Abstract: The resorption of a medical implant can be controlled with the use of particles embedded in a resorbable bulk material forming the implant or portion thereof. The implant can be removed from a body of a mammal by natural biological mechanisms after use. The resorption of the implant can involve swelling and/or hydrolyzing of the particles within the implant upon contact with a body fluid such that porosity and flow of fluid within the bulk material of the implant is increased. Resorption of the implant may also involve the use of particles with magnetic properties embedded within the implant such that an applied magnetic field causes the particles to vibrate within the bulk material thereby increasing the porosity and thus the flow of fluid, hence facilitating resorption of the implant. The resorption rate of the implant can be controlled by modulating swelling, hydrolysis, or movement of the embedded particles.

Abstract: The invention relates to bulking agents and apparatus and methods for using the disclosed bulking agents. The bulking agents can be used to treat such conditions as urinary and fecal incontinence, gastro-esophageal reflux, aneurismal blockages, and cosmetic deformities. The invention also relates to an injection method that reduces the injection pressure required to place the bulking agents.

Abstract: According to an aspect of the present invention, a medical device is provided, which comprises the following: (a) a hollow elongate body (e.g., a elongate cylinder, such as a needle) having distal and proximal ends; and (b) a rotatable member comprising a tissue morselizer and an elongate shaft (e.g., an auger-like tissue-drilling bit). In the devices of the present invention, the elongate shaft is disposed within the hollow elongate body and cooperates with the hollow elongate body to (i) advance material (e.g., morselated tissue) toward the proximal end of the hollow elongate body when the shaft is rotated in a first direction, and (ii) advance material (e.g., a therapeutic agent and/or a bulking agent) toward the distal end of the hollow elongate body when the shaft is rotated in a second direction that is opposite the first direction.

Abstract: According to one claim of the invention, a method for occluding a fallopian tube in a vertebrate subject is described, which comprises comprising transcervically delivering a solid blocking material into the fallopian tube. In various embodiments, a fluid sealing material is delivered along with the solid blocking material. Other claims of the invention pertain to articles of manufacture, delivery devices and kits for use in occluding the fallopian tubes of a vertebrate subject.

Abstract: According to an aspect of the present invention, a medical device is provided, which comprises the following: (a) a hollow elongate body (e.g., a elongate cylinder, such as a needle) having distal and proximal ends; and (b) a rotatable member comprising a tissue morselizer and an elongate shaft (e.g., an auger-like tissue-drilling bit). The device (i) advances material (e.g., morselated tissue) toward the proximal end of the hollow elongate body when the shaft is rotated in a first direction, and (ii) advances material (e.g., a therapeutic agent and/or a bulking agent) toward the distal end of the hollow elongate body when the shaft is rotated in a second direction that is opposite the first direction. The invention also provides a method of treatment for morselizing and removing tissue from within the patient and creating a void within the patient and introducing a therapeutic agent and/or a bulking agent into the void.

Abstract: A medical device for long-term implantation is provided, as well as a method of making the same and a method of treatment using the same. The medical device comprises (1) a reservoir including (a) a polymer matrix and (b) an antimicrobial agent disposed within the polymer matrix, wherein the reservoir is adapted for long-term release of the antimicrobial agent from the polymer matrix; and (2) a surfactant region disposed over the reservoir at an outer surface of the device.

Abstract: In some embodiments, a ureteral stent includes an elongate member having a first portion and a second portion, which is coupled to the first portion. The first portion of the elongate member is configured to be disposed within a kidney of a patient. The second portion of the elongate member, which has a sidewall that defines a lumen, is configured to deliver fluid from a first location of the sidewall of the second portion to a second location of the sidewall of the second portion via capillary action. The second portion of the elongate member is configured to be disposed within at least one of a bladder and a ureter of the patient.

Abstract: In some embodiments, a stent includes an elongate member and a distal retention member. The elongate member is configured to be disposed within a ureter of a patient and has a first portion, a second portion and a plurality of beads bonded together. The plurality of beads define a plurality of spaces between the plurality of beads. The plurality of spaces are configured to allow fluid to flow from the first portion of the elongate member to the second portion of the elongate member. The distal retention member is configured to help maintain a portion of the stent within a kidney of the patient.

Abstract: Bioresorbable medical implants are designed to have different resorption rates over time or over the topography of the implants. The resorption of the medical implants are controlled by including layers having differing resorption rates. The layers resorb sequentially over time through sequential exposure to body fluids. A resorption-controllable medical implant includes a series of two or more layers. The first layer includes a first bioresorbable material. The second layer includes a second bioresorbable material and resorbable particles of a first kind dispersed within the second bioresorbable material. Additional layers of bioresorbable material alone or including resorbable particles may be added to slow or speed resorption and achieve desired control over the resorption of the implant. Resorbable particles can be added in differing amounts or kinds in various segments of the implant to provide topographically differing resorption rates.

