Abstract: A positioning method and a positioning apparatus are provided. The positioning method is applied to a lock end and includes the following. The lock end sends first information and records a first sending moment of the first information. The key end receives the first information, records a first receiving moment, and sends second information to the lock end, where the second information includes request information, a second sending moment of the request information, and the first receiving moment. The lock end receives the second information, records a second receiving moment, and calculates a difference between the second sending moment and the first receiving moment. The lock end calculates a distance between the lock end and the key end according to the first sending moment, the second receiving moment, and the difference between the second sending moment and the first receiving moment.

Abstract: Techniques are provided for near real-time anomaly event detection and classification with trend change detection for smart water grid operation management. In the first phase, a trend change is detected in each of one or more sensors by comparing new sensor data of a sensor with a historical trend pattern of the same sensor. In the second phase, and after the trend changes are detected, a valid event evaluation time window can be determined based on combining and analyzing the detected trend changes for flow and pressure sensors, e.g., at least one flow sensor and at least one pressure sensor from the same supply zone of the smart water grid. The valid event evaluation time window can be used with anomaly events that are detected in near-real time to classify the anomaly events in near-real time as valid, e.g., true anomaly events, or invalid, e.g., false alarms.

Abstract: The present disclosure provides a method for knocking out an N-myristoyltransferase (NMT) gene from Eimeria tenella, and belongs to the technical field of microorganisms. The method includes: mixing sporozoites of Eimeria tenella with a pCRISPR::EtNMT plasmid and a pEtNMT::DHFR plasmid, and subjecting a resulting mixture to electrotransformation to obtain NMT gene-knockout Eimeria tenella. The method provided by the present disclosure can successfully knock out the NMT gene from Eimeria tenella, which lays a foundation for studying the function of the Eimeria tenella gene and developing a vaccine therefor.

Abstract: The invention provides a deposition machine, which comprises a chamber, a first pipeline and a second pipeline, wherein one end of the first pipeline and one end of the second pipeline are connected to the chamber, and a part of the second pipeline passes through a sidewall of the first pipeline and extends into the interior of the first pipeline. The deposition machine has the advantages of reducing the risk of pipeline blockage.

Abstract: The present disclosure provides a method for knocking out an N-myristoyltransferase (NMT) gene from Eimeria tenella, and belongs to the technical field of microorganisms. The method includes: mixing sporozoites of Eimeria tenella with a pCRISPR::EtNMT plasmid and a pEtNMT::DHFR plasmid, and subjecting a resulting mixture to electrotransformation to obtain NMT gene-knockout Eimeria tenella. The method provided by the present disclosure can successfully knock out the NMT gene from Eimeria tenella, which lays a foundation for studying the function of the Eimeria tenella gene and developing a vaccine therefor.

Abstract: A marker for health assessment, and an application thereof, relating to the field of medical test. An application of a marker identification reagent in preparation of a reagent for measuring the health of a mammal, comprising: (1) measuring a marker in a test sample, wherein the marker is the level of 8-oxoGsn; and (2) comparing the marker with a reference, wherein the difference between the marker and the reference is used for assessing the health condition of the subject. According to the invention, comprehensive health condition assessment is performed on a subject by means of a simple clinical examination method, and the health condition and health laws of people can be obtained timely and quickly; compared with conventional medical test methods, the invention has remarkable advantages in detection and early warning of sub-health, disease treatment effect monitoring, and psychological emotional state detection in the field of health service management.

Abstract: The present invention discloses a medicament for the prevention and treatment of tumors, in particular relating to the use of 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) in the manufacturing of a medicament for the prevention and treatment of tumors, and a medicament comprising 8-oxo-dGTP for the prevention and treatment of tumors, and falls within the pharmaceutical field. The 8-oxo-dGTP can be used in the manufacturing of a medicament for at least one of the treatment, prevention and control of tumors. The 8-oxo-dGTP has a significant inhibitory effect on tumorigenesis and tumor cell proliferation for many types of tumors, and can serve as a new candidate medicament for the prevention and treatment of tumors. Animal experiments show that the 8-oxo-dGTP is significantly superior to 5-FU in terms of tumor inhibition, therefore has a good industrial availability and great business and social values.

Abstract: The present invention discloses a medicament for the prevention and treatment of tumors, in particular relating to the use of 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) in the manufacturing of a medicament for the prevention and treatment of tumors, and a medicament comprising 8-oxo-dGTP for the prevention and treatment of tumors, and falls within the pharmaceutical field. The 8-oxo-dGTP can be used in the manufacturing of a medicament for at least one of the treatment, prevention and control of tumors. The 8-oxo-dGTP has a significant inhibitory effect on tumorigenesis and tumor cell proliferation for many types of tumors, and can serve as a new candidate medicament for the prevention and treatment of tumors. Animal experiments show that the 8-oxo-dGTP is significantly superior to 5-FU in terms of tumor inhibition, therefore has a good industrial availability and great business and social values.

Abstract: A fast toasting toaster and a method for control the same are disclosed. The fast toasting toaster comprises a machine core assembly, a sliding rack assembly, a heating tube assembly, and a housing fixed onto a base, the mechanism core assembly comprising a front side plate, a side plate, and a rear side plate, the front side plate, the side plate and the rear side plate being fixed and coupled to form the machine core and then being fixed onto the base, the heating tube assembly being fixed onto the front side plate and the rear side plate and being positioned between the front side plate and the rear side plate, the sliding rack assembly comprising a sliding rack and a toast rack fixed onto the sliding rack.

Abstract: There are provided compounds of the formula or the pharmaceutically acceptable salts thereof, wherein X, Y, Z, V1, V2, R1, R2, R3, R4 and R5 are herein described. These compounds are useful as anticancer agents.

Abstract: A pillow that can be manipulated into a variety of bent/folded/twisted configurations and can retain each of those configurations until manipulated into a different configuration. The pillow has a segmented toroidal shape and includes an envelope and a flowable fill filling the envelope so that the fill is under positive pressure throughout. The pillow has a plurality of constrictions that, in conjunction with the pressurized fill, provides the pillow with soft hinges that facilitate bending/folding/twisting of the pillow.

Abstract: The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.

Abstract: A pillow that can be manipulated into a variety of bent/folded/twisted configurations and can retain each of those configurations until manipulated into a different configuration. The pillow has a segmented toroidal shape and includes an envelope and a flowable fill filling the envelope so that the fill is under positive pressure throughout. The pillow has a plurality of constrictions that, in conjunction with the pressurized fill, provides the pillow with soft hinges that facilitate bending/folding/twisting of the pillow.

Abstract: The present invention provides PLK1 inhibitor compounds of formula I: useful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the treatment or control of solid tumors, such as, for example, breast, colon, lung and prostate tumors and other oncological diseases such as non-Hodgkin's lymphomas. Also provided are intermediate compounds useful in the synthesis of compounds of formula I.

Abstract: The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.

Abstract: The present invention provides PLK1 inhibitor compounds of formula I: useful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the treatment or control of solid tumors, such as, for example, breast, colon, lung and prostate tumors and other oncological diseases such as non-Hodgkin's lymphomas. Also provided are intermediate compounds useful in the synthesis of compounds of formula I.

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.

Abstract: Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R7 have the significances given in the description and claims can be used in the form of pharmaceutical compositions.

Abstract: There are provided compounds of the formula or the pharmaceutically acceptable salts thereof, wherein X, Y, Z, V1, V2, R1, R2, R3, R4 and R5 are herein described. These compounds are useful as anticancer agents.

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.