Abstract: A fluid property sensing array includes a first sensor including a first electrode assembly and a first sensing layer at least partially coating the first electrode assembly, the first sensor having a first response to a property of the fluid; and a second sensor including a second electrode assembly and a second sensing layer at least partially coating the second electrode assembly, the second sensor having a second response to the property of the fluid. The array can include a third sensor including a third electrode assembly and a third sensing layer at least partially coating the third electrode assembly, the third sensor having a third response to the property of the fluid. The first sensing layer, the second sensing layer, and the third sensing layer can be compositionally different, such that the first response, the second response, and the third response to the property of the fluid are different.

Abstract: A wearable inductive-force sensor, which provides high-sensitivity dynamic measurements of both normal force and shear force, utilizes three spiral planar force sensing coils. These spiral planar coils allow the measurement of shear force in the x and y directions and the measurement of a normal force in the z direction. The force sensor is configured to be mounted in various locations, such as an insole of a shoe, so as to provide real-time force sensing of forces that are applied to a patient's feet as they move. In addition, force-measurement electronics used with the force sensor are configured to use resonance-frequency division signal multiplexing to monitor the response of the force sensing coils, which allows the sensor to have minimal complexity, while still being highly sensitive.

Abstract: Exemplary embodiments of the present disclosure provide for two-stage microfluidic devices using surface acoustic waves, methods of use thereof, methods of making, methods of focusing and separating particles, and the like.

Abstract: A prosthesis includes a socket for receiving a residual limb, the socket having a socket wall defining a limb-receiving surface; a heat pipe including a working fluid and a wicking structure, the heat pipe having a socket section and a heat sink section, the heat pipe extending along its length through the socket wall proximate to or exposed at the limb-receiving surface, wherein the working fluid has a boiling point of from about 0° C. to 90° C. such that the working fluid is adapted to evaporate to form vapor under the influence of the heat of a residual limb in the socket thus drawing heat from and cooling the residual limb. A heat sink section of the heat pipe passes through the heat sink, the heat sink reducing the temperature of the working fluid.

Abstract: An apparatus for detecting wear particles in a fluid includes an inlet channel and an outlet channel. An ultrasonic transducer creating an acoustic wave that defines an acoustic focal zone is located between the inlet and outlet channels. A flow path located between the inlet and outlet channel is shaped to restrict the flow of the fluid to be within the acoustic focal zone. An inductive pulse sensor includes a plurality of flow channels receiving the fluid and a plurality of planar coils wound around the flow channels. The inductive pulse sensor includes a detection system for the detection of wear particles passing through the flow channels based on a change in an electrical property of the planar coils. A single combined excitation signal is sent to all the planar coils at once and the detection system measures one single output measurement for the plurality of flow channels.

Abstract: A high sensitivity inductive sensor for measuring clearance of a rotating blade tip includes a one or more of sensing coils. The sensing coils are formed of magnet wire, which is wound to form planar spiral coils. Each of the coils are coupled in series with a function generator, which applies an excitation signal thereto. Accordingly, based on the change in impedance of the coils, a clearance measurement, which identifies the distance between the coil and the tip of the rotating blade can be obtained using predetermined calibration curve values.

Abstract: In various aspects and embodiments, the present invention is directed to versatile, label-free method for the quantitative and qualitative detection of biomarkers and/or other compounds in a fluid sample using functionalized microparticle aggregates. In these methods, micron-scale particles are functionalized to specifically interact with the biomarker being measured and added to the sample to form aggregates, the size and number of which are counted to find a volume fraction and/or number fraction of aggregates in the sample. There is a direct correlation between the volume fraction and number fraction of these aggregates and the concentration of the corresponding biomarker. By comparing the measured volume fraction and/or number fraction of aggregates in the sample to a calibration curve, the concentration of that biomarker may be determined even for biomarkers or other target compounds in samples at very low concentrations, without the need for fluorescence and enzyme labelling of antibodies.

Abstract: A prosthesis includes a socket for receiving a residual limb, the socket having a socket wall defining a limb-receiving surface; a heat pipe including a working fluid and a wicking structure, the heat pipe having a socket section and a heat sink section, the heat pipe extending along its length through the socket wall proximate to or exposed at the limb-receiving surface, wherein the working fluid has a boiling point of from about 0° C. to 90° C. such that the working fluid is adapted to evaporate to form vapor under the influence of the heat of a residual limb in the socket thus drawing heat from and cooling the residual limb. A heat sink section of the heat pipe passes through the heat sink, the heat sink reducing the temperature of the working fluid.

Abstract: A high sensitivity inductive sensor for measuring clearance of a rotating blade tip includes a one or more of sensing coils. The sensing coils are formed of magnet wire, which is wound to form planar spiral coils. Each of the coils are coupled in series with a function generator, which applies an excitation signal thereto. Accordingly, based on the change in impedance of the coils, a clearance measurement, which identifies the distance between the coil and the tip of the rotating blade can be obtained using predetermined calibration curve values.

