Patents by Inventor Jianing Yang
Jianing Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210079337Abstract: Provided are automated cell culture systems and related in vitro cell culture methods, including for a co-culture of different cell populations having different cell culture conditions. For example, the system may comprise a bioreactor having a plurality of cell culture compartments, the bioreactor having a fluid port fluidly connected to the plurality of cell culture compartments. A pump fluidly connected to the fluid port can provide a cell culture medium to the plurality of culture compartments. A sensor is operably connected to at least one of the plurality of cell culture compartments for measuring at least one cell culture parameter. In this manner, a controller electronically connected the pump and sensor, is configured to automatically adjust a pump flow rate and/or a cell culture gas content to provide a desired steady-state cell culture parameter for facilitating cells interactions and collection of products representative of said interactions.Type: ApplicationFiled: March 29, 2019Publication date: March 18, 2021Inventors: Frederic ZENHAUSERN, Matthew W. BARRETT, Carla BROOKS, Peng CHEN, Brett M. DUANE, Marie Oceane PARENT, Stanley D. SMITH, Baiju THOMAS, Jianing YANG
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Publication number: 20180257077Abstract: Instruments, devices and methods of analysis are provided which fully integrate a significant number of process steps in a continuous operation. Accurate positioning and full contact between components is also provided by the relative movement the designs allow. An effect interface between a low cost disposable cartridge or device and the instrument to process it is also detailed.Type: ApplicationFiled: January 10, 2018Publication date: September 13, 2018Inventors: Frederic ZENHAUSERN, Alan NORDQUIST, Ralf LENIGK, Cedric HURTH, Jianing YANG, Xiaojia CHEN, John LEE-EDGHILL, Nina MORAN, Andrew HOPWOOD, Pieris KOUMI
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Publication number: 20170087553Abstract: A method and device structure are provided which enable an archive sample to be collected and detached relative to a device within which a series of processes, such as PCR are being provided. A chamber structure and method of use are provided in which a controlled and precise volume is obtained by control of the relative resistance to flow through various channels.Type: ApplicationFiled: September 2, 2016Publication date: March 30, 2017Inventors: Frederic ZENHAUSERN, Alan NORDQUIST, Ralf LENIGK, Cedric HURTH, Jianing YANG, Xiaojia CHEN, Matthew ESTES, John LEE-EDGHILL, Nina MORAN, Andrew HOPWOOD, Pieris KOUMI, Zhi CAI
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Publication number: 20160187293Abstract: An electrophoresis device where the end of the electrophoresis channel has a part that extends vertically. The electrophoresis channel includes a first access port at one end of the channel and a second port at the other end of the channel, which are in the same horizontal plane. In this way, there is a less than 0.1% hydrostatic pressure differential between two ports and the performance of the device is improved.Type: ApplicationFiled: June 11, 2012Publication date: June 30, 2016Applicants: The Arizona Board of Regents acting for and on behalf of University of Arizona, BioAccelInventors: Frederic ZENHAUSERN, Alan NORDQUIST, Ralf LENIGK, Cedric HURTH, Jianing YANG, Xiaojia CHEN, Matthew ESTES, John LEE-EDGHILL, Nina MORAN, Andrew HOPWOOD, Pieris KOUMI
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Publication number: 20150238958Abstract: The present invention provides a microfluidic device for preparing or extracting a biological sample from a solid material and methods for using the same. The microfluidic device of the invention automates the biological sample extraction from a solid material, thereby significantly reducing the possibility of contamination, human error and a potential variability of the sample that is obtained by different technicians.Type: ApplicationFiled: September 13, 2013Publication date: August 27, 2015Inventors: Frederic Zenhausern, Matthew Estes, Jianing Yang
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Publication number: 20140186841Abstract: A method, system, and apparatus for analysis of a biological sample includes receiving the sample, wherein the sample includes deoxyribonucleic acid (DNA), lysing the sample to obtain access to the DNA included in the sample, purifying the DNA in the sample to isolate the DNA from other components in the sample, amplifying the DNA, separating fragments of the amplified DNA, detecting the separated fragments using laser induced fluorescence, based on the detecting, generating a profile of the DNA in the received sample, comparing the generated profile with profiles of DNA stored in a database, and upon determining that the generated profile matches one of the stored profiles, identifying the source from which the stored profile was obtained, wherein the receiving, lysing, purifying, amplifying, and detecting are performed on corresponding portions of a microfluidic device, and wherein transporting the sample and the DNA to the portions of the microfluidic device and enabling the lysing, purifying, amplifying,Type: ApplicationFiled: September 23, 2013Publication date: July 3, 2014Inventors: Frederic ZENHAUSERN, Ralf LENIGK, Jianing YANG, Zhi CAI, Alan NORDQUIST, Stanley D. SMITH, David MAGGIANO, Glen MCCARTY, Mrinalini PRASAD, Karem LINAN, Baiju THOMAS, Edward OLAYA, Cedric HURTH, Darryl COX, Mark RICHARD
