Abstract: The present disclosure provides a modified deodorant urea-formaldehyde (UF) resin and use thereof, as well as a particleboard and a preparation method thereof, and relates to the technical field of wood-based panels. Raw materials for preparing the modified deodorant UF resin provided by the present disclosure include: melamine-modified UF resin (MUF), aluminum ammonium sulfate dodecahydrate, wax, and water. Raw materials for preparing the MUF include: urea, formaldehyde, and melamine. When the modified deodorant UF resin provided by the present disclosure is used to prepare wood-based panels, the aluminum ammonium sulfate dodecahydrate losses 12 crystal water during hot pressing to form a metastable structure NH4Al(SO4)2, in which NH4+ can react with the formaldehyde to reduce formaldehyde emission, and NH4+ and A13+ can absorb hydroxyl groups of organic substances to form hydrogen bonds to reduce odor of the wood-based panels.