Patents by Inventor Jianing Wang
Jianing Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240144160Abstract: Systems and methods for reconciling location based on multiple computing device signals. For example, the computing system can obtain location datasets associated with freight carrier services from computing sources. The computing system can determine an expected signal pattern for a location associated with a freight transportation service. The computing system can determine, for each computing source, a confidence score. The confidence score can represent the probability that the respective location dataset is associated with a load being transported for a freight transportation service. The computing system can determine a primary location dataset based on the confidence scores. The computing system can perform actions based on the primary location dataset.Type: ApplicationFiled: October 28, 2022Publication date: May 2, 2024Inventors: Ajinkya Manoj Deshpande, Mudit Gupta, Siddharth Rane, Martin Alan Tromblee, Jianing Wang, Yu Wang, David Wee, Cheng Wei
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Patent number: 11763502Abstract: A deep-learning-based method for metal artifact reduction in CT images includes providing a dataset and a cGAN. The dataset includes CT image pairs, randomly partitioned into a training set, a validation set, and a testing set. Each Pre-CT and Post-CT image pairs is respectively acquired in a region before and after an implant is implanted. The Pre-CT and Post-CT images of each pair are artifact-free CT and artifact-affected CT images, respectively. The cGAN is conditioned on the Post-CT images, includes a generator and a discriminator that operably compete with each other, and is characterized with a training objective that is a sum of an adversarial loss and a reconstruction loss. The method also includes training the cGAN with the dataset; inputting the post-operatively acquired CT image to the trained cGAN; and generating an artifact-corrected image by the trained cGAN, where metal artifacts are removed in the artifact-corrected image.Type: GrantFiled: August 6, 2019Date of Patent: September 19, 2023Assignee: VANDERBILT UNIVERSITYInventors: Benoit M. Dawant, Jianing Wang, Jack H. Noble, Robert F. Labadie
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Publication number: 20230099074Abstract: Antibody drug conjugates (ADCs) comprising an antibody conjugated to an anti-inflammatory therapeutic agent via a phosphate-based linker with tunable extracellular and intracellular stability are described.Type: ApplicationFiled: October 26, 2022Publication date: March 30, 2023Applicants: Merck Sharp & Dohme LLC, Ambrx, Inc.Inventors: Philip E. Brandish, Robert M. Garbaccio, Jeffrey Kern, Linda Liang, Sanjiv Shah, Dennis Zaller, Andrew Beck, Dennis Gately, Nick Knudsen, Anthony Manibusan, Jianing Wang, Ying Sun
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Publication number: 20220409734Abstract: The present disclosure provides antibody drug conjugates comprising STING modulators. Also provided are compositions comprising the antibody drug conjugates. The compounds and compositions are useful for stimulating an immune response in a subject in need thereof.Type: ApplicationFiled: May 8, 2020Publication date: December 29, 2022Inventors: Dylan Bradley ENGLAND, Steve P. LANGSTON, Hong Myung LEE, Liting MA, Zhan SHI, Stepan VYSKOCIL, Jianing WANG, He XU, Yutaka NISHIMOTO, Yumiko ISHII
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Patent number: 11510993Abstract: Antibody drug conjugates (ADCs) comprising an antibody conjugated to an anti-inflammatory therapeutic agent via a phosphate-based linker with tunable extracellular and intracellular stability are described.Type: GrantFiled: September 30, 2016Date of Patent: November 29, 2022Assignees: Merck Sharp & Dohme LLC, Ambrx, Inc.Inventors: Philip E. Brandish, Robert M. Garbaccio, Jeffrey Kern, Linda Liang, Sanjiv Shah, Dennis Zaller, Andrew Beck, Dennis Gately, Nick Knudsen, Anthony Manibusan, Jianing Wang, Ying Sun
