Patents by Inventor Jianguo Yang

Jianguo Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11963970
    Abstract: The present disclosure discloses a preparation method of ginseng composition with high ginsenoside bioavailability. The composition is composed of ginseng powder of 250 meshes or more and ?-cyclodextrin, and the mass ratio of the ginseng powder to the ?-cyclodextrin is 1:0.05. Results show that when ?-cyclodextrin is used as a solid dispersant and added to the 1000-mesh ginseng powder at a mass ratio of 5%, the total dissolution amount is maximum; and furthermore, animal experiments (SD rats) show that the area under the plasma drug concentration-time curve (AUC0-48 h) after 48 h of ginseng powder ingestion is maximum, indicating that in-vivo bioavailability of the ginseng powder is the highest. The method of this application can effectively inhibit the aggregation of the ultra-finely pulverized 1000-mesh ginseng powder by adding the ?-cyclodextrin, thus significantly improving the total dissolution amount of ginsenoside.
    Type: Grant
    Filed: September 13, 2023
    Date of Patent: April 23, 2024
    Assignees: JIANGNAN UNIVERSITY, STANDARD FOODS (CHINA) CO., LTD, LE BONTA WELLNESS CO., LTD
    Inventors: Peng Zhou, Changshu Liu, Tao Yang, Chang Liu, Yaowei Liu, Zikuan Zhao, Jianguo Liu, Kexin Li
  • Publication number: 20240099972
    Abstract: The present disclosure relates to a method to improve the encapsulation efficiency and physicochemical stability of ginsenosides Rg3 and CK nano-emulsion, belonging to the field of functional emulsions. The method to improve the encapsulation efficiency and physicochemical stability of ginsenosides Rg3 and CK nano-emulsion, includes the following steps: (1) WPI, Tween 80 and water were mixed evenly according to the amount ratio of 0.5 g:0.5-0.7 g:50 mL to obtain the aqueous phase; (2) Mixing a saponin extract containing the minor ginsenosides Rg3 and CK with edible oil evenly to obtain the oil phase; (3) Mixing the aqueous phase with the oil phase, carrying out shearing dispersion to obtain coarse emulsion, and then allowing the coarse emulsion to be subjected to microfluidization homogenization to obtain an oil-in-water nano-emulsion containing the minor ginsenosides Rg3 and CK.
    Type: Application
    Filed: December 1, 2023
    Publication date: March 28, 2024
    Inventors: Peng ZHOU, Changshu Liu, Yaowei Liu, Tao Yang, Yan Zheng, Jianguo Liu, Kexin Li, Shuyan Lu
  • Publication number: 20240093443
    Abstract: Disclosed in the present disclosure is a double-deck multi-span bridge construction method. According to the double-deck bridge construction method of the present disclosure, construction is carried out by using a method of disassembling a support jig frame in a graded and span-separated mode, an upper chord jig frame and a lower chord jig frame can be used in a recycle manner, and construction costs are reduced. In addition, a construction period of building the support jig frame is shortened, and other construction operations can be synchronously carried out on a span in which the jig frame is disassembled, for example, fire retardant coating construction can be carried out on a mounted bridge deck after the jig frame is disassembled, and the construction period of a double-deck multi-span bridge is effectively shortened.
    Type: Application
    Filed: September 23, 2021
    Publication date: March 21, 2024
    Applicant: CHINA CONSTRUCTION SCIENCE AND INDUSTRY CORPORATION LTD.
    Inventors: Jinglei REN, Bing SUN, Yonggang GAO, Hongyu SHEN, Shaohui ZHU, Jianguo QI, Cui LIU, Ruihua YAN, Zhiqiang HE, Longfei LI, Sijie YANG, Huaidong ZHANG, Xu CHEN, Wei JIANG, Wenbo LI, Yingwu SUN, Yuhang ZHANG
  • Publication number: 20240085595
    Abstract: A Fresnel lens in a lens body, the lens body is provided with a light incident surface and a light exit surface opposite to each other along a first direction, and the light exit surfaces are adjacently arranged in a second direction perpendicular to the first direction. There are several protruding teeth, and the protruding teeth are formed by an effective surface and an ineffective surface, and the ineffective surface is inclined at an acute angle relative to the first direction. The invention makes the light passing through the lens body reach the effective surface as much as possible, thereby reducing stray light and enhancing light efficiency.
