Patents by Inventor Jianghang Xie

Jianghang Xie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Caspase-3-triggered molecular self-assembling PET probes and uses thereof
    Patent number: 11679168
    Abstract: Embodiments of the synthesis, radiolabeling and biological applications of an activatable tracer that undergoes intramolecular cyclization and aggregation upon activation by cleavage of a blocking moiety are provided. The probes of the disclosure allow for target-controlled self-assembly of small molecules in living subjects for imaging and drug delivery. The aggregated nanoprobes of the disclosure may be detectable optically, by PET detection, magnetic resonance imaging, and the like depending on the detectable reporter attached to the nanoprobe.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: June 20, 2023
    Assignee: The Board of Trustees of Leland Stanford Junior University
    Inventors: Jianghong Rao, Yunfeng Cheng, Min Chen, Jianghang Xie, Zixin Chen
  • CASPASE-3-TRIGGERED MOLECULAR SELF-ASSEMBLING PET PROBES AND USES THEREOF
    Publication number: 20200085980
    Abstract: Embodiments of the synthesis, radiolabeling and biological applications of an activatable tracer that undergoes intramolecular cyclization and aggregation upon activation by cleavage of a blocking moiety are provided. The probes of the disclosure allow for target-controlled self-assembly of small molecules in living subjects for imaging and drug delivery. The aggregated nanoprobes of the disclosure may be detectable optically, by PET detection, magnetic resonance imaging, and the like depending on the detectable reporter attached to the nanoprobe.
    Type: Application
    Filed: September 13, 2019
    Publication date: March 19, 2020
    Inventors: Jianghong Rao, Yunfeng Cheng, Min Chen, Jianghang Xie, Zixin Chen