Abstract: Provided are small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. Further provided are methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating diseases or disorders related to USP1, such as cancers.

Abstract: The disclosure discloses a liquid metal packaging structure for chip heat dissipation, comprising: a fixing frame and a sealing frame, wherein a chip is provided in the inner frame of the sealing frame, and a heat sink is provided on side of the sealing frame away from the electronic component, and the heat sink is hermetically covered on an end surface of the sealing frame, the sealing frame is filled with liquid metal, and the heat sink is integrally molded with a pressing block at a position corresponding to the inner frame of the sealing frame, and the liquid metal is arranged between the chip and the pressing block. According to the liquid metal packaging structure for chip heat dissipation, the sealing frame is fixed by the fixing frame, and the sealing frame is filled with liquid metal.

Abstract: A biaxially oriented multilayer film having a core layer that includes a polyethylene-based composition. The core layer has: a melt index (I2) that is from 0.2 g/10 min to 5.0 g/10 min; a density that is between 0.930 g/cm3 and 0.956 g/cm3; and an average short chain branch (SCB) level in the portion between log (Mw) of 4.0 to 5.0 (SCBlogMw4-5) that is greater than 3.5 SCB/1000c and less than 10.0 SCB/1000 C. The biaxially oriented multilayer film also includes at least one additional layer that includes a propylene-based composition.

Abstract: This application provides a method and apparatus for recommending a media sharing room, an electronic device, a computer-readable storage medium, and a computer program product. The method includes determining, in response to a request to join a media sharing room by a target object, a recommended area associated with a to-be-recommended media sharing room; generating a first Bloom filter array corresponding to a location of the recommended area, and transmitting the first Bloom filter array to a terminal of the target object; receiving, from the terminal, a result indicating whether the target object is located in the recommended area, the result being determined based on the first Bloom filter array and a second Bloom filter array, and the second Bloom filter array corresponding to a location of the target object; and recommending the media sharing room when the result indicates that the target object is located in the recommended area.

Abstract: Provided are small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. Provided are methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating diseases or disorders related to USP1, such as cancer.

Abstract: The present disclosure provides a method of treating cancer, comprising administering an anti-LAIR1 antibody to a subject suffering from a cancer that is resistant to checkpoint inhibitor blockade therapy.

Abstract: The present application discloses a data secrecy method for a submarine cable system with a failure and a submarine cable system. The method includes: determining a first disaster tolerance set in response to that a failure occurs to a first branch; and replacing a target optical signal in a first optical signal with a virtual optical signal. The first branch is any branch in the submarine cable system. The first disaster tolerance set includes at least one wavelength used for optical signals for transfer from a first terminal station to the first branch. The first optical signal is an optical signal output from the first terminal station. The target optical signal includes optical signals corresponding to the respective wavelengths in the first disaster tolerance set. The virtual optical signal is an optical signal that does not carry data content.

Abstract: Techniques for data processing involve: performing, according to a determination that a programmable circuit receives user-written data, data feature detection by the programmable circuit on a first part of the user-written data. Such techniques further involve: replacing, in response to the first part matching a predetermined data feature, the first part by the programmable circuit with a data representation corresponding to the predetermined data feature. In addition, such techniques involve: writing the data representation to a cache region of a storage system. Accordingly, such techniques can save cache resources of a storage system and can save CPU of the storage system, thus avoiding the latency due to data feature detection and improving the user experience.

Abstract: A method for reducing inline directivity of an air-gun source signature by optimizing spatial distribution of air-guns is provided according to the present application, which relates to a field of design and optimization of an air-gun source. An evaluation standard in the air-gun distribution in an air-gun array direction is proposed. By a combination optimization along both the inline and depth directions, a design scheme having evidently broader effective bandwidth and effective take-off angle width than a design scheme of a conventional source is obtained, with which the directivity of the air-gun source signature can be reduced.

Abstract: Provided is an aerosol generation device, the aerosol generation device comprising a chamber for receiving at least some of a smokable material; a magnetic field generator configured to generate a varying magnetic field; a susceptor configured to be penetrated by the varying magnetic field so as to generate heat, thereby heating the at least some smokable material received in the chamber; and a circuit configured to determine the temperature of the susceptor by acquiring a resistance value of the at least some of the material on the susceptor and on the basis of the resistance value. According to the aerosol generation device of the present application, the temperature of the susceptor is determined by measuring the resistance of the susceptor, and compared with a temperature measuring mode using a temperature sensor, production and preparation are more convenient and rapider, and the temperature measuring effect is more accurate.

