Abstract: About 5-10% of all fractures result in delayed or impaired healing. Impaired bone fracture is difficult for the patient, and is very expensive for the medical system. The present disclosure provides methods of treating impaired bone fracture healing comprising administration of an effective amount of progranulin or progranulin derivatives to a subject suffering from delayed or impaired bone fracture healing. The disclosure also provides medical compositions and formulations comprising progranulin or progranulin derivatives to be used in the treatment of impaired bone fracture healing.