Abstract: The present application discloses a device and a method for testing an omnidirectional anisotropic permeability tensor, and relates to the technical field of core testing devices. The device includes a core holder and a spherical core, and is provided with a simulated wellbore passing through the spherical core. The spherical core rotates with the simulated wellbore. A flow guide tube and a plurality of liquid flow channels are also provided on the core holder. When in use, the omnidirectional anisotropy measurement for the core permeability can be achieved by rotating the spherical core and changing the liquid flow channels, thereby completing the measurement of the core permeability tensor.