Abstract: A positioning device for arrangement of a basin false bottom in ocean engineering comprises a laser transmitting system, a rotating platform system, and a control and calculation system. The laser transmitting system comprises a laser transmitter used for providing laser beams. The rotating platform system comprises a two-degree-of-freedom rotating platform used for carrying the laser transmitter and making the laser beams have spatially arbitrary directivity. The control and calculation system is used for calculating, according to given coordinates, the angle by which the two-degree-of-freedom rotating platform needs to rotate, controlling rotation of the two-degree-of-freedom rotating platform, and making the laser beams transmitted by the laser transmitter accurately indicate the given coordinates at the basin false bottom.

Abstract: This disclosure relates to modulation of the interactions between proNTs and p75NTR/SorCS2 expressed on neuronal cells. Inhibition of such interactions is useful for reducing unwanted synaptic elimination, neurite pruning and/or other neuronal structural collapses, and for treating early stage and mild neurological disorders including mild cognitive impairment.