Abstract: This disclosure relates to anti-CitH3 (citrullinated histone H3) antibodies, antigen-binding fragments, and the uses thereof.

Abstract: A knowledge distillation system and method trains neural networks utilizing a non-conventional relay buffer and augmented data tuples. In at least one embodiment, the knowledge distillation system and method pretrain a teacher model that implements a contextual bandit algorithm. A lightweight student model determines online contextual bandit data tuples as to context x, arm/action a, and reward/payoff r. The data tuples are stored in a replay buffer. The teacher model randomly samples data tuples from the replay buffer and augments the sampled data tuples. Augmented data tuples are stored in the replay buffer. The student model batch processes augmented data tuples to update parameters of contextual bandit data tuples.

Abstract: Cosmeceutical compositions for and methods of improving the appearance of skin and promoting hair growth are provided. Said compositions comprise at least one ROS-scavenging polymer gel, at least MG53, or a combination thereof. A novel boronate ester-based copolymer forms an aqueous hydrogel exhibiting lower viscosity at cooler temperatures and higher viscosity at higher temperatures is provided.

Abstract: Compositions for and methods of treating irritable bowel disease are provided. The compositions and methods employ MG53, which can be in the form of recombinant human MG53. The MG53 can be administered in a form to avoid or bypass gastric digestion or degradation. The composition can include a live MG53-expressing microbe, such as a probiotic composition that expresses MG53 in the gastrointestinal tract of a subject. An enteric release composition comprising MG53 is also provided.

Abstract: Compositions for and methods of improving tissue function are provided. Said compositions comprise MG53 or express MG53. Said compositions can be used for improving the function of non-diseased and uninjured tissue in subjects.

Abstract: Compositions for and methods of treating liver injury are provided. Said compositions comprise MG53 or express MG53. Said compositions can be used for treating chronic or acute injured liver tissue and can be administered systemically, locally, or both.

Abstract: Compositions for and methods of preventing, reversing or treating viral infection-induced organ failure provided. The compositions are also suitable for treating and/or preventing COVID-19 and influenza. The compositions and methods employ MG53, which can be in the form of recombinant human MG53. The MG53 may also be administered as a composition that expresses and releases MG53 after in vivo administration of said composition to a subject.

Abstract: Disclosed herein are nucleic acid sequences that encode pro-apoptotic polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of proliferative disorders and bacterial infections using the nucleic acids and proteins of the invention.

Abstract: Disclosed herein are compositions and methods for measuring the level of MG53 found in a biological fluid as a biomarker for a disease or disorder, e.g., tissue damage, exercise capacity or a muscle-related disease or disorder. In addition, the invention relates to targeting the native MG53 found in the blood as a therapeutic approach.

Abstract: Disclosed herein are compositions and methods for repairing cell membranes. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the composition facilitates the repair of cell membranes. Moreover, the invention relates to the treatment and/or prevention of pathological conditions associated with cell membrane damage.

Abstract: Described herein are example systems and operations for enhancing targeted delivery of online content using action rate lift and/or A/B testing. These examples provide solutions to problems in targeted delivery of online content, such as the problem of not being able to identify audience and/or situational targets mostly or only influenced by the content item or campaign of concern. For example, described herein are solutions that can estimate AR lift associated with a content item, and then distribute the content item or similar content items accordingly. An AR lift model can be used and such a model can use machine learning, A/B testing, and/or statistical analysis.

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. In particular, the present invention provides nucleic acid molecules that include optimization features that enhance the expression and/or recovery and/or activity of encoded polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract: Disclosed herein are compositions and methods for the treatment and/or protection of airway cells and/or tissue from damage due to injury to the lungs or complications of underlying respiratory, cardiovascular or infectious diseases, or any combination thereof.

Abstract: Disclosed herein are compositions and methods for the treatment and/or prevention of pathological conditions associated with ischemia/reperfusion injury and/or hypoxic injury of myocardial cell or tissue.

Abstract: Disclosed herein are compositions and methods for treatment of muscle dysfunction, including diabetes. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the composition facilitates the treatment of skeletal muscle disorders. Moreover, the invention relates to the treatment and/or prevention of pathological conditions associated with altered intracellular Ca2+ regulation and disrupted membrane structure that occurs when the expression levels of MG29 are reduced.

Abstract: Disclosed herein are compositions and methods for treatment of muscle dysfunction (including sarcopenia) and other diseases involving skeletal muscle, including age-related muscle dysfunction. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the composition facilitates the treatment of skeletal muscle disorder, including those related to thr normal aging process. Moreover, the invention relates to the treatment and/or prevention of pathological conditions associated with altered intracellular Ca2+ regulation and disrupted membrane structure that occurs when the expression levels of MG29 are reduced.

Abstract: Disclosed herein are compositions and methods for measuring the level of MG53 found in a biological fluid as a biomarker for a disease or disorder, e.g., tissue damage, exercise capacity or a muscle-related disease or disorder. In addition, the invention relates to targeting the native MG53 found in the blood as a therapeutic approach.

Abstract: In an embodiment, a data processing method comprises obtaining a plurality of first transaction data items for a proposed online credit card purchase transaction that has been recommended for review; obtaining a plurality of second transaction data items for a set of similar past online credit card purchase transactions, wherein each member of the set has one or more transaction feature values that are similar to the transaction data items of the proposed online credit card purchase transaction, and a decision value specifying whether the member was accepted or rejected by a reviewer; obtaining a stored data model of features, feature values, transaction acceptance decisions and rejection decisions of the reviewer based at least in part on the set, determining, based on applying the first transaction data items to the stored data model and a subsequent query to the database among more recent transactions that were not included during model construction, a likelihood value of a particular decision of whether t

Abstract: Disclosed herein are compositions and methods for the treatment and/or prevention of pathological conditions associated with ischemia/reperfusion injury and/or hypoxic injury of myocardial cell or tissue.

Abstract: Modern technologies of signal processing and real-time feedback adaptive control are applied to a fraud screen model to enable the fraud screen model to adapt to changes in shopping behavior to effectively maintain the model's performance on a review rate score curve continuously. Multiple techniques disclosed herein integrate control technologies with modeling technology to control the review rate score curve in real time.