Abstract: The invention discloses a multi-channel high-precision ADC circuit with self-calibration of mismatch error, belonging to the technical field of integrated circuit. The multi-channel high-precision ADC circuit with self-calibration of mismatch error comprises a gain error compensation circuit, a clock phase error compensation circuit, an N-bit analog-digital converter of M-channel, a gain error quantization circuit, a clock phase error quantization circuit and a control circuit. The multi-channel high-precision ADC circuit with self-calibration of mismatch error can automatically choose the calibration precision according to system precision and hardware overhead, and has the characteristic of low power consumption.