    Type: Application
    Filed: September 8, 2023
    Publication date: March 14, 2024
    Inventors: Zuping He, Xiaoyun Liu, Jun Yang, Sheng Zhang, Kai Xu, Jianguo Dong, Huangfeng Pan
  • Publication number: 20230383964
    Abstract: A radiation heat dissipation and radiation heat collection-based cold and hot central air conditioning system includes a compressor, a liquid storage device, an indoor unit and an outdoor unit connected in sequence, the outdoor unit includes a radiation heat collector; the radiation heat collector includes a protective plate, a heat absorption plate, and a plate core; the heat absorption plate is located between the plate core and the protective plate; the plate core comprises a heat exchange medium inlet end and a heat exchange medium outlet end; and the heat absorption plate is used for transferring absorbed heat to a heat exchange medium circulating in the plate core. The heat absorption plate collects heat, and then transfers the heat to the heat exchange medium flowing in the plate core; and the heat exchange medium carrying the heat is compressed by the compressor, and then enters the indoor unit for heat exchange.
    Type: Application
    Filed: September 14, 2021
    Publication date: November 30, 2023
    Inventors: Jianguo YANG, Chengjun ZHOU, Weibo XIE, Quanjiang WANG, Jianhui KANG, Jilong ZHANG, Hui ZHAO, Lixuan HAO, Tongqin MAO, Wenjie CAO, Haiying CHAO, Xianting ZENG, Junzeng LI
  • Publication number: 20230366594
    Abstract: A three-dimensionally distributed liquid atomization heat exchanger includes a housing, an air extraction device, a heat exchange device and a liquid atomization device. The air extraction device is used for forming negative pressure in the housing. The liquid atomization device comprises a liquid supply pipe, atomization discharge pipes and atomization heads. The atomization discharge pipes are connected to the liquid supply pipe. The atomization heads are arranged on the atomization discharge pipes. The atomization discharge pipes are three-dimensionally distributed in the housing. Control devices are arranged on the atomization heads to control the atomization heads to be opened or closed. The control devices are connected to a control center which can, according to a preset time, a preset percentage of the atomization heads which are open and a randomization function, select randomly the atomization heads to be opened or closed.
    Type: Application
    Filed: September 14, 2021
    Publication date: November 16, 2023
    Inventors: Jianguo YANG, Chengjun ZHOU, Weibo XIE, Quanjiang WANG, Jianhui KANG, Jilong ZHANG, Hui ZHAO, Lixuan HAO, Tongqin MAO, Wenjie CAO, Haiying CHAO, Junzeng LI
  • Publication number: 20230241123
    Abstract: The present invention provides a pluripotent stem cell or a derivative thereof. A first nucleic acid molecule is introduced into a genome of the pluripotent stem cell or the derivative thereof; and a second nucleic acid molecule is introduced to a 3?UTR region of an immune response-related gene in the pluripotent stem cell or the derivative thereof. The first nucleic acid molecule encodes a small nucleic acid molecule that mediates RNA interference, and the small nucleic acid molecule can specifically bind to a transcript product of the second nucleic acid molecule to start an RNA interference program to degrade or silence mRNA of the immune response-related gene, thereby blocking the expression of the immune response-related gene, such that the cell has immunological compatibility, and thus can eliminate or reduce alloimmune rejection responses.