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Publication number: 20140178938Abstract: A method and device structure are provided which enable an archive sample to be collected and detached relative to a device within which a series of processes, such as PCR are being provided. A chamber structure and method of use are provided in which a controlled and precise volume is obtained by control of the relative resistance to flow through various channels.Type: ApplicationFiled: July 8, 2013Publication date: June 26, 2014Inventors: Frederic ZENHAUSERN, Alan NORDQUIST, Ralf LENIGK, Cedric HURTH, Jianing YANG, Xiaojia CHEN, Matthew ESTES, John LEE-EDGHILL, Nina MORAN, Andrew HOPWOOD, Pieris KOUMI, Zhi CAI
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Publication number: 20140116121Abstract: Instruments, devices and methods of analysis are provided which fully integrate a significant number of process steps in a continuous operation. Accurate positioning and full contact between components is also provided by the relative movement the designs allow. An effect interface between a low cost disposable cartridge or device and the instrument to process it is also detailed.Type: ApplicationFiled: January 3, 2014Publication date: May 1, 2014Applicant: BioAccelInventors: Frederic ZENHAUSERN, Alan NORDQUIST, Ralf LENIGK, Cedric HURTH, Jianing YANG, Xiaojia CHEN, John LEE-EDGHILL, Nina MORAN, Andrew HOPWOOD, Pieris KOUMI
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Patent number: 8685747Abstract: Methods, apparatuses, and systems for collecting samples using hybrid porous materials that include an organic material and an inorganic material. A method for sample collection includes contacting a hybrid porous material and a biological sample to the porous material. The hybrid porous material includes an inorganic material and an organic material. The method includes placing the porous material with the attached sample in a liquid medium, wherein the sample is separated from the porous material in the liquid medium to form a separated sample, and collecting the separated sample in the medium.Type: GrantFiled: August 14, 2009Date of Patent: April 1, 2014Assignee: Arizona Board of Regents, A body corporate of the State of Arizona Acting for and on Behalf of Arizona State UniversityInventors: Frederic Zenhausern, Ralf Lenigk, James Kinder, Jianing Yang
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Patent number: 8640555Abstract: Instruments, devices and methods of analysis are provided which fully integrate a significant number of process steps in a continuous operation. Accurate positioning and full contact between components is also provided by the relative movement the designs allow. An effect interface between a low cost disposable cartridge or device and the instrument to process it is also detailed.Type: GrantFiled: February 9, 2010Date of Patent: February 4, 2014Assignee: BioAccelInventors: Frederic Zenhausern, Alan Nordquist, Ralf Lenigk, Cedric Hurth, Jianing Yang, Xiaojia Chen, John Lee-Edghill, Nina Moran, Andrew Hopwood, Pieris Koumi
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Publication number: 20130323737Abstract: A method and system for analysing a sample are provided, wherein one or more process steps and/or sample processors are provided separately from the instrument, for instance a sample receiving step and sample preparation step and sample extraction step and sample retention step and/or purification step and washing step and elution step, and one or more process steps and/or sample processors provided by the instrument as an integrated set, the one or more process steps and/or sample processors provided by the instrument including a sample receiving step and amplification step and denaturing step and investigation step and detection step and results analysis step and results output step. Other combinations of the split in location of the steps are possible. The optimisation of the split allows the accurate processing by a cartridge based instrument of the sample, whilst fully interfacing with a variety of sample collection and/or preparation approaches.Type: ApplicationFiled: August 10, 2011Publication date: December 5, 2013Applicant: BIOACCELInventors: Frederic Zenhausern, Alan Nordquist, Ralf Lenigk, Cedric Hurth, Jianing Yang, Xiaojia Chen, Matthew Estes, John Lee-Edghill, Nina Moran, Andrew Hopwood, Pieris Koumi
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Publication number: 20130130365Abstract: A method of analysis, instrument for analysis and device for use in such an instrument are provided, which perform a number of processes need to reach a useful result in the context of a wide variety of samples. The sequence of those processes being optimised. A device, instrument using the device and method of use are also provided which offer reliable performance of a heating based process, with minimal condensation and/or sample loss issues.Type: ApplicationFiled: October 11, 2012Publication date: May 23, 2013Inventors: Frederic ZENHAUSERN, Alan NORDQUIST, Ralf LENIGK, Cedric HURTH, Jianing YANG, Xiaojia CHEN, Matthew ESTES, John LEE-EDGHILL, Nina MORAN, Andrew HOPWOOD, Pieris KOUMI
