Abstract: A high aspect ratio in-plane metal microneedle array, a manufacturing method and a clamping and inserting auxiliary device thereof is disclosed. A large-size metal sheet is cut into small metal sheets. A clamping tooling composed of two upper and lower metal cover plates is processed. Inner sides of the upper and the lower cover plates of the tooling are provided with grooves in which the metal sheets are placed and fastened by bolts. Wire cutting is conducted on the tooling and the metal sheets as a whole to obtain a plane metal microneedle array with a plurality of microneedle bodies. In addition, an assembling and clamping device and an inserting auxiliary device of the high aspect ratio in-plane metal microneedle array is provided. The assembled inserting auxiliary device is placed on skin, and the microneedle array is inserted into the skin through the auxiliary device.

Abstract: Provided in the present invention is a series of selective Factor XIa (FXIa) inhibitors, relating to the technical field of chemical drugs. The present invention also relates to pharmaceutical compositions containing said compounds and a use of said compounds in drugs for the treatment of diseases such as thromboembolism.

Abstract: A RET inhibitor, a pharmaceutical composition thereof and uses thereof including a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Furthermore, a pharmaceutical composition including the compound, and uses of the compound and pharmaceutical composition thereof in the manufacture of a medicament for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.

Abstract: A RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, the present invention provides a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. The invention also relates to a pharmaceutical composition including the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.

Abstract: A wearable equipment is adapted for substation maintenance mobile inspection and includes a binding strap and a controlling wireless communication module. A thermal imager is disposed on one side of the binding strap. A prism display component and a voice interaction module are disposed on the other side of the binding strap. The thermal imager, the prism display component, and a microphone and a speaker of the voice interaction module are connected to the controlling wireless communication module through cables, to transmit information in a power system intranet. An application method includes mounting the wearable equipment to an electric power helmet, and automatically sending an infrared image, a visible light image, power monitoring information, voice, and a video in a power operation area to a background management controlling system for the substation maintenance mobile inspection.

Abstract: A wearable equipment is adapted for substation maintenance mobile inspection and includes a binding strap and a controlling wireless communication module. A thermal imager is disposed on one side of the binding strap. A prism display component and a voice interaction module are disposed on the other side of the binding strap. The thermal imager, the prism display component, and a microphone and a speaker of the voice interaction module are connected to the controlling wireless communication module through cables, to transmit information in a power system intranet. An application method includes mounting the wearable equipment to an electric power helmet, and automatically sending an infrared image, a visible light image, power monitoring information, voice, and a video in a power operation area to a background management controlling system for the substation maintenance mobile inspection.