Abstract: Provided in the present invention are a compound as shown in formula I, various crystal forms thereof, a hydrate, a solvate or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition. The compound of the present invention can effectively treat Alzheimer's disease or Down's syndrome, especially cognitive function impairment caused by Alzheimer's disease or Down's syndrome. Also disclosed in the present invention is use of a ubiquitin specific protease USP25 encoded and expressed by chromosome 21 for preventing, treating or ameliorating Alzheimer's disease or Down's syndrome.

Abstract: The present invention provides a compound as represented by formula I, or a pharmaceutically acceptable salt or ester, a prodrug, an optical isomer, a stereoisomer, or a solvate thereof. The compound provided by the present invention can be used for preparing drugs for preventing or treating hypertension, or hypertension-related diseases, or pulmonary hypertension, or pulmonary hypertension-related diseases. The compound provided by the present invention has a different mechanism from existing drugs for treating hypertension and pulmonary hypertension, thereby laying a new material foundation for the development of drugs for treating hypertension and pulmonary hypertension.

Abstract: A battery safety valve and temperature detection circuit, includes a battery, a temperature sensor, and a reference resistor that are connected in series to form a loop, and a safety valve sensor arranged outside a battery safety valve. The temperature sensor is arranged on the battery, voltage acquisition wires are connected to a positive electrode and a negative electrode of the battery respectively, a partial voltage acquisition wire is connected to a wire connected between the temperature sensor and a reference resistor, the voltage acquisition wires and the partial voltage acquisition wire are connected to corresponding voltage acquisition ports of an acquisition chip respectively. The safety valve sensor is connected in parallel to the reference resistor; and when the safety valve is open, a liquid in the battery is in contact with a bottom of the safety valve sensor, and the safety valve sensor is short-circuited.

Abstract: Provided in the present invention are a compound as shown in formula I, various crystal forms thereof, a hydrate, a solvate or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition. The compound of the present invention can effectively treat Alzheimer's disease or Down's syndrome, especially cognitive function impairment caused by Alzheimer's disease or Down's syndrome. Also disclosed in the present invention is use of a ubiquitin specific protease USP25 encoded and expressed by chromosome 21 for preventing, treating or ameliorating Alzheimer's disease or Down's syndrome.

Abstract: The present invention provides a compound as represented by formula I, or a pharmaceutically acceptable salt or ester, a prodrug, an optical isomer, a stereoisomer, or a solvate thereof. The compound provided by the present invention can be used for preparing drugs for preventing or treating hypertension, or hypertension-related diseases, or pulmonary hypertension, or pulmonary hypertension-related diseases. The compound provided by the present invention has a different mechanism from existing drugs for treating hypertension and pulmonary hypertension, thereby laying a new material foundation for the development of drugs for treating hypertension and pulmonary hypertension.

Abstract: A circuit breaker having a first micro switch, a second micro switch and a transmission mechanism. The transmission mechanism drives the first micro switch and the second micro switch, which are arranged in a circuit breaker shell. The first micro switch and the second micro switch are arranged on one side of the shell side by side, and a corresponding first transmission rod and a corresponding second transmission rod in the transmission mechanism respectively drive the first micro switch and the second micro switch. Since the circuit breaker is provided with no external device, the space occupied by the circuit breaker is reduced, thereby facilitating construction and installation. Since the two micro switches are built-in side by side, different signals can be simultaneously output.

Abstract: A circuit breaker having a first micro switch, a second micro switch and a transmission mechanism. The transmission mechanism drives the first micro switch and the second micro switch, which are arranged in a circuit breaker shell. The first micro switch and the second micro switch are arranged on one side of the shell side by side, and a corresponding first transmission rod and a corresponding second transmission rod in the transmission mechanism respectively drive the first micro switch and the second micro switch. Since the circuit breaker is provided with no external device, the space occupied by the circuit breaker is reduced, thereby facilitating construction and installation. Since the two micro switches are built-in side by side, different signals can be simultaneously output.