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Patent number: 11419548Abstract: A flexible photonic skin is provided, including a functional layer, an adhesive layer used for fixing the functional layer and made of hypoallergenic polyvinyl ethyl ether, and a packaging layer made of a polyurethane semi-transparent film and adhered to the adhesive layer, which are arranged successively from the top down, wherein the functional layer consists of two electrodes located on two sides and used for acquiring electrocardiographic signals of a human body, and a polymer-based photonic integrated chip located between the two electrodes and used for acquiring body temperature, pulse, blood pressure and blood glucose signals of the human body; and, the polymer-based photonic integrated chip processes and outputs the acquired electrocardiographic signals of the human body as well as the body temperature, pulse, blood pressure and blood glucose signals of the human body.Type: GrantFiled: March 25, 2020Date of Patent: August 23, 2022Assignee: TIANGONG UNIVERSITYInventors: Hongqiang Li, Rui Xie, Xiaoqing Wei, Jianing Wang
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Publication number: 20220226488Abstract: Disclosed herein are Trastuzumab-linked TLR-agonist derivative analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The Trastuzumab-linked TLR-agonist derivative analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid Trastuzumab-linked TLR-agonist derivative analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such Trastuzumab-linked TLR-agonist derivative analogs. Typically, the modified Trastuzumab-linked TLR-agonist derivative analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group.Type: ApplicationFiled: February 12, 2020Publication date: July 21, 2022Inventors: Sung-Ju MOON, Brian LEON, Mingchao KANG, Nickolas KNUDSEN, Jianing WANG, Sukumar SAKAMURI, Feng TIAN
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Publication number: 20220181628Abstract: A lithium-sulfur battery includes a substrate; a sulfur cathode disposed on the substrate; a coating layer disposed on the cathode; a first interlayer disposed on the coating layer; a solid-state electrolyte disposed on the first interlayer; a second interlayer disposed on the electrolyte; and a lithium anode disposed on the second interlayer, such that the coating layer is further disposed within pores of the cathode.Type: ApplicationFiled: April 14, 2020Publication date: June 9, 2022Inventors: Michael Edward Badding, Jun Jin, Zhen Song, Jianing Wang, Zhaoyin Wen, Tongping Xiu
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Publication number: 20220084264Abstract: A deep-learning-based method for metal artifact reduction in CT images includes providing a dataset and a cGAN. The dataset includes CT image pairs, randomly partitioned into a training set, a validation set, and a testing set. Each Pre-CT and Post-CT image pairs is respectively acquired in a region before and after an implant is implanted. The Pre-CT and Post-CT images of each pair are artifact-free CT and artifact-affected CT images, respectively. The cGAN is conditioned on the Post-CT images, includes a generator and a discriminator that operably compete with each other, and is characterized with a training objective that is a sum of an adversarial loss and a reconstruction loss. The method also includes training the cGAN with the dataset; inputting the post-operatively acquired CT image to the trained cGAN; and generating an artifact-corrected image by the trained cGAN, where metal artifacts are removed in the artifact-corrected image.Type: ApplicationFiled: August 6, 2019Publication date: March 17, 2022Inventors: Benoit M. DAWANT, Jianing WANG, Jack H. NOBLE, Robert F. LABADIE
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Patent number: 11082386Abstract: The present invention relates to 2?-Fluoro-6?-methylene carbocyclic nucleosides, pharmaceutical compositions containing these nucleosides and their use in the treatment or prophylaxis of a number of viral infections and secondary disease states and conditions thereof, especially including Hepatitis B virus (HBV) and secondary disease states and conditions thereof (cirrhosis and liver cancer), Heptatitis C virus (HCV), Herpes Simplex virus I and II (HSV-1 and HSV-2), cytomegalovirus (CMV), Varicella-Zoster Virus (VZV) and Epstein Barr virus (EBV) and secondary cancers which occur thereof (lymphoma, nasopharyngeal cancer, including drug resistant (especially including lamivudine and/or adefovir resistant) and other mutant forms of these viruses, especially HBV.Type: GrantFiled: November 26, 2019Date of Patent: August 3, 2021Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.Inventors: Chung K. Chu, Jianing Wang
