Patents by Inventor Jianfu Zhou

Jianfu Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptides selective for Bcl-2 family proteins
    Patent number: 11286299
    Abstract: Provided herein are peptides selective for combinations of Mcl-1/Bfl-1/Bcl-xL. Also provided are compositions containing these polypeptides and methods of using such peptides in the treatment of cancer that include administering to a subject one of the polypeptides.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: March 29, 2022
    Assignees: Massachusetts Institute of Technology, Trustees of Darthmouth College
    Inventors: Vincent Xue, Justin Michael Jenson, Amy E. Keating, Jianfu Zhou, Gevorg Grigoryan
  • COMPUTATIONAL PROTEIN DESIGN USING TERTIARY OR QUATERNARY STRUCTURAL MOTIFS
    Publication number: 20210210159
    Abstract: This disclosure relates to a method for constructing an amino acid sequence or a library of amino acid sequences capable of folding into pre-defined structure or into a binding partner of a target structure. The method is based on the concept that protein structure space is modular, composed of highly recurrent structural building blocks.
    Type: Application
    Filed: May 30, 2019
    Publication date: July 8, 2021
    Inventors: Gevorg Grigoryan, Jianfu Zhou, Craig Mackenzie
  • PEPTIDES SELECTIVE FOR BCL-2 FAMILY PROTEINS
    Publication number: 20200262914
    Abstract: Provided herein are peptides selective for combinations of Mcl-1/Bfl-1/Bc1-xL. Also provided are compositions containing these polypeptides and methods of using such peptides in the treatment of cancer that include administering to a subject one of the polypeptides.
    Type: Application
    Filed: September 17, 2019
    Publication date: August 20, 2020
    Inventors: Vincent Xue, Justin Michael Jenson, Amy E. Keating, Jianfu Zhou, Gevorg Grigoryan