Patents by Inventor Jianhua Chao

Jianhua Chao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thiadiazoles AS CXC- and CC- chemokine receptor ligands
    Publication number: 20060223864
    Abstract: Disclosed are novel compounds of the formula: and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and ischemia reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of formula IA.
    Type: Application
    Filed: December 16, 2004
    Publication date: October 5, 2006
    Inventors: Purakkattle Biju, Arthur Taveras, J. Merritt, John Baldwin, Younong Yu, Junying Zheng, Jianhua Chao, Cynthia Aki, Jay Fine, Daniel Lundell, Tony Priestley, Angelo Reggiani
  • Isothiazole dioxides as CXC- and CC-chemokine receptor ligands
    Publication number: 20060025453
    Abstract: Disclosed are novel compounds of the formula: and the pharmaceutically acceptable salts and solvates thereof. D and E are different groups wherein one is N and the other is CR50. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of formula IA.
    Type: Application
    Filed: December 20, 2004
    Publication date: February 2, 2006
    Inventors: Arthur Taveras, J. Merritt, John Baldwin, Junying Zheng, Purakkattle Biju, Younong Yu, Jianhua Chao, Jay Fine, Daniel Lundell, Tony Priestley, Angelo Reggiani, Gaifa Lai, Minglang Wu
  • CXCR1 and CXCR2 chemokine antagonists
    Publication number: 20060014794
    Abstract: The present invention is directed to a compound having the general structure of formula (1): useful for the treatment, prevention or amelioration of a CXCR1 or CXCR2 chemokine-mediated disease.
    Type: Application
    Filed: May 11, 2005
    Publication date: January 19, 2006
    Inventors: Jianhua Chao, Arthur Taveras, Cynthia Aki, Daniel Lundell, Jay Fine, Tony Priestley, Angelo Reggiani
  • 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
    Patent number: 6878709
    Abstract: Disclosed are compounds of the formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
    Type: Grant
    Filed: January 2, 2003
    Date of Patent: April 12, 2005
    Assignees: Schering Corporation, Pharmacopeia Drug Discovery, Inc.
    Inventors: Arthur G. Taveras, Michael Dwyer, Jianping Chao, John J. Baldwin, J. Robert Merritt, Ge Li, Jianhua Chao, Younong Yu
  • Thiadiazoledioxides and thiadiazoleoxides as CXC- and CC- chemokine receptor ligands
    Publication number: 20040186142
    Abstract: Disclosed are novel compounds of the formula: 1
    Type: Application
    Filed: October 7, 2003
    Publication date: September 23, 2004
    Applicant: Schering Corporation Pharmacopeia, Inc.
    Inventors: Arthur G. Taveras, Jianhua Chao, Purakkattle J. Biju, Younong Yu, Jay S. Fine, William Hipkin, Cynthia J. Aki, J. Robert Merritt, Ge Li, John J. Baldwin, Gaifa Lai, Minglang Wu, Evan A. Hecker
  • 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
    Publication number: 20040147559
    Abstract: There are disclosed compounds of the formula 1
    Type: Application
    Filed: July 30, 2003
    Publication date: July 29, 2004
    Applicant: Schering Corporation and Pharmacopeia, Inc.
    Inventors: Arthur G. Taveras, Cynthia J. Aki, Richard W. Bond, Jianping Chao, Michael Dwyer, Johan A. Ferreira, Jianhua Chao, Younong Yu, John J. Baldwin, Bernd Kaiser, Ge Li, J. Robert Merritt, Purakkattle J. Biju, Kingsley H. Nelson, Laura L. Rokosz, James P. Jakway, Gaifa Lai, Minglang Wu, Evan A. Hecker, Daniel Lundell, Jay S. Fine
  • 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
    Publication number: 20040106794
    Abstract: There are disclosed compounds of the formula 1
    Type: Application
    Filed: September 11, 2002
    Publication date: June 3, 2004
    Applicant: Schering Corporation
    Inventors: Arthur G. Taveras, Cynthia J. Aki, Richard W. Bond, Jianping Chao, Michael Dwyer, Johan A. Ferreira, Jianhua Chao, Younong Yu, John J. Baldwin, Bernd Kaiser, Ge Li, J. Robert Merritt, Purakkattle J. Biju, Kingsley H. Nelson, Laura L. Rokosz
  • 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
    Publication number: 20040097547
    Abstract: There are disclosed compounds of the formula 1
    Type: Application
    Filed: July 30, 2002
    Publication date: May 20, 2004
    Inventors: Arthur G. Taveras, Cynthia J. Aki, Richard W. Bond, Jianping Chao, Michael Dwyer, Johan A. Ferreira, Jianhua Chao, Younong Yu, John J. Baldwin, Bernd Kaiser, Ge Li, J. Robert Merritt, Kingsley H. Nelson, Laura L. Rokosz
  • 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
    Publication number: 20040063709
    Abstract: Disclosed compounds of the formula (I) 1
    Type: Application
    Filed: January 2, 2003
    Publication date: April 1, 2004
    Applicant: SCHERING CORPORATION
    Inventors: Arthur G. Taveras, Michael Dwyer, Jianping Chao, John J. Baldwin, J. Robert Merritt, Ge Li, Jianhua Chao, Younong Yu
  • Treatment of chemokine mediated diseases
    Publication number: 20040053953
    Abstract: Methods of treating chemokine-mediated diseases are disclosed.
    Type: Application
    Filed: March 17, 2003
    Publication date: March 18, 2004
    Applicant: Schering Corporation
    Inventors: Arthur G. Taveras, Motasim Billah, Daniel Lundell, William Kreutner, James Jakway, Jay S. Fine, Loretta A. Bober, Jianhua Chao, Purakkattle J. Biju, Younong Yu