Abstract: The present invention provides a coating additive copolymer comprising, as copolymerized units, by dry weight based on total dry weight of the copolymer, from 20% to 60%, at least one acetoacetoxy or acetoacetamide functional ethylenically unsaturated monomer, and from 40% to 80% at least one water soluble ethylenically unsaturated monomer. It further provides a coating formulation comprising higher than 0.04% by dry weight based on total dry weight of the coating formulation, the acetoacetoxy or acetoacetamide functional ethylenically unsaturated monomer.

Abstract: Disclosed is a kit for detecting drug resistance of cetuximab in the treatment of metastatic colorectal cancer. The kit comprises a substance used for detecting gene mutations in Exon 19 of the PIK3CA gene, and may further comprise a specification recording the following contents: if Exon 19 in the PIK3CA gene of a patient with metastatic colorectal cancer as a subject to be tested, who is intended to receive cetuximab treatment or is receiving cetuximab treatment and does not have drug resistance, has at least one of K944N, F930S, V955G, V955I, and K966E mutations, the subject to be tested will develop drug resistance or will be a candidate to develop drug resistance when receiving or continuing to receive cetuximab for treating metastatic colorectal cancer.

Abstract: An aqueous dispersion, an aqueous coating composition comprising the aqueous dispersion, and coatings made therefrom capable of slow release of fragrance.

Abstract: An aqueous dispersion having reduced VOCs and/or odor and an aqueous coating composition comprising the aqueous dispersion.

Abstract: The present invention provides a coating composition comprising a polymer binder and from 1% to 40% by dry weight based on total dry weight of the coating composition, titanium dioxide particles, wherein the polymer binder comprises, as polymerized units, by dry weight based on total dry weight of the polymer binder, from 50% to 99%, ethylenically unsaturated nonionic monomers, and from 1% to 5%, a vinyl functionalized benzotriazole.

Abstract: Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.

Abstract: An aqueous coating composition having good freeze-thaw stability and providing coatings with good stain resistance.

Abstract: Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.

Abstract: A process of stripping a dispersion of organic extender particles with volatile organic compounds and a method of reducing volatile organic compounds.

Abstract: A novel coating composition comprising, by dry weight based on total dry weight of the coating composition, i) from 20% to 45% of emulsion copolymer being a copolymerization product of a monomer mixture comprising, by dry weight based on the total dry weight of the emulsion copolymer, from 30% to 80%, of ethyl acrylate; from 20% to 70%, of a vinyl monomer; and from 1% to 4%, of an ethylenically unsaturated carboxylic acid containing monomer; ii) from 0.5% to 5% of a paraffin wax; iii) from 30% to 55% of a pigment; and iv) from 0.003% to 0.5% of lithium hydroxide.

Abstract: Disclosed are methods for treating a solid tumor, such as a neuroendocrine tumor, in a patient comprising administration to the patient in need thereof a therapeutically effective amount of a compound that is an inhibitor of VEGFR 1, 2, and 3, FGFR 1, and CSF1R, such as N-(2-(dimethylamino)ethyl)-1-(3-((4-((2-methyl-1H-indol-5-yl)oxy)pyrimidin-2-yl)amino)phenyl)-methanesulfonamide.

Abstract: This invention generally relates to a coating composition which provides a coating film with high hydrophilic resistance and high hydrophobic resistance. The coating composition contains a polymer formed from a monomer composition comprising (a) 45-85 wt % of ethyl ester of acrylic acid or methacrylic acid and (b) 15-54 wt % of itaconic ester with 1 or 2 carbon atoms as a binder of the coating composition, and the weight of sum of (a) and (b) is 65% or more based on the total weight of the polymer.

Abstract: Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.

Abstract: The present invention provides a novel aqueous coating composition comprising a multi-stage aqueous emulsion polymer, an anionic colloidal silica, and a thickener. This novel aqueous coating composition provides low gloss, while maintaining good physical stability and transparency.

Abstract: Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.

Abstract: The present invention provides a coating composition comprising a polymer binder and from 1% to 40% by dry weight based on total dry weight of the coating composition, titanium dioxide particles, wherein the polymer binder comprises, as polymerized units, by dry weight based on total dry weight of the polymer binder, from 50% to 99%, ethylenically unsaturated nonionic monomers, and from 1% to 5%, a vinyl functionalized benzotriazole.

Abstract: The present invention provides a polymer dispersion comprising by dry weight based on total dry weight of the polymer particles, a) from 60% to 95% a vinyl acetate monomer, b) from 0.2% to 2.5% a phosphorus-containing allylic monomer; and c) from 0.2% to 2.5% an itaconic acid monomer; wherein the total amount of monomers b) and c) is from 0.5% to 2.5% by dry weight based on total dry weight of the polymer particles, and the dry weight ratio of monomer b) to monomers b) and c) is from 0.2 to 0.6. The present invention further provides a paint formulation of PVC higher than 60% comprising the polymer dispersion.

Abstract: A method of preparing a polymer dispersion comprising (i) contacting an aqueous dispersion of de-ionized acidic colloidal silica particles with a first mixture of monomers to form a combination; (ii) polymerizing such combination at an initial pH of from 2 to 5 to at least 90% in completion; and (iii) adding a second mixture of monomers at a rate substantially equal to the rate of consumption of such second mixture of monomers to continue and complete the polymerization. The present invention further provides a polymer dispersion made from the above method.

Abstract: An aqueous coating composition capable of providing coating films with balanced properties of high hardness, high clarity, good water resistance, and good alcohol resistance; and a process of making such aqueous coating composition.

Abstract: Small molecule stimulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing cancer. Also provided are methods for stimulating SRC family proteins in a cell.