Abstract: A steerable medical device is used to controllably introduce a guidewire or other medical instrument into a body of a patient and direct placement of the guidewire or other medical instrument in the body of the patient. The steerable medical device can include an elongated member, a steering mechanism, and an attachment member. The elongated member extends along a longitudinal axis and comprises a deflectable distal portion that is deflectable off of the longitudinal axis. The steering mechanism is adapted to control longitudinal and rotational movement of the elongated member and to control off-axis deflection of its deflectable portion. The attachment member is removably couplable to another medical device. The attachment member is moveably coupled to the steering mechanism and the elongated member.

Abstract: According to an aspect of the present invention, medical devices are provided whose surfaces are partially covered with a coating that further comprises silver nanoparticles. Other aspects of the invention pertain to methods of making and using such medical devices.

Abstract: According to an aspect of the present invention, implantable medical articles are provided, which comprise a surgical mesh that is at least partially covered with a coating that comprises a radiopaque material such as a metal or a metallic compound. The radiopaque material is present in the coating in an amount such that the coated portions of the mesh are visible using radiographic imaging techniques. Other aspects of the invention pertain to methods of making and using such medical articles.

Abstract: A method of treating tissue includes placing substantially spherical polymer particles in the tissue. The particles include an interior region having relatively large pores and a first region substantially surrounding the interior having fewer relatively large pores than the interior region.

Abstract: Bioresorbable medical implants are designed to have different resorption rates over time or over the topography of the implants. The resorption of the medical implants are controlled by including layers having differing resorption rates. The layers resorb sequentially over time through sequential exposure to body fluids. A resorption-controllable medical implant includes a series of two or more layers. The first layer includes a first bioresorbable material. The second layer includes a second bioresorbable material and resorbable particles of a first kind dispersed within the second bioresorbable material. Additional layers of bioresorbable material alone or including resorbable particles may be added to slow or speed resorption and achieve desired control over the resorption of the implant. Resorbable particles can be added in differing amounts or kinds in various segments of the implant to provide topographically differing resorption rates.

Abstract: According to one aspect of the invention, ureteral stents are provided that comprise an elongated stent body and a urologically beneficial agent. The elongated stent body comprises a kidney portion adapted to occupy the kidney of a subject upon implantation, a ureter portion adapted to occupy the ureter of a subject upon implantation, and a bladder portion adapted to occupy the bladder of a subject upon implantation. The ureteral stents of the invention are adapted to release the urologically beneficial agent into the subject. Moreover, the amount of urologically beneficial agent that is released varies along the length of the stent. Other aspects of the invention pertain to methods of forming such stents and methods of using such stents.

Abstract: Techniques are described which decrease DRC (design rule check) marking time, e.g., in a circuit interconnect router, by capitalizing on repetitious relationships between interconnect elements (and/or circuit components) in a circuit design, by recording previously calculated markings and reusing the markings on subsequent marking iterations or processes. Marking information corresponding to each marking point includes indications of what types of interconnect elements or circuit components can be positioned at the marking point location without violating a design rule. With a dynamic caching process, once the marking computations have been completed for an element and the corresponding points in the vicinity, those values are stored in a cache. The next time the router encounters another instance of a known element-to-point relationship, the stored values are reloaded and applied to the current point.

Abstract: The present invention discloses a method for inspecting an object using multi-energy radiations and an apparatus thereof. The method comprises the steps of: causing multi-energy radiations to interact with an object under inspection; detecting and recording detection values after an interaction between the multi-energy radiations and the object under inspection; substituting a portion of the detection values into a predetermined calibration function to obtain information comprising primary material attribute; and determining further material attributes of the object by applying a set of functions suitable for a energy band corresponding to the information. The present invention is applicable to the large container cargo inspection without opening containers at customs, ports and airports.

Abstract: According to one aspect, the present invention is directed to implantable or insertable medical devices which comprise polymeric regions that comprise high vinyl acetate content EVA (or another soft polymer) and a therapeutic agent. In another aspect, the present invention is directed to implantable or insertable medical devices which comprise (a) a first region comprising a first EVA and (b) a second region adjacent to the first region that is of lower durometer than the first region.

Abstract: In one embodiment, a method includes securing an implant that includes a pre-formed loop to a vaginal apex. An end of the suture is inserted through a selected portion of a pelvic tissue to dispose at least a portion of the implant within a pelvic region of the patient. The end of the suture is drawn through the loop while simultaneously advancing a uterus to approximate the vaginal apex to the selected portion of pelvic tissue. An apparatus includes an implant and a suture coupled to the implant having a pre-formed loop. configured to receive a portion of a delivery device therethrough. A trocar is coupled to an end of the suture that can be releasably coupled to an end of the delivery device. The trocar can be inserted through a pelvic tissue and drawn through the loop forming a knot to secure the implant to the pelvic tissue.

Abstract: According to one aspect, the present invention provides a substantially two-dimensional surgical mesh comprising a base material, a first area having a first characteristic and a second area having a second characteristic that differs from the first characteristic. The surgical mesh may further comprise a third area having a third characteristic that may be the same as or different from the first and second characteristics, and so on.