, such as lateral flow assays, and components thereof for detection of an analyte, e.g., a neutralizing antibody, that blocks binding of a first molecular component and a second molecular component of a molecular binding pair. In some embodiments, the disclosed assays and components thereof enable the rapid detection of a SARS-CoV-2 neutralizing antibody in a sample from an individual. Also provided in other aspects of the disclosure are devices, methods of making and using, and kits of the assays described herein.

Abstract: The present disclosure provides devices for processing, such as staining, a tissue sample on a microscope slide. In some embodiments, the tissue staining device described herein is capable of, e.g., automating, in whole or in part, a tissue staining protocol (including a chemical staining protocol and/or an immuno-based staining protocol) or a tissue dehydration protocol. Also provided in other aspects of the disclosure are components, methods of use, systems, and kits associated with the devices described herein.

Abstract: The present disclosure provides methods, kits, and compositions for direct immunohistochemical (IHC) staining and direct immunocytochemistry (ICC) techniques, including applications to multiplex assays, chemically stained samples, and cytology samples.

Abstract: Some embodiments of the present application provide a method for synchronizing data and device, the method including: after receiving each source data transmitted from each source database within a current cycle, the management device calculates according to correlative relationships among the source databases and according to a plurality of data records included in each source data to obtain a target data set, and transmits the target data set to each data sink. In embodiments of the present application, the management device just needs to implement the calculation process, and performs the calculation of the target data set during the synchronization process, so that data sinks may directly acquire the target data set, which significantly reduces the computational amount of the entire system and improves timeliness of data synchronization.

Abstract: The present invention relates generally to sets of digital antibodies directed against short epitopes, and use thereof in methods for protein analysis.

Abstract: The present invention provides expression vectors that facilitate high levels of expression of GPCR proteins. Encompassed by the invention are methods and compositions for recombinant cell lines expressing GPCR proteins with the aid of the expression vectors of the instant invention. The recombinant cell lines of the instant invention express GPCR proteins at levels of at least about 150,000 copies of the protein per cell. The present invention also provides methods and compositions for raising antibodies against GPCR proteins using the high expressing recombinant cells of the instant invention.