Abstract: A RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, the present invention provides a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. The invention also relates to a pharmaceutical composition including the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.

Abstract: A RET inhibitor, a pharmaceutical composition thereof and uses thereof including a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Furthermore, a pharmaceutical composition including the compound, and uses of the compound and pharmaceutical composition thereof in the manufacture of a medicament for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.

Abstract: Disclosed are a compound of formula (I), a preparation method therefor, and a medical application thereof. In particular, provided are the compound of formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof. These compounds are agonists of a glucagon-like peptide-1 receptor (GLP-1R). The present invention also relates to a pharmaceutical composition containing these compounds and use of the compound in a drug for treating diseases such as diabetes.

Abstract: Provided in the present invention is a series of selective Factor XIa (FXIa) inhibitors, relating to the technical field of chemical drugs. The present invention also relates to pharmaceutical compositions containing said compounds and a use of said compounds in drugs for the treatment of diseases such as thromboembolism.

Abstract: A RET inhibitor, a pharmaceutical composition thereof and uses thereof including a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Furthermore, a pharmaceutical composition including the compound, and uses of the compound and pharmaceutical composition thereof in the manufacture of a medicament for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.

Abstract: A RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, the present invention provides a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. The invention also relates to a pharmaceutical composition including the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.

Abstract: A wearable equipment is adapted for substation maintenance mobile inspection and includes a binding strap and a controlling wireless communication module. A thermal imager is disposed on one side of the binding strap. A prism display component and a voice interaction module are disposed on the other side of the binding strap. The thermal imager, the prism display component, and a microphone and a speaker of the voice interaction module are connected to the controlling wireless communication module through cables, to transmit information in a power system intranet. An application method includes mounting the wearable equipment to an electric power helmet, and automatically sending an infrared image, a visible light image, power monitoring information, voice, and a video in a power operation area to a background management controlling system for the substation maintenance mobile inspection.

Abstract: A wearable equipment is adapted for substation maintenance mobile inspection and includes a binding strap and a controlling wireless communication module. A thermal imager is disposed on one side of the binding strap. A prism display component and a voice interaction module are disposed on the other side of the binding strap. The thermal imager, the prism display component, and a microphone and a speaker of the voice interaction module are connected to the controlling wireless communication module through cables, to transmit information in a power system intranet. An application method includes mounting the wearable equipment to an electric power helmet, and automatically sending an infrared image, a visible light image, power monitoring information, voice, and a video in a power operation area to a background management controlling system for the substation maintenance mobile inspection.