Abstract: Provided are a compound III serving as an LSD1 inhibitor and a crystal form thereof, as well as use of the compound and the crystal form thereof in preparation of a medicament for treating an LSD1 related disease.

Abstract: Disclosed are 6-carbamate substituted heteroaryl ring derivatives and a preparation method therefor. The present application particularly relates to a compound as shown in formula (II) and a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to a thiophene compound and an application thereof. The present invention specifically relates to a compound represented by formula (II) and a pharmaceutically acceptable salt thereof, wherein L1 is —C(?O)— or —C(?O)—NH—; R1 is R1a or aa; ring A is bb or cc; R1a is C1-3 alkyl substituted with 1, 2 or 3 Ra; and R3 is independently H, halogen or C1-3 alkoxy. The compound represented by formula (II) and the pharmaceutically acceptable salt thereof can better inhibit the activity of LSD1, further shows significant inhibitory activity against NCI-H1417 cell proliferation, and has good pharmacokinetic properties (including good oral bioavailability, oral exposure, half-life, and clearance rate, etc.).

Abstract: Substituted pyridazine phenol derivatives and a preparation method therefor, specifically relating to a compound as shown in formula (VI) and a pharmaceutically acceptable salt thereof, which can be used as an NLRP3 inhibitor.

Abstract: The present disclosure provides a direct type backlight module (1) and a display device. The direct type backlight module (1) includes: a back plate (10) including a body (110) and a side plate (120) protruding around an edge of the body (110), the body (110) and the side plate (120) are enclosed to form a receiving cavity (100), and a back surface of the body (110) is partially recessed towards the receiving cavity (100) to form a mounting groove (130); and a rear housing (20), covering the mounting groove (130), a back surface of the rear housing (20) is flush with an edge of the mounting groove (130) of the body (110). The direct type backlight module (1) overcomes the defect in the conventional display device that the rear housing protrudes from the back plate, causing uneven thickness of the display device.

Abstract: Disclosed are a class of pyrazole compounds and applications thereof in the preparation of a medicament for treating related diseases. Specifically, related are a compound represented by formula (II) and a pharmaceutically acceptable salt thereof.

Abstract: A cyclopropylamine compound as a lysine-specific demethylase 1 (LSD1) inhibitor. Particularly, the present invention relates to a compound represented by formula (I) and a pharmaceutically acceptable salt thereof. The present invention also provides an application of the same in preparing a drug for treating an LSD1-related disease.

Abstract: The disclosure relates to the technical field of veterinary biological products, and discloses an avian influenza and fowl adenovirus type 4 bi-combined genetic engineering subunit vaccine. An antigen in the vaccine is a fusion antigen; the fusion antigen has a) avian influenza virus HA protein; b) fowl adenovirus fiber2 protein; c) a specific linker peptide located between the avian influenza virus HA protein and the fowl adenovirus fiber2 protein; the amino acid sequence of the specific linker peptide is as shown in SEQ ID NO:2. This vaccine contains the fusion antigen which can induce poultries to produce a high-level specific antibody to protect poultries from avian influenza and fowl adenovirus infection. Meanwhile, the disclosure also discloses a method for preparing the vaccine.

Abstract: Disclosed are a class of pyrazole compounds and applications thereof in the preparation of a medicament for treating related diseases. Specifically, related are a compound represented by formula (II) and a pharmaceutically acceptable salt thereof.

Abstract: The disclosure relates to the technical field of veterinary biological products, and discloses an avian influenza and fowl adenovirus type 4 bi-combined genetic engineering subunit vaccine. An antigen in the vaccine is a fusion antigen; the fusion antigen has a) avian influenza virus HA protein; b) fowl adenovirus fiber2 protein; c) a specific linker peptide located between the avian influenza virus HA protein and the fowl adenovirus fiber2 protein; the amino acid sequence of the specific linker peptide is as shown in SEQ ID NO:2. This vaccine contains the fusion antigen which can induce poultries to produce a high-level specific antibody to protect poultries from avian influenza and fowl adenovirus infection. Meanwhile, the disclosure also discloses a method for preparing the vaccine.

Abstract: Provided are a compound III serving as an LSD1 inhibitor and a crystal form thereof, as well as use of the compound and the crystal form thereof in preparation of a medicament for treating an LSD1 related disease.

Abstract: A cyclopropylamine compound as a lysine-specific demethylase 1 (LSD1) inhibitor. Particularly, the present invention relates to a compound represented by formula (I) and a pharmaceutically acceptable salt thereof. The present invention also provides an application of the same in preparing a drug for treating an LSD1-related disease.

Abstract: The present disclosure provides a direct type backlight module (1) and a display device. The direct type backlight module (1) includes: a back plate (10) including a body (110) and a side plate (120) protruding around an edge of the body (110), the body (110) and the side plate (120) are enclosed to form a receiving cavity (100), and a back surface of the body (110) is partially recessed towards the receiving cavity (100) to form a mounting groove (130); and a rear housing (20), covering the mounting groove (130), a back surface of the rear housing (20) is flush with an edge of the mounting groove (130) of the body (110). The direct type backlight module (1) overcomes the defect in the conventional display device that the rear housing protrudes from the back plate, causing uneven thickness of the display device.

Abstract: Compositions and methods directed to ESAT-6 variants which serve as vaccines for the prevention and prophylactic treatment of TB.

Abstract: Compositions and methods directed to ESAT-6 variants which serve as vaccines for the prevention and prophylactic treatment of TB.

Abstract: A device for testing mechanical seal performance includes a main shaft (4), a working chamber (18) with two end covers (6, 13) respectively located at two ends thereof, and two groups of mechanical seals to be tested (7); wherein a shaft sleeve (5) and the main shaft (4) form a clearance fit and penetrate through the end covers (6, 13) at two ends of the working chamber (18) together; the shaft sleeve (5) extends outside U-shaped openings (23) which are arranged at two ends of the end covers (6, 13) and arranged on the same generatrix; driven pins (15) are arranged on the locations of the main shaft (4) corresponding to the U-shaped openings (23); the middle part of the shaft sleeve (5) is provided with two segments of threads having the same thread pitch and opposite rotating directions.

Abstract: A device for testing mechanical seal performance includes a main shaft (4), a working chamber (18) with two end covers (6, 13) respectively located at two ends thereof, and two groups of mechanical seals to be tested (7); wherein a shaft sleeve (5) and the main shaft (4) form a clearance fit and penetrate through the end covers (6, 13) at two ends of the working chamber (18) together; the shaft sleeve (5) extends outside U-shaped openings (23) which are arranged at two ends of the end covers (6, 13) and arranged on the same generatrix; driven pins (15) are arranged on the locations of the main shaft (4) corresponding to the U-shaped openings (23); the middle part of the shaft sleeve (5) is provided with two segments of threads having the same thread pitch and opposite rotating directions.