Abstract: Provided herein, inter alia, are PD-L1(+) natural killer cells that express soluble IL-15, PD-L1(+) natural killer cells that express soluble IL-15 and truncated EGFR, and methods of treating cancer using the PD-L1(+) natural killer cells. In an aspect is provided a method of treating cancer in a patient in need thereof comprising administering to the patient an effective amount of PD-L1(+) natural killer cells that express soluble IL-15.

Abstract: An approach for calibrating prestack seismic inversion is provided. This method includes selecting various features from inverted elastic properties to generate reservoir properties; fully connected neural network models are used to learn the mapping between the features and ground truth data at well locations; and the prediction is applied to generate one or more final models for the reservoir characterization of the whole survey region.

Abstract: CAR cells targeting FLT3 antigens in combination with a secreted anti-PD-1 and anti-PD-L1 antibodies or anti-PD-1-anti-PD-L1 bispecific antibodies are described as a new method of cancer treatment. It is proposed that these combination therapies are safe and effective in patients and can be used to treat human tumors and cancer.

Abstract: An approach for calibrating prestack seismic inversion is provided. This method includes selecting various features from inverted elastic properties to generate reservoir properties; fully connected neural network models are used to learn the mapping between the features and ground truth data at well locations; and the prediction is applied to generate one or more final models for the reservoir characterization of the whole survey region.

Abstract: Provided herein, inter alia, are methods for expanding a population of human group 2 innate lymphoid cells (ILC2), and methods of treating cancer in a subject including administering to the subject the population of expanded human ILC2. Further provided are genetically engineered human ILC2s including chimeric antigen receptors, and methods of treating cancer in a subject including administering to the subject the genetically engineered human ILC2.

Abstract: Methods, apparatuses, and mediums related to a full-wavefield angle gather generation for high-contrast inter-thin bed modeling for reservoir characterizations of a survey region are provided. A method may include a well logging tool having one or more sonic generators and one or more well log data recording sensors in a wellbore. Sound waves may be generated using the one or more sonic generators in order to generate reflections in the survey region. Well log data, based on the reflections, may be received using well log data recording sensors, and the well log data may be transmitted to at least one memory. A method may perform, using a computer system, a full-wavefield angle gather generation. A method may generate, by a computer system, the high-contrast inter thin-bed models based on the full-wavefield angle gather.

Abstract: Provided herein, inter alia, are genetically-modified natural killer (NK) cells capable of expressing platelet-derived growth factor (PDGF) and/or platelet-derived growth factor receptor (PDGFR); pharmaceutical compositions comprising the genetically-modified natural killer (NK) cells; methods of treating cancer with the genetically-modified natural killer (NK) cells; and methods of expanding a population of NK cells using PDGF.

Abstract: Described herein are compositions comprising human natural killer (NK) cells engineered to reduce or eliminate Cbl-b and with or without a chimeric antigen receptor (CAR), methods of making such compositions, and methods of using such compositions (e.g., killing cancer cells, treating a subject having cancer or viral infection).

Abstract: This disclosure features novel cell lines and related methods for producing human natural killer (NK) cells, compositions of the NK cells produced by these methods, and uses thereof.

Abstract: Provided herein are, inter alia, compositions comprising ex vivo expanded ILC1 cells, methods of preparing the compositions, and methods useful for treating cancer and leukemia.

Abstract: A battery pack comprising housing and battery arranged on said housing, wherein heat-exchanger-flow-channel is provided for regulating the temperature of the battery, and said heat-exchanger-flow-channel comprises heat-exchanger-inlet, heat-exchanger-outlet, and at least one flow section connecting said heat-exchanger-inlet and said heat-exchanger-outlet; said heat-exchanger-inlet and said heat-exchanger-outlet are located higher than said flow section; said flow section is connected to said heat-exchanger-inlet through feeding chamber, and when the horizontal cross-sectional area of said feeding chamber at a position connected to said heat-exchanger-inlet is defined as A and the cross-sectional area of said heat-exchanger-inlet is defined as B, 0.5A?B?1.

