Abstract: Disclosed herein are gene therapy vectors used for efficiently transducing cells to express a human ?-globin gene. Specifically disclosed is an expression vector which comprises: an expression cassette for a ?-globin gene, which comprises exons and introns of human ?-globin gene, as well as cis-acting elements including one or more of WPRE, SV40 polyadenylation signal and/or SV40 ori. The disclosed expression vectors have significantly enhanced viral vector packaging efficiency in viral vector packaging cell lines, which leads to effective integration of lentiviral vectors and high expression level of ?-globin gene in target cells. Also disclosed are pharmaceutical compositions and therapeutic methods utilizing such expression vectors.

Abstract: A high anti-interference microsystem based on System In Package (SIP) for a power grid is provided. The high anti-interference microsystem comprises a ceramic cavity, a ceramic substrate, a magnetic cover plate, a digital signal processing circuit, an analog signal conditioning circuit and a shield, wherein the ceramic cavity supports the ceramic substrate, the magnetic cover plate is in sealed contact with the ceramic cavity, and the ceramic substrate is arranged in a cavity formed by the ceramic cavity and the magnetic cover plate; a sealed shell of the microsystem based on SIP is composed of the magnetic cover plate and the ceramic cavity; the digital signal processing circuit and the analog signal conditioning circuit are arranged on the ceramic substrate and respectively process received signals to be processed; the shield covers an outer side of the sealed shell and is used for shielding external magnetic field interference.

Abstract: A manufacturing method and manufacturing device for micronutrient supplement granules involve sequentially performing physically extruding, grinding and sieving of trace elements to obtain micronutrient supplement granules having a granule size of 35-380 ?m and a granule strength greater than 10 N with a tablet press, a first grinding and granulating machine and a sieving unit including primary and secondary sieving machines. A discharge end of the tablet press is connected to a feed end of the first grinding and granulating machine, of which a discharge end is connected to a feed end of the sieving unit. Feed and discharge ends of the primary sieving machine are respectively connected to discharge end of the first grinding and granulating machine and feed end of the secondary sieving machine. The primary and secondary sieving machines have sieving meshes respectively with square and circular mesh holes.