    Type: Application
    Filed: August 13, 2021
    Publication date: August 3, 2023
    Inventors: Linli Wang, Yuehua Chen, Jian Mo, Jianguo Yang
  • Publication number: 20230221044
    Abstract: A single-stage carbon dioxide multi-split cooling and heating multifunctional central air conditioner, comprising a single-stage carbon dioxide circulation system using carbon dioxide as a circulation working medium; the single-stage carbon dioxide circulation system comprises an outdoor unit and a plurality of end heat exchangers provided in parallel; and the carbon dioxide medium performs cooling and/or heating in a circulating manner in a carbon dioxide compressor, an outdoor heat exchanger, a liquid storage tank and the end heat exchangers which are in communication with one another.
    Type: Application
    Filed: September 14, 2021
    Publication date: July 13, 2023
    Inventors: Jianguo YANG, Chengjun ZHOU, Weibo XIE, Quanjiang WANG, Jianhui KANG, Jilong ZHANG, Hui ZHAO, Lixuan HAO, Tongqin MAO, Wenjie CAO, Haiying CHAO, Jiujiang LI, Xianting ZENG, Shiheng YANG
  • Publication number: 20230197152
    Abstract: Provided are a memory cell structure, a memory array structure, and a voltage biasing method. The memory cell structure includes: a substrate layer, a well layer and a transistor. The substrate layer is configured to support the memory cell structure; the well layer is embedded in the substrate layer, an upper surface of the well layer is flush with an upper surface of the substrate layer, and a transistor is arranged on the well layer. In the present disclosure, a deep well bias is performed on the memory cell structure, so that the well voltage of the memory cell may be individually biased to a specific voltage, and in combination with the redesigned memory cell array structure, the applied programming voltage mostly falls on the memory cell structure.
    Type: Application
    Filed: April 14, 2020
    Publication date: June 22, 2023
    Inventors: Hangbing LV, Jianguo YANG, Xiaoxin XU, Ming LIU
  • Publication number: 20230175009
    Abstract: Provided is an immunologically compatible and reversible universal pluripotent stem cell or a derivative thereof. An inducible gene expression system and the expression sequence of at least one immunologically compatible molecule are introduced into the genome of the pluripotent stem cell or the derivative thereof. The immunologically compatible molecule is used to regulate the expression of immune response-related genes in the pluripotent stem cell or the derivative thereof. The expression of the immunologically compatible molecule is regulated by the inducible gene expression system. The described method can increase the immunological compatibility between a transplant and a recipient, and can simultaneously reversibly restore the antigen-presenting abilities of transplant cells.
    Type: Application
    Filed: August 13, 2021
    Publication date: June 8, 2023
    Inventors: Linli WANG, Yuehua CHEN, Jianguo YANG, Jian MO
  • Publication number: 20220316779
    Abstract: A carbon dioxide refrigerating system and a refrigerating method thereof. A carbon dioxide refrigerating system, comprising a compressor (10), a condenser (11), a liquid storage device (12), and an evaporator (13) connected in sequence; a suction assembly (15) is arranged between the compressor (10) and the condenser (11), the suction assembly (1%) being in communication with the liquid storage device (12) and in communication with a gas-liquid separator (14), the gas-liquid separator (14) being arranged between the condenser (11) and the liquid storage device (12), and the carbon dioxide gas in the liquid storage device (12) or the gas-liquid separator (14) being capable of being sucked back into the pipeline between the compressor (10) and the condenser (11) by means of the suction assembly (15).
    Type: Application
    Filed: April 16, 2020
    Publication date: October 6, 2022
    Inventors: Jianguo YANG, Chengjun ZHOU, Jianhui KANG, Weibo XIE, Shiheng YANG, Chuangzi SHEN, Xiaobing SHENG, Wenjie CAO
  • Publication number: 20220252351
    Abstract: Disclosed is a flash closed heat exchanger, comprising a closed housing. A negative pressure fan is provided on the closed housing. A negative pressure environment is formed inside the closed housing by means of the negative pressure fan. A water atomization device is provided inside the closed housing. The water atomization device sprays atomized water into the inside of the closed housing, so that the atomized water evaporates into steam in the negative pressure environment.
