Abstract: Various embodiments include processing devices and methods for relocation and reinitialization for a robotic device. Various embodiments may include concurrently relocating a second pose of the robotic device and reinitializing a third pose of the robotic device in response to failing to determine a first pose of the robotic device in the environment and determining that tracking of the robotic device is lost. Various embodiments may include pre-relocating a second pose of the robotic device in the environment in response to failing to determine the first pose of the robotic device in the environment and determining that tracking of the robotic device is lost, relocating a third pose of the robotic device in response to successfully pre-relocating the second pose of the robotic device, and reinitializing a fourth pose of the robotic device in response to unsuccessfully pre-relocating the second pose of the robotic device.

Abstract: The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of TCR ? chain, TCR ? chain, beta-2 microglobulin and FAS further comprising a nucleic acid encoding a modified T cell receptor (TCR) comprising affinity for a surface antigen on a target cell or an electroporated nucleic acid encoding a chimeric antigen receptor (CAR). Also included are methods and pharmaceutical compositions comprising the modified T cell for adoptive therapy and treating a condition, such as an autoimmune disease.

Abstract: The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of TCR ? chain, TCR ? chain, beta-2 microglobulin and FAS further comprising a nucleic acid encoding a modified T cell receptor (TCR) comprising affinity for a surface antigen on a target cell or an electroporated nucleic acid encoding a chimeric antigen receptor (CAR). Also included are methods and pharmaceutical compositions comprising the modified T cell for adoptive therapy and treating a condition, such as an autoimmune disease.

Abstract: The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of TCR ? chain, TCR ? chain, beta-2 microglobulin and FAS further comprising a nucleic acid encoding a modified T cell receptor (TCR) comprising affinity for a surface antigen on a target cell or an electroporated nucleic acid encoding a chimeric antigen receptor (CAR). Also included are methods and pharmaceutical compositions comprising the modified T cell for adoptive therapy and treating a condition, such as an autoimmune disease.

Abstract: The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of TCR ? chain, TCR ? chain, beta-2 microglobulin and FAS further comprising a nucleic acid encoding a modified T cell receptor (TCR) comprising affinity for a surface antigen on a target cell or an electroporated nucleic acid encoding a chimeric antigen receptor (CAR). Also included are methods and pharmaceutical compositions comprising the modified T cell for adoptive therapy and treating a condition, such as an autoimmune disease.

Abstract: Various embodiments include processing devices and methods for initializing an image sensor of a robotic vehicle. In some embodiments, a processor of the robotic vehicle may extract first features from a captured image of the target image, may extract second features from a predefined image pyramid of the target image, may match first features and second features, and may estimate an image sensor pose based on matched features and known dimensions of the target image. In some embodiments, the processor may estimate an image or to image sensor pose based on matched features and a translation and/or rotation of the robotic vehicle. In some embodiments, the processor may determine a coordinate system for the robotic vehicle based on one or more image sensor poses.

Abstract: Embodiments include devices and methods for processing an image captured by an image sensor of an unmanned autonomous vehicle (UAV). A processor of the UAV may determine a body coordinate matrix of the UAV. The processor may determine an estimated rotation of the image sensor of the UAV. The processor may determine an estimated rotation of the UAV. The processor may transform an image captured by the image sensor based on the body coordinate matrix, the estimated rotation of the image sensor, and the estimated rotation of the UAV.

Abstract: The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of TCR ? chain, TCR ? chain, beta-2 microglobulin, a HLA molecule, CTLA-4, PD1, and FAS and further comprising a nucleic acid encoding a modified T cell receptor (TCR) comprising affinity for a surface antigen on a target cell or an electroporated nucleic acid encoding a chimeric antigen receptor (CAR). Also included are methods and pharmaceutical compositions comprising the modified T cell for adoptive therapy and treating a condition, such as an autoimmune disease.

Abstract: Embodiments include devices and methods for adaptive image processing in an unmanned autonomous vehicle (UAV). In various embodiments, an image sensor may capture an image, while a processor of the UAV obtains attitude information from one or more attitude sensors. Such information may include the relative attitude of the UAV and changes in attitude. The processor of the UAV may determine a UAV motion mode based, at least in part, on the obtained attitude information. The UAV motion mode may result in the modification of yaw correction parameters. The processor of the UAV may further execute yaw filtering on the image based, at least in part, on the determined motion mode.

Abstract: The present invention relates to modified T cells with reduced or abolished TCR/CD3 complex expression, and the methods to produce the same. Also included are pharmaceutical compositions comprising the modified T cell for adoptive therapy and treating a condition, such as cancer, infections or autoimmune diseases.

Abstract: The present invention relates to engineered chimeric guide RNAs and their uses in systems and methods for gene expression perturbation in eukaryotic cells. Furthermore, the invention also relates to methods for generating a modified T cell using the engineered chimeric guide RNAs of the present application, and to the obtained modified T cell. Also included are methods and pharmaceutical compositions comprising the modified T cell for adoptive therapy and treating a condition, such as cancer, infections or autoimmune diseases.