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Publication number: 20210218478Abstract: The disclosure provides a subspace-based blind identification algorithm of an ocean underwater acoustic channel for multi-channel fir filter, which adopts a technical solution that a channel impulse response coefficient is calculated by quadratic minimization. The disclosure has beneficial effects that estimation precision can be met when using a proper number of samples, and especially when a few noise vectors are used for estimating channel parameters, so that calculation amount is greatly reduced.Type: ApplicationFiled: August 26, 2020Publication date: July 15, 2021Applicant: Institute of Oceanology, Chinese Academy of SciencesInventors: Xiangguang ZHANG, Jianing WANG, Fan WANG
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Patent number: 11050492Abstract: The disclosure provides a subspace-based blind identification algorithm of an ocean underwater acoustic channel for multi-channel fir filter, which adopts a technical solution that a channel impulse response coefficient is calculated by quadratic minimization. The disclosure has beneficial effects that estimation precision can be met when using a proper number of samples, and especially when a few noise vectors are used for estimating channel parameters, so that calculation amount is greatly reduced.Type: GrantFiled: August 26, 2020Date of Patent: June 29, 2021Assignee: Institute of Oceanology, Chinese Academy of SciencesInventors: Xiangguang Zhang, Jianing Wang, Fan Wang
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Publication number: 20210015940Abstract: The invention relates to prostate specific membrane antigen humanized antibodies (anti-PSMA) and anti-PSMA antibody drug conjugates. The invention also relates to methods and compositions for using anti-PSMA antibody drug conjugates in inhibiting, preventing or treating PSMA related diseases or cancers.Type: ApplicationFiled: March 29, 2019Publication date: January 21, 2021Applicant: Ambrx, Inc.Inventors: Shivarupam Bhowmik, Jianing Wang, Jinming Xia, William Brady, Feng Tian
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Publication number: 20200373996Abstract: The present invention discloses a system for real-time transmission of large-capacity of a deep-sea subsurface mooring based on a Beidou satellite. Data transmission is implemented by a mechanism of single module multi-card switching operation and dynamic subcontracting transmission. A receiving module is connected to a fixed card and is responsible for receiving state information on whether the transmission is successful. A subsurface mooring end antenna and a land-based antenna adopt a network analyzer to perform secondary matching on parameters such as frequency offset and impedance of the assembled antenna, and effectively intercept original data. In addition, arithmetic coding and dictionary coding are adopted for data compression. While an acquisition board terminal processes original valid data, the valid data is compressed to a maximum of one third of the original data, which can be extended into a parallel mode of multiple single-mode multi-card modules.Type: ApplicationFiled: May 20, 2020Publication date: November 26, 2020Inventors: Jianing Wang, Xiangguang Zhang, Fan Wang
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Publication number: 20200359963Abstract: A flexible photonic skin is provided, including a functional layer, an adhesive layer used for fixing the functional layer and made of hypoallergenic polyvinyl ethyl ether, and a packaging layer made of a polyurethane semi-transparent film and adhered to the adhesive layer, which are arranged successively from the top down, wherein the functional layer consists of two electrodes located on two sides and used for acquiring electrocardiographic signals of a human body, and a polymer-based photonic integrated chip located between the two electrodes and used for acquiring body temperature, pulse, blood pressure and blood glucose signals of the human body; and, the polymer-based photonic integrated chip processes and outputs the acquired electrocardiographic signals of the human body as well as the body temperature, pulse, blood pressure and blood glucose signals of the human body.Type: ApplicationFiled: March 25, 2020Publication date: November 19, 2020Inventors: Hongqiang LI, Rui XIE, Xiaoqing WEI, Jianing WANG