Abstract: A wearable inductive-force sensor, which provides high-sensitivity dynamic measurements of both normal force and shear force, utilizes three spiral planar force sensing coils. These spiral planar coils allow the measurement of shear force in the x and y directions and the measurement of a normal force in the z direction. The force sensor is configured to be mounted in various locations, such as an insole of a shoe, so as to provide real-time force sensing of forces that are applied to a patient's feet as they move. In addition, force-measurement electronics used with the force sensor are configured to use resonance-frequency division signal multiplexing to monitor the response of the force sensing coils, which allows the sensor to have minimal complexity, while still being highly sensitive.

Abstract: An apparatus for detecting wear particles in a fluid includes an inlet channel and an outlet channel. An ultrasonic transducer creating an acoustic wave that defines an acoustic focal zone is located between the inlet and outlet channels. A flow path located between the inlet and outlet channel is shaped to restrict the flow of the fluid to be within the acoustic focal zone. An inductive pulse sensor includes a plurality of flow channels receiving the fluid and a plurality of planar coils wound around the flow channels. The inductive pulse sensor includes a detection system for the detection of wear particles passing through the flow channels based on a change in an electrical property of the planar coils. A single combined excitation signal is sent to all the planar coils at once and the detection system measures one single output measurement for the plurality of flow channels.

Abstract: In one embodiment, a system for manipulation of a micro component includes a gripper subsystem for lifting, holding, and releasing a micro component. The gripper subsystem includes a base substrate having a work side and an opposing side, a positive electrode secured to the work side of the base substrate, a negative electrode suitably spaced from the positive electrode and secured to the work side of the base substrate, a dielectric layer formed over the work side of the base substrate and the positive and negative electrodes, and a hydrophobic layer comprising a hydrophobic material with predictable electrowetting behavior formed over the dielectric layer such that the dielectric layer is between the work side of the base substrate and the hydrophobic layer. A method for manipulation of a micro component is also provided as well as a method of manufacturing the system for manipulation of a micro component.

Abstract: Exemplary embodiments of the present disclosure provide for two-stage microfluidic devices using surface acoustic waves, methods of use thereof, methods of making, methods of focusing and separating particles, and the like.

Abstract: An apparatus and a method for detection of wear particles in a lubricant are disclosed. The apparatus includes a microfluidic device including a microchannel sized for a lubricant containing wear particles to pass therethrough and first and second electrodes extending into the microchannel. A detection system is coupled with the electrodes for detection of wear particles passing through the microchannel, based on a change in capacitance of the electrodes.

Abstract: In one embodiment, a system for manipulation of a micro component includes a gripper subsystem for lifting, holding, and releasing a micro component. The gripper subsystem includes a base substrate having a work side and an opposing side, a positive electrode secured to the work side of the base substrate, a negative electrode suitably spaced from the positive electrode and secured to the work side of the base substrate, a dielectric layer formed over the work side of the base substrate and the positive and negative electrodes, and a hydrophobic layer comprising a hydrophobic material with predictable electrowetting behavior formed over the dielectric layer such that the dielectric layer is between the work side of the base substrate and the hydrophobic layer. A method for manipulation of a micro component is also provided as well as a method of manufacturing the system for manipulation of a micro component.

Abstract: The present invention generally relates to a method for rapidly counting micron and/or submicron particles by passing such particles through any of a plurality of microfluidic channels simultaneously with an ion current and measuring the signal generated thereby. The present invention also generally relates to a device for practicing the method of the present invention. Some embodiments can include methods and/or devices for distinguishing between and counting particles in mixtures. Still other embodiments can include methods and/or devices for identifying and/or counting bioparticles and/or bioactive particles such as pollen.

Abstract: An apparatus and a method for detection of wear particles in a lubricant are disclosed. The apparatus includes a microfluidic device including a microchannel sized for a lubricant containing wear particles to pass therethrough and first and second electrodes extending into the microchannel. A detection system is coupled with the electrodes for detection of wear particles passing through the microchannel, based on a change in capacitance of the electrodes.

Abstract: The present invention generally relates to a method for rapidly counting micron and/or submicron particles by passing such particles through any of a plurality of microfluidic channels simultaneously with an ion current and measuring the signal generated thereby. The present invention also generally relates to a device for practicing the method of the present invention. Some embodiments can include methods and/or devices for distinguishing between and counting particles in mixtures. Still other embodiments can include methods and/or devices for identifying and/or counting bioparticles and/or bioactive particles such as pollen.

Abstract: The present invention generally relates to a method for rapidly counting micron and/or submicron particles by passing such particles through any of a plurality of orifices simultaneously with an ion current and measuring the signal generated thereby. The present invention also generally relates to a device for practicing the method of the present invention. Some embodiments can include methods and/or devices for distinguishing between and counting particles in mixtures. Still other embodiments can include methods and/or devices for identifying and/or counting bioparticles and/or bioactive particles such as pollen.

Abstract: The present invention generally relates to a method for rapidly counting micron and/or submicron particles by passing such particles through any of a plurality of orifices simultaneously with an ion current and measuring the signal generated thereby. The present invention also generally relates to a device for practicing the method of the present invention. Some embodiments can include methods and/or devices for distinguishing between and counting particles in mixtures. Still other embodiments can include methods and/or devices for identifying and/or counting bioparticles and/or bioactive particles such as pollen.