Patents by Inventor Jiangbo Yu

Jiangbo Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220252607
    Abstract: The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.
    Type: Application
    Filed: February 15, 2022
    Publication date: August 11, 2022
    Inventors: Daniel T. Chiu, Changfeng Wu, Jason McNeill, Jiangbo Yu
  • Patent number: 11408884
    Abstract: Lyophilized chromophoric polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions, methods of dispersing the lyophilized compositions in aqueous solutions and kits supplying the compositions.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: August 9, 2022
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Daniel T. Chiu, Wei Sun, Jiangbo Yu, Changfeng Wu, Fangmao Ye
  • Publication number: 20220082566
    Abstract: The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
    Type: Application
    Filed: November 30, 2021
    Publication date: March 17, 2022
    Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Daniel T. Chiu, Changfeng Wu, Jiangbo Yu
  • Patent number: 11249086
    Abstract: The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: February 15, 2022
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Daniel T. Chiu, Changfeng Wu, Jason McNeill, Jiangbo Yu
  • Patent number: 11249073
    Abstract: The present disclosure provides metal-containing (MC) semiconducting (SC) Pdots (MC-SC-Pdots) with beneficial functionalities in both cellular imaging and manipulation, among other applications. The Pdots comprise at least one nanoparticle comprising at least one metal, and a semiconducting polymer associated with the nanoparticle.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: February 15, 2022
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Daniel T. Chiu, Wei Sun, Jiangbo Yu, Changfeng Wu
  • Publication number: 20220025111
    Abstract: Polymers, monomers, narrow-band absorbing polymers, narrow-band absorbing monomers, absorbing units, polymer dots, and related methods are provided. Bright, luminescent polymer nanoparticles with narrow-band absorptions are provided. Methods for synthesizing absorbing monomers, methods for synthesizing the polymers, preparation methods for forming the polymer nanoparticles, and applications for using the polymer nanoparticles are also provided.
    Type: Application
    Filed: September 16, 2019
    Publication date: January 27, 2022
    Applicant: University of Washington
    Inventors: Daniel T. Chiu, Lei Chen, Jiangbo Yu
  • Patent number: 11221336
    Abstract: The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: January 11, 2022
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Daniel T. Chiu, Changfeng Wu, Jiangbo Yu
  • Publication number: 20210343445
    Abstract: The present disclosure provides organic-inorganic hybrid polymer particles, which have desirable surface chemistry and optical properties that make them particularly suitable for biological and optical applications. The present disclosure also provides methods of making organic-inorganic hybrid polymer particles. The present disclosure also provides methods of using the organic-inorganic hybrid polymer particles for biological and optical applications.
    Type: Application
    Filed: July 6, 2021
    Publication date: November 4, 2021
    Applicant: University of Washington
    Inventors: Daniel T. CHIU, Jiangbo YU, Yu RONG, Changfeng WU
  • Patent number: 11087900
    Abstract: The present disclosure provides organic-inorganic hybrid polymer particles, which have desirable surface chemistry and optical properties that make them particularly suitable for biological and optical applications. The present disclosure also provides methods of making organic-inorganic hybrid polymer particles. The present disclosure also provides methods of using the organic-inorganic hybrid polymer particles for biological and optical applications.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: August 10, 2021
    Assignee: University of Washington
    Inventors: Daniel T. Chiu, Jiangbo Yu, Yu Rong, Changfeng Wu
  • Patent number: 10983130
    Abstract: This disclosure provides semiconducting polymer dots (Pdots) for use in a wide variety of applications. In particular, this disclosure provides Pdots that are halogenated, including fluorinated Pdots. This disclosure also provides methods for synthesizing Pdots and methods for using Pdots, such as for biological imaging.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: April 20, 2021
    Assignee: University of Washington Through Its Center for Commercialization
    Inventors: Daniel Chiu, Yong Zhang, Jiangbo Yu, Yu Rong
  • Publication number: 20200371109
    Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
    Type: Application
    Filed: August 10, 2020
    Publication date: November 26, 2020
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Daniel T. Chiu, Changfeng Wu, Xuanjun Zhang, Jiangbo Yu, Fangmao Ye
  • Publication number: 20200362391
    Abstract: Methods, devices, and systems for performing digital assays are provided. In certain aspects, the methods, devices, and systems can be used for the detection of nucleic acids and proteins. Also provided are methods, devices, systems, and compositions for improved detection and quantification of target molecules using encoded probes. In certain aspects, the methods, devices, and systems provided herein are useful in multiplexed digital assays. In certain aspects, the methods, devices, and systems can be used for the recognition, detection, and sizing of compartmentalized volumes in a volume. Also provided are compositions and kits suitable for use with the methods and devices of the present disclosure.