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Patent number: 10717119Abstract: The present invention relates to a potential difference-based diversion electrode arrangement and field intensity compensation method, comprising the following steps: the arrangement positions of paired diversion electrodes are determined according to the difference of potential around a position of field intensity to be compensated and the direction of an electric field line, and the paired diversion electrodes are inserted; and the field intensity enhancement rate of the position of field intensity to be compensated and the compensated field intensity value are calculated according to the difference of potential and arrangement positions of the paired diversion electrodes.Type: GrantFiled: March 30, 2016Date of Patent: July 21, 2020Assignee: Shenyang Institute of Applied Ecology, Chinese Academy of SciencesInventors: Shuhai Guo, Bo Wu, Fengmei Li, Jianing Wang
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Publication number: 20200220830Abstract: The present invention relates to 2?-Fluoro-b?-methylene carbocyclic nucleosides, pharmaceutical compositions containing these nucleosides and their use in the treatment or prophylaxis of a number of viral infections and secondary disease states and conditions thereof, especially including Hepatitis B virus (HBV) and secondary disease states and conditions thereof (cirrhosis and liver cancer), Heptatitis C virus (HCV), Herpes Simplex virus I and II (HSV-1 and HSV-2), cytomegalovirus (CMV), Varicella-Zoster Virus (VZV) and Epstein Barr virus (EBV) and secondary cancers which occur thereof (lymphoma, nasopharyngeal cancer, including drug resistant (especially including lamivudine and/or adefovir resistant) and other mutant forms of these viruses, especially HBV.Type: ApplicationFiled: November 26, 2019Publication date: July 9, 2020Applicant: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.Inventors: Chung K. Chu, Jianing Wang
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Publication number: 20200164085Abstract: Antibody drug conjugates (ADCs) comprising an antibody conjugated to an anti-inflammatory therapeutic agent via a phosphate-based linker with tunable extracellular and intracellular stability are described.Type: ApplicationFiled: September 30, 2016Publication date: May 28, 2020Inventors: Philip E. Brandish, Robert M Garbaccio, Jeffrey Kern, Linda Liang, Sanjiv Shah, Dennis Zaller, Andrew Beck, Dennis Gately, Nick Knudsen, Anthony Manibusan, Jianing Wang, Ying Sun
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Patent number: 10662487Abstract: A Pseudomonas sp. ECO-1 strain was preserved at the China General Microbiological Culture Collection Center (CGMCC) on Mar. 31, 2017, with the preservation number of CGMCC No. 13960. The Pseudomonas sp. ECO-1 strain was separated from POPs (Persistent Organic Pollutants) polluted soil for the first time. The bifunctional enzyme preparation capable of efficiently degrading polychlorinated biphenyl and atrazine was prepared by utilizing the strain for the first time; especially, the bifunctional enzyme preparation has remarkable degradation activity on the polychlorinated biphenyl which is difficult to degrade under an aerobic condition, which is completely different from functions of existing known Pseudomonas sp. and enzyme preparations thereof.Type: GrantFiled: June 12, 2018Date of Patent: May 26, 2020Assignee: Ecology Institute, Shandong Academy of SciencesInventors: Lei Ji, Qiang Zhang, Guanhong Chen, Jianing Wang, Xiaowen Fu, Fanyong Song, Tianyuan Li
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Patent number: 10550190Abstract: Phosphate-based linkers with tunable stability for intracellular delivery of drug conjugates are described. The phosphate-based linkers comprise a monophosphate, diphosphate, triphosphate, or tetraphosphate group (phosphate group) and a linker arm comprising a tuning element and optionally a spacer. A payload is covalently linked to the phosphate group at the distal end of the linker arm and the functional group at the proximal end of the linker arm is covalently linked to a cell-specific targeting ligand such as an antibody. These phosphate-based linkers have a differentiated and tunable stability in blood vs. an intracellular environment (e.g. lysosomal compartment).Type: GrantFiled: March 30, 2015Date of Patent: February 4, 2020Assignees: Merck Sharp & Dohme Corp., Ambrx, Inc.Inventors: Robert M. Garbaccio, Jeffrey Kern, Philip E. Brandish, Sanjiv Shah, Linda Liang, Ying Sun, Jianing Wang, Nick Knudsen, Andrew Beck, Anthony Manibusan, Dennis Gately