Abstract: Various embodiments include processing devices and methods for relocation and reinitialization for a robotic device. Various embodiments may include concurrently relocating a second pose of the robotic device and reinitializing a third pose of the robotic device in response to failing to determine a first pose of the robotic device in the environment and determining that tracking of the robotic device is lost. Various embodiments may include pre-relocating a second pose of the robotic device in the environment in response to failing to determine the first pose of the robotic device in the environment and determining that tracking of the robotic device is lost, relocating a third pose of the robotic device in response to successfully pre-relocating the second pose of the robotic device, and reinitializing a fourth pose of the robotic device in response to unsuccessfully pre-relocating the second pose of the robotic device.

Abstract: Various embodiments include processing devices and methods for navigation of a robotic vehicle. Various embodiments may include a rearward-facing image sensor mounted such that its plane angle aligns with a navigation plane of the robotic vehicle. In various embodiments, the image sensor of the robotic vehicle may capture images and a processor of the robotic vehicle may execute simultaneous localization and mapping (SLAM) tracking using the captured images. Embodiments may include a processor of the robotic vehicle determining whether the robotic vehicle is approaching a barrier. If the robotic vehicle is approaching a barrier, the processor may determine whether a rotation angle of the image sensor of the robotic vehicle exceeds a rotation threshold. If the rotation angle exceeds the rotation threshold then the processor may determine whether SLAM tracking is stable; and reinitialize a pose of the robotic vehicle in response to determining that SLAM tracking is not stable.

Abstract: Various embodiments include processing devices and methods for initializing an image sensor of a robotic vehicle. In some embodiments, a processor of the robotic vehicle may extract first features from a captured image of the target image, may extract second features from a predefined image pyramid of the target image, may match first features and second features, and may estimate an image sensor pose based on matched features and known dimensions of the target image. In some embodiments, the processor may estimate an image or to image sensor pose based on matched features and a translation and/or rotation of the robotic vehicle. In some embodiments, the processor may determine a coordinate system for the robotic vehicle based on one or more image sensor poses.

Abstract: Various embodiments include processing devices and methods for classifying areas close to the robotic vehicle as feature-rich or feature-poor based, at least in part, on identified environmental features. A processor may select a target position based, at least in part, on the classified areas and the path costs, and initiate movement of the robotic vehicle toward the selected target position. Occasionally during transition of the robotic vehicle, the processor may determine whether the robotic vehicle has reached the target position and in response to determining that the robotic vehicle has not reached the target position, the processor may adjust the robotic vehicle's trajectory. For example, the processor may perform localization of the robotic vehicle based, at least in part, on the classified areas and may also modify a path of the robotic vehicle to the target position based, at least in part, on the localization and the classified areas.

Abstract: Various embodiments include methods for improving navigation by a processor of a robotic device. Such embodiments may include initiating a start of a predetermined time period associated with semantic information extraction, and determining whether an adverse event related to one or more sensors of the robotic device is detected. Such embodiments may also include identifying a current time slot of the predetermined time period, identifying a current estimated position and orientation of the robotic device, and recording updates to semantic information stored for the one or more sensor based on the identified current time slot and the current estimated position and orientation of the robotic device in response to determining that an adverse event related to one or more sensors of the robotic device is detected.

Abstract: The present invention includes compositions and methods for modifying primary T cells. In one aspect, the invention comprises administering to a cell a stem-loop Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) RNA (st-crRNA) and a Cpf1 enzyme.

Abstract: The present disclosure provides gene edited modified immune cells or precursors thereof (e.g., gene edited modified T cells) comprising an exogenous T cell receptor (TCR) and/or a chimeric antigen receptor (CAR) having specificity for a target antigen, and an insertion and/or deletion in one or more endogenous gene loci, wherein the endogenous gene loci encode regulators of T cell function, thereby resulting in immune cells having enhanced function. Compositions and methods of treatment are also provided. The present invention provides methods of screening for TCR- or CAR-T cells with enhanced immune function (e.g., T cell efficacy, T cell memory, and/or T cell persistence).

Abstract: Embodiments include devices and methods for processing an image captured by an image sensor of an unmanned autonomous vehicle (UAV). A processor of the UAV may determine a body coordinate matrix of the UAV. The processor may determine an estimated rotation of the image sensor of the UAV. The processor may determine an estimated rotation of the UAV. The processor may transform an image captured by the image sensor based on the body coordinate matrix, the estimated rotation of the image sensor, and the estimated rotation of the UAV.

Abstract: Embodiments include devices and methods for adaptive image processing in an unmanned autonomous vehicle (UAV). In various embodiments, an image sensor may capture an image, while a processor of the UAV obtains attitude information from one or more attitude sensors. Such information may include the relative attitude of the UAV and changes in attitude. The processor of the UAV may determine a UAV motion mode based, at least in part, on the obtained attitude information. The UAV motion mode may result in the modification of yaw correction parameters. The processor of the UAV may further execute yaw filtering on the image based, at least in part, on the determined motion mode.