    Type: Application
    Filed: November 1, 2018
    Publication date: November 19, 2020
    Inventors: Daniel T. CHIU, Jiangbo YU, Jason E. KREUTZ, Jiasi WANG
  • Publication number: 20200312481
    Abstract: The present disclosure provides organic-inorganic hybrid polymer particles, which have desirable surface chemistry and optical properties that make them particularly suitable for biological and optical applications. The present disclosure also provides methods of making organic-inorganic hybrid polymer particles. The present disclosure also provides methods of using the organic-inorganic hybrid polymer particles for biological and optical applications.
    Type: Application
    Filed: June 12, 2020
    Publication date: October 1, 2020
    Inventors: Daniel T. CHIU, Jiangbo YU, Yu RONG, Changfeng WU
  • Patent number: 10770197
    Abstract: The present disclosure provides organic-inorganic hybrid polymer particles, which have desirable surface chemistry and optical properties that make them particularly suitable for biological and optical applications. The present disclosure also provides methods of making organic-inorganic hybrid polymer particles. The present disclosure also provides methods of using the organic-inorganic hybrid polymer particles for biological and optical applications.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: September 8, 2020
    Assignee: University of Washington
    Inventors: Daniel T. Chiu, Jiangbo Yu, Yu Rong, Changfeng Wu
  • Patent number: 10739349
    Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: August 11, 2020
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Daniel T. Chiu, Changfeng Wu, Xuanjun Zhang, Jiangbo Yu, Fangmao Ye
  • Publication number: 20200158724
    Abstract: Lyophilized chromophoric polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions, methods of dispersing the lyophilized compositions in aqueous solutions and kits supplying the compositions.
    Type: Application
    Filed: December 3, 2019
    Publication date: May 21, 2020
    Inventors: Daniel T. CHIU, Wei SUN, Jiangbo YU, Changfeng WU, Fangmao YE
  • Patent number: 10656073
    Abstract: Methods of optically marking and sorting adherent cells are provided. The methods include providing a plurality of adherent cells attached to a substrate, each adherent cell of the plurality of adherent cells having an optical marker. The methods also include selectively applying light energy to a subset of the plurality of adherent cells, and detaching the plurality of adherent cells from the substrate. These methods also provide the sorting of the plurality of adherent cells.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: May 19, 2020
    Assignee: University of Washington
    Inventors: Daniel T. Chiu, Chun-Ting Kuo, Jiangbo Yu
  • Publication number: 20200011874
    Abstract: The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
    Type: Application
    Filed: August 29, 2019
    Publication date: January 9, 2020
    Inventors: Daniel T. Chiu, Changfeng Wu, Jiangbo Yu
  • Publication number: 20200005960
    Abstract: The present disclosure provides organic-inorganic hybrid polymer particles, which have desirable surface chemistry and optical properties that make them particularly suitable for biological and optical applications. The present disclosure also provides methods of making organic-inorganic hybrid polymer particles. The present disclosure also provides methods of using the organic-inorganic hybrid polymer particles for biological and optical applications.
    Type: Application
    Filed: June 13, 2017
    Publication date: January 2, 2020
    Inventors: Daniel T. CHIU, Jiangbo YU, Yu RONG, Changfeng WU
  • Patent number: 10514381
    Abstract: Lyophilized chromophoric polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions, methods of dispersing the lyophilized compositions in aqueous solutions and kits supplying the compositions.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: December 24, 2019
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Daniel T. Chiu, Wei Sun, Jiangbo Yu, Changfeng Wu, Fangmao Ye