    Type: Application
    Filed: April 16, 2020
    Publication date: August 11, 2022
    Inventors: Jianguo YANG, Chengjun ZHOU, Jianhui KANG, Weibo XIE, Wenjie CAO, Tongqin MAO, Hui ZHAO, Lixuan HAO
  • Publication number: 20220119822
    Abstract: An expression method, a vector and a vector composition are provided. In particular, a method for exogenously expressing a complex biological system in host cells, as well as a vector and a vector composition for the method are provided.
    Type: Application
    Filed: May 11, 2018
    Publication date: April 21, 2022
    Applicant: Peking University
    Inventors: Jianguo Yang, Xiaqing Xie, Nan Xiang, Zhexian Tian, Ray Dixon, Yiping Wang
  • Publication number: 20210324328
    Abstract: Provided herein are methods of culturing a mammalian cell and various methods that utilize these culturing methods. Also provided are multi-well cell culture plates, e.g., for use in perfusion culturing methods.
    Type: Application
    Filed: June 25, 2021
    Publication date: October 21, 2021
    Applicant: Genzyme Corporation
    Inventors: Agata Villiger-Oberbek, Jianguo Yang, Yang Yang, Gabrielle Lorenzo
  • Publication number: 20210230607
    Abstract: An expression method, a vector and a vector composition are provided. In particular, a method for exogenously expressing a complex biological system in host cells, as well as a vector and a vector composition for the method are provided.
    Type: Application
    Filed: May 11, 2018
    Publication date: July 29, 2021
    Applicant: Peking University
    Inventors: Jianguo Yang, Xiaqing Xie, Nan Xiang, Zhexian Tian, Ray Dixon, Yiping Wang
  • Patent number: 11060058
    Abstract: Provided herein are methods of culturing a mammalian cell and various methods that utilize these culturing methods. Also provided are multi-well cell culture plates, e.g., for use in perfusion culturing methods.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: July 13, 2021
    Assignee: Genzyme Corporation
    Inventors: Agata Villiger-Oberbek, Jianguo Yang, Yang Yang, Gabrielle Lorenzo
  • Publication number: 20200255798
    Abstract: Provided herein are methods of perfusion culturing an adherent mammalian cell using a shake flask and a plurality of microcarriers, and various methods that utilize these culturing methods.
    Type: Application
    Filed: March 2, 2020
    Publication date: August 13, 2020
    Applicant: Genzyme Corporation
    Inventors: Jianguo Yang, Yang Yang, Jennifer Tengtrakool, Weichang Zhou
  • Publication number: 20200080063
    Abstract: Provided herein are methods of culturing a mammalian cell and various methods that utilize these culturing methods.
    Type: Application
    Filed: August 28, 2019
    Publication date: March 12, 2020
    Applicant: Genzyme Corporation
    Inventors: Jianguo Yang, Yang Yang
  • Patent number: 10577583
    Abstract: Provided herein are methods of perfusion culturing an adherent mammalian cell using a shake flask and a plurality of microcarriers, and various methods that utilize these culturing methods.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: March 3, 2020
    Assignee: Genzyme Corporation
    Inventors: Jianguo Yang, Yang Yang, Jennifer Tengtrakool, Weichang Zhou
  • Publication number: 20190338257
    Abstract: Provided are an electron transport chain module from a eukaryotic organelle and an application thereof in biological nitrogen fixation. The electron transport chain (ETC) module is composed of the NifJ protein from Klebsiella oxytoca and a ferredoxin from plant chloroplasts or leucoplasts; plant-type ferredoxin-NADPH reductase (FNR) and the FdxH or FdxB protein from Anabaena; or an FNR and a Ferredoxin protein from plant organelles.
    Type: Application
    Filed: December 22, 2017
    Publication date: November 7, 2019
    Applicant: PEKING UNIVERSITY
    Inventors: Jianguo YANG, Mingxuan YANG, Ray DIXON, Yiping WANG, Xiaqing XIE