Patents by Inventor Jiangong LU

Jiangong LU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12275763
    Abstract: The present invention discloses a RamA transcription factor mutant for promoting the production of N-acetylglucosamine and use thereof. The mutant is obtained by mutating lysine at position 90 to asparagine and serine at position 92 to lysine in a parent having an amino acid sequence as shown in SEQ ID NO: 2. The present invention provides a genetically engineered strain that overexpresses the RamA transcription factor mutant and increases the production of N-acetylglucosamine. By overexpressing the transcription factor RamA that is involved in the regulation of carbon metabolism, the extracellular accumulation of N-acetylglucosamine is increased, with a maximum concentration reaching 31.5 g/L, which lays a foundation for further metabolic engineering of Corynebacterium glutamicum to produce glucosamine. The method for constructing recombinant Corynebacterium glutamicum of the invention is simple, and convenient in use, and thus has good application prospects.
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: April 15, 2025
    Assignees: JIANGNAN UNIVERSITY, SHANDONG RUNDE BIOTECHNOLOGY CO., LTD.
    Inventors: Long Liu, Jian Chen, Xueqin Lv, Jianxing Lu, Changfeng Liu, Guocheng Du, Jianghua Li, Chen Deng, Jiangong Lu
  • Patent number: 11512319
    Abstract: The present invention provides a recombinant Corynebacterium glutamicum producing N-acetylglucosamine and use thereof. The recombinant Corynebacterium glutamicum is obtained by overexpressing, in Corynebacterium glutamicum, the transcription factor SugR derived therefrom. The recombinant Corynebacterium glutamicum of the present invention increases the production of acetylglucosamine to up to 26 g/L, and lays a foundation for further metabolic engineering of Corynebacterium glutamicum to produce glucosamine.
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: November 29, 2022
    Assignees: JIANGNAN UNIVERSITY, SHANDONG RUNDE BIOTECHNOLOGY CO., LTD.
    Inventors: Jianxing Lu, Long Liu, Jian Chen, Changfeng Liu, Xueqin Lv, Guocheng Du, Jianghua Li, Chen Deng, Jiangong Lu
  • Publication number: 20220106366
    Abstract: The present invention discloses a RamA transcription factor mutant for promoting the production of N-acetylglucosamine and use thereof. The mutant is obtained by mutating lysine at position 90 to asparagine and serine at position 92 to lysine in a parent having an amino acid sequence as shown in SEQ ID NO: 2. The present invention provides a genetically engineered strain that overexpresses the RamA transcription factor mutant and increases the production of N-acetylglucosamine. By overexpressing the transcription factor RamA that is involved in the regulation of carbon metabolism, the extracellular accumulation of N-acetylglucosamine is increased, with a maximum concentration reaching 31.5 g/L, which lays a foundation for further metabolic engineering of Corynebacterium glutamicum to produce glucosamine. The method for constructing recombinant Corynebacterium glutamicum of the invention is simple, and convenient in use, and thus has good application prospects.
    Type: Application
    Filed: January 7, 2020
    Publication date: April 7, 2022
    Inventors: Long LIU, Jian CHEN, Xueqin LV, Jianxing LU, Changfeng LIU, Guocheng DU, Jianghua LI, Chen DENG, Jiangong LU
  • Publication number: 20220090101
    Abstract: The present invention provides a recombinant Corynebacterium glutamicum producing N-acetylglucosamine and use thereof. The recombinant Corynebacterium glutamicum is obtained by overexpressing, in Corynebacterium glutamicum, the transcription factor SugR derived therefrom. The recombinant Corynebacterium glutamicum of the present invention increases the production of acetylglucosamine to up to 26 g/L, and lays a foundation for further metabolic engineering of Corynebacterium glutamicum to produce glucosamine.
    Type: Application
    Filed: January 7, 2020
    Publication date: March 24, 2022
    Inventors: Jianxing LU, Long LIU, Jian CHEN, Changfeng LIU, Xueqin LV, Guocheng DU, Jianghua LI, Chen DENG, Jiangong LU