Patents by Inventor Jianguo Yin
Jianguo Yin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12116342Abstract: The present application relates to a method (I) for preparing a brivaracetam intermediate, comprising the steps of dissolving the compound represented by B-P and 1S,2S-diphenylethylenediamine in a solvent for resolution, crystallizing, filtering, and recrystallizing to obtain the compound represented by B-Q, which is then converted to the brivaracetam intermediate represented by B-R. This method can effectively resolve the compound represented by B-P. The present application also provides a method for preparing brivaracetam using the compound represented by B-R. The method can separate the effective components only through simple steps such as extraction, washing, drying, and concentration without requiring use of chiral chromatography column to separate isomers in the preparation process, and thus the separation process is simple, greatly reducing the production cost of brivaracetam.Type: GrantFiled: December 12, 2019Date of Patent: October 15, 2024Assignees: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD, SHANGHAI SYNCORES TECHNOLOGIES INC. LTD.Inventors: Haisheng Fan, Yipeng Zhan, Kai Yin, Xiang Ji, Fenghao Liu, Kaiqiang Shi, Xiaowen Guo, Luning Huang, Anping Tao, Jianguo An, Hong Gu
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Publication number: 20240310176Abstract: Example methods and apparatus for predicting a travelable lane are described. One example method includes obtaining forward lane line information backward lane line information of a host vehicle. A first lane model is constructed based on the forward lane line information of the host vehicle. A second lane model is constructed based on the backward lane line information of the host vehicle. A first travelable lane is predicted based on the first lane model and the second lane model.Type: ApplicationFiled: May 24, 2024Publication date: September 19, 2024Inventors: Xiaomeng YIN, Yi WANG, Jianguo WANG, Mo CHEN
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Publication number: 20210347758Abstract: Crystalline niraparib freebase is provided. Also provided are pharmaceutical compositions comprising crystalline niraparib freebase, and methods and uses pertaining to the same.Type: ApplicationFiled: October 3, 2019Publication date: November 11, 2021Inventors: Alistair James Stewart, Yi Wang, George Wu, Jianguo Yin
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Publication number: 20210347760Abstract: Novel salts of niraparib are provided. Also provided are pharmaceutical compositions comprising those salts, as well as methods and uses pertaining to the same.Type: ApplicationFiled: October 3, 2019Publication date: November 11, 2021Inventors: Alistair James Stewart, Yi Wang, George Wu, Jianguo Yin
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Patent number: 10992115Abstract: A landscape advertising light, box type miniaturized substation, belonging to the field of substations. The landscape advertising light box type miniaturized substation includes a box body; the box body is internally provided with a ring main unit, a transformer and an integrated low-voltage cabinet; the integrated low-voltage cabinet includes an incoming switch, a capacitor switch, a capacitor and an outgoing switch which are electrically connected in sequence; an output end of the ring main unit is electrically connected with an input end of the transformer, and an output end of the transformer is electrically connected with an input end of the incoming switch; a display screen is disposed outside the box body.Type: GrantFiled: November 11, 2019Date of Patent: April 27, 2021Assignee: Jiangsu Huafu Electric Power Technology Co., Ltd.Inventor: Jianguo Yin
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Publication number: 20210091543Abstract: A landscape advertising light box type miniaturized substation, belonging to the field of substations. The landscape advertising light box type miniaturized substation includes a box body; the box body is internally provided with a ring main unit, a transformer and an integrated low-voltage cabinet; the integrated low-voltage cabinet includes an incoming switch, a capacitor switch, a capacitor and an outgoing switch which are electrically connected in sequence; an output end of the ring main unit is electrically connected with an input end of the transformer, and an output end of the transformer is electrically connected with an input end of the incoming switch; a display screen is disposed outside the box body.Type: ApplicationFiled: November 11, 2019Publication date: March 25, 2021Inventor: Jianguo Yin
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Patent number: 10690262Abstract: A water hammer-proof air valve that has a valve body and a bonnet, that are fixedly connected, a valve opening is provided on the valve body, and a high-speed intake and exhaust device is provided in an inner cavity of the valve body. A bonnet opening is provided on the bonnet, an output end of the high-speed intake and exhaust device penetrates the bonnet opening and is communicated with a high-speed exhaust throttling device for limiting an exhaust amount of gas of the high-speed intake and exhaust device, an output end of the high-speed exhaust throttling device is communicated with an outside air, and a trace exhaust device for discharging the gas separated out from the pipeline to the outside through the high-speed exhaust throttling device after the high-speed intake and exhaust device closes the valve is further provided in the high-speed intake and exhaust device.Type: GrantFiled: May 30, 2016Date of Patent: June 23, 2020Assignee: ZHUZHOU SOUTHERN VALVE CO. LTD.Inventors: Jing Huang, Xinchun Gui, Jinpeng Tang, Jianguo Yin, Qiuhong Xu, Aihua Xie, Aihua Tang