Abstract: Systems and related methods for stationary digital chest tomosynthesis (s-DCT) imaging are disclosed. In some aspects, systems include a stationary x-ray source array with an array of x-ray pixels configured to generate x-ray beams at different viewing angles relative to a subject to be imaged that is stationary, a stationary area x-ray detector configured to record x-ray projection images of the subject, a physiological gating apparatus for monitoring at least one physiological signal of the subject and defining a physiological phase and a time window based on the at least one physiological signal, and a computing platform configured to activate the x-ray pixels based on the physiological phase and the time window and upon receipt of the at least one physiological signal from the physiological gating apparatus in order to synchronize x-ray exposure with the at least one physiological signal of the subject.

Abstract: The present disclosure belongs to the technical field of tools for bridge reinforcement, and particularly relates to a precisely-positioned drilling apparatus for steel tubular joints. According to the present disclosure, a lifting frame unit, an electric drill, a lever unit, a positioning tube unit, and a diagonal tensioning member unit are arranged on a base unit such that 1. during drilling, a drill rod is not prone to deviation, and a drilling action is relatively precise, resulting in an approximately circular shape of a final drilled hole; and 2. the above lever unit is essentially a labor-saving lever that ensures relatively easy and convenient drilling operations. Additionally, the present disclosure further discloses an application method of the apparatus, which ensures that the apparatus may stably fit with and be safely available for electric drills with various sizes and specifications.

Abstract: A livestreaming processing method includes: displaying a room interface of a media sharing room, the room interface including a main playing region and a secondary playing region, the secondary playing region including at least one livestreaming window, and each livestreaming window corresponding to a livestreaming object; playing media content in a media playing window in the main playing region, the media content being viewable by at least two objects joining the media sharing room, and the at least two objects including the livestreaming object; and playing, in each the at least one livestreaming window, livestreaming content of at least one livestreaming object corresponding to the at least one livestreaming window in the secondary playing region.

Abstract: A road boundary detection method and apparatus, and an electronic device, a storage medium and a computer program product are provided. The method includes that: a road image, which is collected by an image collection device arranged on a vehicle is identified, and then a plurality of road boundaries from the road image is determined; and a road boundary inside which the vehicle can travel is selected from the plurality of road boundaries.

Abstract: The present invention relates to a coating composition, a coating method and use of the composition, and a product coated with the coating composition. The coating composition comprises: (a) an isocyanate-reactive component; (b) an isocyanate component comprising: (b1) at least one isocyanate prepolymer, the isocyanate prepolymer being a reaction product of components comprising at least one aliphatic isocyanate and at least one polyether polyol, the polyether polyol having a weight-average molecular weight of 400 to 6000 and the structure of HO—R1n—R2; and (b2) at least one isocyanate oligomer containing not less than two isocyanate groups, the weight ratio of the isocyanate prepolymer (b1) to the isocyanate oligomer (b2) being greater than 1:4 and less than 4:1; and (c) a catalyst; wherein the molar ratio of the isocyanate groups to the isocyanate-reactive groups in the coating composition is from 1.5:1 to 4:1.

Abstract: Systems and methods for generating multi-view synthetic dental radiographs for intraoral tomosynthesis. In some embodiments, the method includes generating or receiving two-dimensional (2D) projection images, manipulating pixel values contained in each of the plurality of 2D projection images, reconstructing a three-dimensional (3D) image space from information available in the plurality of 2D projection images, the 3D image space comprising voxel values, manipulating the voxel values in the 3D image space using one or more tunable weighting algorithms that can be adjusted to emphasize one or more features of interest of each image in the 3D image space, generating a plurality of synthetic dental radiographs from multiple views using information available in the 3D image space, and displaying one or more of the synthetic dental radiographs. In some embodiments, the system includes a display in communication with an image processing system comprising one or more processors for performing the method.

Abstract: Disclosed are a testing system and testing method for a magnetic refrigerator. In the system, an adjustable load includes a heating container, and a flow direction control structure. The heating container is provided with an inlet, an outlet, and a heater with controllable heating power. The flow direction control structure is configured to enable a heat exchange fluid flowing out from a cold end of any magnetic regenerator module in magnetic regenerator modules arranged in pairs to flow into a cold end of another magnetic regenerator module through the inlet and outlet of the heating container in sequence, the heater is used to heat the heat exchange fluid inside the heating container, and an on-off state between the adjustable load and the cold end of any magnetic regenerator module is controllable.

Abstract: An offshore wind power single pile-friction wing composite foundation is provided, which includes a single pile and a friction wing being connected to the single pile through the force-conducting pipe, the tapered transition section of the single pile penetrates deep into the bearing stratum of the seabed, the force-conducting pipe of the friction wing located in the bearing stratum is in close contact with the tapered transition section of the single pile, the side wing of the friction wing is connected to the outer wall of the force-conducting pipe, and the ring wing is arranged inside the included angle of the side wing. There is a thorough structure in the axial direction of the friction wing, having convenience for embedding the bearing stratum of the seabed; the side wing and the ring wing support each other structurally to ensure the structural stability of the friction wing.