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Publication number: 20120082985Abstract: A method, system, and apparatus for analysis of a biological sample includes receiving the sample, wherein the sample includes deoxyribonucleic acid (DNA), lysing the sample to obtain access to the DNA included in the sample, purifying the DNA in the sample to isolate the DNA from other components in the sample, amplifying the DNA, separating fragments of the amplified DNA, detecting the separated fragments using laser induced fluorescence, based on the detecting, generating a profile of the DNA in the received sample, comparing the generated profile with profiles of DNA stored in a database, and upon determining that the generated profile matches one of the stored profiles, identifying the source from which the stored profile was obtained, wherein the receiving, lysing, purifying, amplifying, and detecting are performed on corresponding portions of a microfluidic device, and wherein transporting the sample and the DNA to the portions of the microfluidic device and enabling the lysing, purifying, amplifying,Type: ApplicationFiled: August 11, 2008Publication date: April 5, 2012Inventors: Frederic Zenhausern, Ralf Lenigk, Jianing Yang, Zhi Cai, Alan Nordquist, Stanley D. Smith, David Maggiano, Mrinalini Prasad, Karem Linan, Edward Olaya, Baiju Thomas, Cedric Hurth, Darryl Cox, Mark Richard, Glen Mccarty
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Publication number: 20120034601Abstract: Methods, apparatuses, and systems for collecting samples using hybrid porous materials that include an organic material and an inorganic material. A method for sample collection includes contacting a hybrid porous material and a biological sample to the porous material. The hybrid porous material includes an inorganic material and an organic material. The method includes placing the porous material with the attached sample in a liquid medium, wherein the sample is separated from the porous material in the liquid medium to form a separated sample, and collecting the separated sample in the medium.Type: ApplicationFiled: August 14, 2009Publication date: February 9, 2012Inventors: Frederic Zenhausern, Ralf Lenigk, James Kinder, Jianing Yang
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Publication number: 20110100101Abstract: Instruments, devices and methods of analysis are provided which fully integrate a significant number of process steps in a continuous operation. Accurate positioning and full contact between components is also provided by the relative movement the designs allow. An effect interface between a low cost disposable cartridge or device and the instrument to process it is also detailed.Type: ApplicationFiled: February 9, 2010Publication date: May 5, 2011Inventors: Frederic Zenhausern, Alan Nordquist, Ralf Lenigk, Cedric Hurth, Jianing Yang, Xiaojia Chen, John Lee-Edghill, Nina Moran, Andrew Hopwood, Pieris Koumi
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Publication number: 20100267092Abstract: A method and device structure are provided which enable an archive sample to be collected and detached relative to a device within which a series of processes, such as PCR are being provided. A chamber structure and method of use are provided in which a controlled and precise volume is obtained by control of the relative resistance to flow through various channels.Type: ApplicationFiled: February 9, 2010Publication date: October 21, 2010Inventors: Frederic ZENHAUSERN, Alan Nordquist, Ralf Lenigk, Cedric Hurth, Jianing Yang, Xiaojia Chen, Matthew Estes, John Lee-Edghill, Nina Moran, Andrew Hopwood, Pieris Koumi, Zhi Cai
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Publication number: 20100221726Abstract: A method of analysis, instrument for analysis and device for use in such an instrument are provided, which perform a number of processes need to reach a useful result in the context of a wide variety of samples. The sequence of those processes being optimised. A device, instrument using the device and method of use are also provided which offer reliable performance of a heating based process, with minimal condensation and/or sample loss issues.Type: ApplicationFiled: February 9, 2010Publication date: September 2, 2010Inventors: Frederic Zenhausern, Alan Nordquist, Ralf Lenigk, Cedric Hurth, Jianing Yang, Xiaojia Chen, Matthew Estes, John Lee-Edghill, Nina Moran, Andrew Hopwood, Pieris Koumi
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Publication number: 20100213063Abstract: Analysis methods and apparatus are provided for inspecting a channel, such as a capillary electrophoresis channel, in a device. Configuration and alignment systems are provided, together with optical systems and temperature control.Type: ApplicationFiled: February 9, 2010Publication date: August 26, 2010Inventors: Frederic ZENHAUSERN, Alan Nordquist, Ralf Lenigk, Cedric Hurth, Jianing Yang