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Patent number: 10464937Abstract: The present invention relates to processes for the preparation of N-protected (2S,5R)-6-hydroxy-7-oxo-N-piperidin-4-yl-1,6-diazabicyclo[3.2.1]octane-2-carboxamide intermediates. Such compounds have application in the preparation of beta-lactamase inhibitors such as 7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamides and esters, in particular, the beta lactamase inhibitor, (2S,5R)-7-oxo-N-piperidin-4-yl-6-(sulfoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide. The present invention also encompasses intermediates useful in the disclosed processes and methods for their preparation.Type: GrantFiled: September 14, 2017Date of Patent: November 5, 2019Assignee: Merck Sharp & Dohme Corp.Inventors: Jianguo Yin, Zhijian Liu, Nobuyoshi Yasuda, Mark Weisel
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Patent number: 10457690Abstract: The present invention is directed to processes for preparing Substituted Tetracyclic Heterocycle Compounds of formula (I): (I) which may be useful as HCV NS5A inhibitors. The present invention is also directed to compounds that may be useful as synthetic intermediates and catalysts in the processes of the invention.Type: GrantFiled: June 3, 2016Date of Patent: October 29, 2019Assignee: Merck Sharp & Dohme Corp.Inventors: Jingjun Yin, Tetsuji Itoh, Jianguo Yin, Bangping Xiang, Kevin R. Campos, Alexei Kalinin, Zhuqing Liu, Melodie Deniz Christensen, Kevin M. Belyk, Richard J. Varsolona, Andrew Brunskill
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Publication number: 20190233421Abstract: The present invention relates to processes for the preparation of N-protected (2S,5R)-6-hydroxy-7-oxo-N-piperidin-4-yl-1,6-diazabicyclo[3.2.1]octane-2-carboxamide intermediates. Such compounds have application in the preparation of beta-lactamase inhibitors such as 7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamides and esters, in particular, the beta lactamase inhibitor, (2S,5R)-7-oxo-N-piperidin-4-yl-6-(sulfoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide. The present invention also encompasses intermediates useful in the disclosed processes and methods for their preparation.Type: ApplicationFiled: September 14, 2017Publication date: August 1, 2019Applicant: Merck Sharp & Dohme Corp.Inventors: Jianguo Yin, Zhijian Liu, Nobuyoshi Yasuda, Mark Weisel
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Patent number: 10107405Abstract: The invention discloses a tilting disc check valve, which includes a left valve body (1), a right valve body (2), a large valve plate (3), a small valve plate (4) and a diaphragm control group (5), wherein the left valve body (1) and the right valve body (2) are butted into a whole through oblique openings; the oblique openings are inclined in a manner that upper parts are inclined towards the right valve body (2); the diaphragm control group (5) is arranged on the left valve body (1); the large valve plate (3) is arranged along the oblique openings; the large valve plate (3) is positioned in a valve cavity formed by the left valve body (1) and the right valve body (2); the large valve plate (3) is suspended on shaft holes of the left valve body (3) through valve shafts (6); the small valve plate (4) is connected with the diaphragm control group (5); and the small valve plate (4) is mounted at a slow closing valve port of the large valve plate (3) through a small valve plate pin shaft (7).Type: GrantFiled: July 4, 2014Date of Patent: October 23, 2018Assignee: ZHUZHOU SOUTHERN VALVE CO., LTD.Inventors: Jing Huang, Jianqun Luo, Xinchun Gui, Aihua Tang, Jianguo Yin, Zhen Dong
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Patent number: 10106541Abstract: The invention encompasses a novel process for making piperidinone carboxamide indane and azainane derivatives, which are CGRP receptor antagonists useful for the treatment of migraine.Type: GrantFiled: December 19, 2017Date of Patent: October 23, 2018Assignee: Merck Sharp & Dohme Corp.Inventors: Frank Chen, Carmela Molinaro, W. Peter Wuelfing, Nobuyoshi Yasuda, Jianguo Yin, Yong-Li Zhong, Joseph Lynch, Teresa Andreani
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Publication number: 20180179223Abstract: The present invention is directed to processes for preparing Substituted Tetracyclic Heterocycle Compounds of formula (I): (I) which may be useful as HCV NS5A inhibitors. The present invention is also directed to compounds that may be useful as synthetic intermediates and catalysts in the processes of the invention.Type: ApplicationFiled: June 3, 2016Publication date: June 28, 2018Applicant: MERCK SHARP & DOHME CORP.Inventors: Jingjun Yin, Tetsuji Itoh, Jianguo Yin, Bangping Xiang, Kevin R. Campos, Alexei Kalinin, Zhuqing Liu, Melodie Deniz Christensen, Kevin M. Belyk, Richard J. Varsolona, Andrew Brunskill
