Patents by Inventor Jian Jie Ma

Jian Jie Ma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhancers of CFTR chloride channel function
    Patent number: 6770739
    Abstract: Phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR) by cyclic AMP-dependent protein kinase (PKA) is essential for opening the CFTR chloride channel. A short segment containing many negatively charged amino acids (817-838, NEG2) within the regulatory (R) domain of CFTR is a critical regulator of the chloride channel activity. Deletion of NEG2 from CFTR completely eliminates the PKA dependence of the chloride channel. Exogenous NEG2 peptide interacts with the CFTR molecule and exhibits stimulatory effects on CFTR function. Our data suggest that NEG2 interacts with other cytosolic domains of CFTR to control the opening transitions of the chloride channel.
    Type: Grant
    Filed: February 24, 2000
    Date of Patent: August 3, 2004
    Assignee: Case Western Reserve University
    Inventors: Lynn Adams, Pamela B. Davis, Jian Jie Ma
  • Enhancers of CFTR chloride channel function
    Publication number: 20040121957
    Abstract: Phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR) by cyclic AMP-dependent protein kinase (PKA) is essential for opening the CFTR chloride channel. A short segment containing many negatively charged amino acids (817-838, NEG2) within the regulatory (R) domain of CFTR is a critical regulator of the chloride channel activity. Deletion of NEG2 from CFTR completely eliminates the PKA dependence of the chloride channel. Exogenous NEG2 peptide interacts with the CFTR molecule and exhibits stimulatory effects on CFTR function. Our data suggest that NEG2 interacts with other cytosolic domains of CFTR to control the opening transitions of the chloride channel.
    Type: Application
    Filed: December 23, 2003
    Publication date: June 24, 2004
    Applicant: Case Western Reserve University
    Inventors: Lynn Adams, Pamela B. Davis, Jian Jie Ma