Abstract: Fly-by-wire vehicle systems and related user interface devices are provided for controlling operation of a vehicle, such as an aircraft. An exemplary user interface includes a first linkage and a second linkage coupled to the first linkage. The first linkage is actuatable about a first pivot point and the second linkage is actuatable about a second pivot point independent of actuation of the first linkage about the first pivot point. The user interface includes a sensing arrangement configurable to obtain a first orientation of the first linkage with respect to a first reference orientation associated with the first pivot point, obtain a second orientation of the second linkage with respect to a second reference orientation associated with the second pivot point, and determine an input command based at least in part on the first orientation and the second orientation.

Abstract: Systems and related operating methods are provided for landing an aircraft. An exemplary method involves determining an amount of available energy associated with an energy source onboard the aircraft is less than a predicted amount of energy required to land the aircraft in accordance with a flight plan or other procedure currently being flown. Thereafter, the method automatically operates the aircraft to descend using an unregulated vertical speed using a first control scheme to regulate an orientation of the aircraft to a reference orientation. Thereafter, when the altitude of the aircraft is below a threshold, the method automatically operates the aircraft to descend using a different control scheme to regulate a lateral position of the aircraft to a lateral trajectory to a landing location while regulating a velocity of the aircraft using a cost function.

Abstract: Fly-by-wire vehicle systems and related user interface devices are provided for controlling operation of a vehicle, such as an aircraft. An exemplary user interface includes a first linkage and a second linkage coupled to the first linkage. The first linkage is actuatable about a first pivot point and the second linkage is actuatable about a second pivot point independent of actuation of the first linkage about the first pivot point. The user interface includes a sensing arrangement configurable to obtain a first orientation of the first linkage with respect to a first reference orientation associated with the first pivot point, obtain a second orientation of the second linkage with respect to a second reference orientation associated with the second pivot point, and determine an input command based at least in part on the first orientation and the second orientation.

Abstract: The present disclosure provides for a preparation method of highly concentrated antibody solution that binds to human programmed death receptor 1 (PD1). This process is able to manufacture the high concentrated antibody solution by an ultrafiltration/diafiltration (UF/DF) unit operation described herein. The UF/DF preparation method comprises mainly a first ultrafiltration concentration step, a buffer solution diafiltration step, and a second ultrafiltration concentration step. The process has a broad operation parameter range and maintains antibody stability and integrity when compared to low concentration antibody preparation.