Abstract: A battery pack comprising: a housing and a battery provided in the housing, the housing provided with a heat exchange agent flow-path; the battery comprising a battery module provided with at least two battery cores arranged in parallel; the heat exchange agent flow-path comprising at least two branches, each branch being located at one side of each battery core; wherein the width direction of the branches is the same as the width direction of the battery cores, and which the width of the battery cores is defined is X and the width of the branches is defined as Y, 0.5X?Y<X.

Abstract: Described herein, inter alia, are methods of treating a coronavirus infection.

Abstract: A battery pack including: housing and battery provided in the housing; two or more heat exchange agent flow-paths for regulating temperature of the battery in the housing; the heat exchange agent flow-paths having heat-exchange-agent-inlet and heat-exchange-agent-outlet, the distance of the heat-exchange-agent-inlet from the center of the battery pack being greater than the distance of the heat-exchange-agent-outlet from the center of the battery pack; the heat exchange agent flow-paths further includes first-flow-section and second-flow-section; one end of the first-flow-section being in communication with the heat-exchange-agent-inlet; one end of the second-flow-section being in communication with the heat-exchange-agent-outlet; the other end of the first-flow-section being in communication with the other end of the second-flow-section; the distance between the first-flow-section and the center of the battery pack being greater than the distance between the second-flow-section and the center of the battery

Abstract: Disclosed in the present application is an electronic cigarette, including a cigarette stem and a cartridge, in which a battery and a PCB board are provided in the cigarette stem, an atomizer configured for a atomization of e-liquid is provided in the cartridge, the atomizer includes a ceramic atomizing core, a heating wire configured for heating the e-liquid and a temperature sensing element configured for a temperature detection of the heating wire, the heating wire and the temperature sensing element are provided on the ceramic atomizing core, the heating wire is electrically connected to the battery, the temperature sensing element is electrically connected to the PCB board.

Abstract: Nucleic acid molecules encoding an IL-15 domain and a chimeric antigen receptor (CAR) that targets cells expressing prostate stem cell antigen are provided as well as polypeptides encoded thereby. Vectors and host cells such as immune cells containing the nucleic acid molecules also are disclosed, as well as methods for their use.

Abstract: Disclosed herein are chimeric antigen receptors (CAR) that can specifically recognize tumor-associated antigens (TAA) on multiple myeloma (MM) cells. Also disclosed are immune effector cells, such as T cells or Natural Killer (NK) cells, that are engineered to express these CARs. Therefore, also disclosed are methods of providing an anti-tumor immunity in a subject with MM that involves adoptive transfer of the disclosed immune effector cells engineered to express the disclosed CARs.

Abstract: Chimeric antigen receptors (CAR) targeted to SARS-CoV-2 Spike protein and NK cells expressing such CAR are described. The CAR are targeted to SARS-CoV-2 Spike protein via an scFv or a variant human ACE2 protein. In some cases, the NK cells also express human IL-15 or a soluble fragment thereof.

Abstract: The present application relates to the technical field of thermodetector, and discloses a high stability Bluetooth temperature measuring probe, including a needle tube having a hollow mounting chamber, a handle configured to abut against a tail end of the needle tube, a first thermal sensor positioned in the mounting chamber of the needle tube close to the head end, an antenna mounted inside the needle tube and electrically connected to the first thermal sensor, and a locking assembly configured for connecting the handle to the needle tube. The locking assembly includes a locking member, a locking nut and a limiting nut, in which the limiting nut is connected to the antenna and is configured to limit the locking member; and an inner wall of the needle tube is defined with a locking slot.

Abstract: The disclosure provides oncolytic herpes virus comprising a heterologous gene encoding E-cadherin. The disclosure further provides pharmaceutical compositions that comprise such oncolytic herpes virus, and methods of treatment using such oncolytic herpes virus.