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Publication number: 20180149287Abstract: A water hammer-proof air valve that has a valve body and a bonnet, that are fixedly connected, a valve opening is provided on the valve body, and a high-speed intake and exhaust device is provided in an inner cavity of the valve body. A bonnet opening is provided on the bonnet, an output end of the high-speed intake and exhaust device penetrates the bonnet opening and is communicated with a high-speed exhaust throttling device for limiting an exhaust amount of gas of the high-speed intake and exhaust device, an output end of the high-speed exhaust throttling device is communicated with an outside air, and a trace exhaust device for discharging the gas separated out from the pipeline to the outside through the high-speed exhaust throttling device after the high-speed intake and exhaust device closes the valve is further provided in the high-speed intake and exhaust device.Type: ApplicationFiled: May 30, 2016Publication date: May 31, 2018Inventors: Jing HUANG, Xinchun GUI, Jinpeng TANG, Jianguo YIN, Qiuhong XU, Aihua XIE, Aihua TANG
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Publication number: 20180127417Abstract: The invention encompasses a novel process for making piperidinone carboxamide indane and azainane derivatives, which are CGRP receptor antagonists useful for the treatment of migraine.Type: ApplicationFiled: December 19, 2017Publication date: May 10, 2018Applicant: Merck Sharp & Dohme Corp.Inventors: Frank Chen, Carmela Molinaro, W. Peter Wuelfing, Nobuyoshi Yasuda, Jianguo Yin, Yong-Li Zhong, Joseph Lynch
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Patent number: 9850246Abstract: The invention encompasses a novel process for making piperidinone carboxamide indane and azainane derivatives, which are CGRP receptor antagonists useful for the treatment of migraine.Type: GrantFiled: September 15, 2015Date of Patent: December 26, 2017Assignee: MERCK SHARP & DOHME CORP.Inventors: Frank Chen, Carmela Molinaro, W. Peter Wuelfing, Nobuyoshi Yasuda, Jianguo Yin, Yong-Li Zhong, Joseph Lynch, Teresa Andreani
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Patent number: 9487523Abstract: The invention encompasses a novel process for making piperidinone carboxamide indane and azainane derivatives, which are CGRP receptor antagonists useful for the treatment of migraine, utilizing a highly effective spiroacid synthesis.Type: GrantFiled: March 13, 2013Date of Patent: November 8, 2016Assignee: Merck Sharp & Dohme Corp.Inventors: Kevin M. Belyk, Edward Cleator, Shen-Chun Kuo, Peter Emmanuel Maligres, Bangping Xiang, Nobuyoshi Yasuda, Jianguo Yin
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Publication number: 20160130273Abstract: The invention encompasses a novel process for making piperidinone carboxamide indane and azainane derivatives, which are CGRP receptor antagonists useful for the treatment of migraine.Type: ApplicationFiled: September 15, 2015Publication date: May 12, 2016Applicant: MERCK SHARP & DOHME CORP.Inventors: Frank Chen, Carmela Molinaro, W. Peter Wuelfing, Nobuyoshi Yasuda, Jianguo Yin, Yong-Li Zhong, Joseph Lynch, Teresa Andreani
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Publication number: 20160053904Abstract: The invention discloses a tilting disc check valve, which includes a left valve body (1), a right valve body (2), a large valve plate (3), a small valve plate (4) and a diaphragm control group (5), wherein the left valve body (1) and the right valve body (2) are butted into a whole through oblique openings; the oblique openings are inclined in a manner that upper parts are inclined towards the right valve body (2); the diaphragm control group (5) is arranged on the left valve body (1); the large valve plate (3) is arranged along the oblique openings; the large valve plate (3) is positioned in a valve cavity formed by the left valve body (1) and the right valve body (2); the large valve plate (3) is suspended on shaft holes of the left valve body (3) through valve shafts (6); the small valve plate (4) is connected with the diaphragm control group (5); and the small valve plate (4) is mounted at a slow closing valve port of the large valve plate (3) through a small valve plate pin shaft (7).Type: ApplicationFiled: July 4, 2014Publication date: February 25, 2016Inventors: Jing HUANG, Jianqun LUO, Xinchun GUI, Aihua TANG, Jianguo YIN, Zhen DONG
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Patent number: 9174989Abstract: The disclosure encompasses a novel process for making piperidinone carboxamide indane and azainane derivatives, having less steps and improved yields as compared to previous synthetic methods for making these compounds, which are CGRP receptor antagonists, useful for the treatment of migraine. Conditions for an amide bond formation between an acid and amine include for example reacting the compounds of Formulae B (after salt break) and C with an amide coupling reagent and optionally an additive and an acid and/or a base in a non-reactive solvent.Type: GrantFiled: March 12, 2013Date of Patent: November 3, 2015Assignee: Merck Sharp & Dohme Corp.Inventors: Frank Chen, Carmela Molinaro, W. Peter Wuelfing, Nobuyoshi Yasuda, Jianguo Yin, Yong-Li Zhong, Joseph Lynch, Teresa Andreani