Abstract: In its many embodiments, the present invention provides certain 7-, 8-, and 10-substituted amino triazolo quinazoline derivatives of Formula (I): or a pharmaceutically acceptable salt thereof, wherein ring A, R1, R2, and R4 are as defined herein, pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other therapeutic agents), and methods for their preparation and use, alone and in combination with other therapeutic agents, as antagonists of A2a and/or A2b receptors, and their use in the treatment of a variety of diseases, conditions, or disorders that are mediated, at least in part, by the adenosine A2a receptor and/or the adenosine A2b receptor.

Abstract: Provided are multilayer structures and articles comprising same. The multilayer structure comprises: a biaxially-oriented polyethylene film comprising a skin layer with a matte surface and a core, the core comprising one or more core layers; a sealant film; and an adhesive adhering the sealant film to the matte surface of the skin layer of the biaxially-oriented polyethylene film. The multilayer structure can exhibit an enhanced adhesive bonding force in comparison to other multilayer structures.

Abstract: The polymer blend includes at least 90% by weight low density polyethylene (LDPE) polymer and from 1% to 10% by weight acid copolymer based on the total weight of the polymer blend. In the polymer blend, the LDPE polymer has a melt index (I? 2 #191) from 2 g/10 min to 8 g/10 min as determined in accordance with ASTM D1238, and a molecular weight distribution from 5 to 10.5. In the polymer blend, the acid copolymer is a polymerized reaction product of: at least 60% by weight ethylene, based on the total weight of the monomers present in the ethylene acid copolymer; from 1% to 20% by weight monocarboxylic acid monomer, based on the total weight of the monomers present in the ethylene acid copolymer; and from 0 to 20% by weight alkyl acrylate monomer, based on the total weight of the monomers present in the ethylene acid copolymer.

Abstract: A biaxially oriented multilayer film having a core layer that includes a polyethylene-based composition. The core layer has: a melt index (I2) that is from 0.2 g/10 min to 5.0 g/10 min; a density that is between 0.930 g/cm3 and 0.956 g/cm3; and an average short chain branch (SCB) level in the portion between log (Mw) of 4.0 to 5.0 (SCBlogMw4-5) that is greater than 3.5 SCB/1000c and less than 10.0 SCB/1000 C. The biaxially oriented multilayer film also includes at least one additional layer that includes a propylene-based composition.

Abstract: A laminate, an article comprising the laminate and a method for preparing the laminate are provided.

Abstract: Provided are a laminate material, an article comprising the laminate material and a method for preparing the laminate material. The laminate material, comprises a first substrate comprising at least one metalized PE-based film, a second substrate comprising at least one PE-based film, and an adhesive layer adhering the first substrate to the second substrate, wherein the adhesive layer is derived from a two-component solvent-based polyurethane adhesive composition, and wherein the concentration of fatty acids or fatty acid derivatives in the metalized PE-based film is less than 300 ppm, based on the total weight of the metalized PE-based film. The two-component solvent-based polyurethane adhesive composition comprises a polyester polyol component and a polyisocyanate component, wherein the polyol component has 40 wt %-60 wt % of aromatic rings in the backbone, based on the total weight of the polyester polyol and a Mw between 5.000 and 50.

Abstract: A first oriented film comprising a first polyethylene composition which comprises: from 20 to 50 wt % of a first linear low density polyethylene polymer having a density greater than 0.925 g/cc and an I2 lower than 2 g/10 min; and from 80 to 50 wt % of a second linear low density polyethylene polymer having a density lower than or equal to 0.925 g/cc and an I2 greater than or equal to 2 g/10 min; wherein the first polyethylene composition has an I2 from 0.5 to 10 g/10 min and a density from 0.910 to 0.940 g/cc is provided.

Abstract: In its many embodiments, the present invention provides certain 9-substituted amino triazolo quinazoline compounds of the structural Formula (I): and pharmaceutically acceptable salts thereof, wherein, ring A, R1 and R2 are as defined herein, pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other therapeutically active agents), and methods for their preparation and use, alone and in combination with other therapeutic agents, as antagonists of A2a and/or A2b receptors, and in the treatment of a variety of diseases, conditions, or disorders that are mediated, at least in part, by the adenosine A2a receptor and/or the adenosine A2b receptor.

Abstract: Embodiments of the present invention relate to multilayer structures and articles formed therefrom. In one aspect, a multilayer structure comprises (a) a biaxially oriented polyethylene film comprising a linear low density polyethylene having a density of 0.910 to 0.

Abstract: Provided herein is a laminate, comprising a polyolefin-based substrate film having a first inner surface and a first outer surface, and a polyurethane-based top coating having a second inner surface and a second outer surface, wherein the first inner surface is in contact with the second inner surface, wherein the polyurethane-based top coating is formed by mixing an isocyanate-terminated component and a hydroxyl-terminated component and coating the mixture onto the first inner surface of the polyolefin-based substrate film. Also provided are methods of preparing the laminate, articles comprising the laminate and use of the laminate in the packaging of a product.

Abstract: A process to form a polymer composition comprising an ethylene-based polymer and a functionalized ethylene-based polymer, said process comprising the steps described herein, which include passing a polymer melt through at least one static mixer, and wherein the functionalized ethylene-based polymer, in melt form, is introduced into the polymer melt, before the polymer melt enters the static mixer.

Abstract: The present disclosure is concerned with a method of forming a seal with a polyethylene based film structure. The polyethylene based film structure has at least one layer formed with an oriented polyethylene having a predetermined melting temperature (Tm). A conductive heat sealing device provides heat to form the seal, where a first sealing bar of the conductive heat sealing device operates at a first operating temperature of at least 10 degrees Celsius (° C.) below the Tm of the oriented polyethylene in the polyethylene based film structure and a second sealing bar of the conductive heat sealing device operates at a second operating temperature of at least 15° C. higher than the operating temperature of the first sealing bar. The seal formed with the polyethylene based film structure retains at least 99 percent of its original surface area prior to forming the seal.

Abstract: Provided are liners suitable for use in a bulk container. The liners can hold high temperature materials (e.g., materials reaching temperatures greater than 120° C.) and can comprise at least one ply including polyethylene. The liners can exhibit high dart impact and can provide a balance of stiffness, toughness, and seal strength. The at least one ply of the liner according to embodiments disclosed herein comprises a first layer, a tie layer, and a second layer, wherein the tie layer is disposed between the first layer and the second layer. In further embodiments, the at least one ply of the liner can include a second tie layer and a third layer, wherein the second tie layer is disposed between the first layer and the third layer.

Abstract: Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a ?-lactam antibiotic.

Abstract: Provided are multilayer structures and articles comprising same. The multilayer structure comprises: a biaxially-oriented polyethylene film comprising a skin layer with a matte surface and a core, the core comprising one or more core layers; a sealant film; and an adhesive adhering the sealant film to the matte surface of the skin layer of the biaxially-oriented polyethylene film. The multilayer structure can exhibit an enhanced adhesive bonding force in comparison to other multilayer structures.

Abstract: Provided are multilayer structures, laminates and articles formed from such structures. In one aspect, a multilayer structure comprises (a) a multilayer polyethylene film, wherein an outer layer of the film comprises a polymer blend of at least one ethylene-based polymer and at least one ethylene acid copolymer, wherein the difference between the melt index (I2) of the ethylene acid copolymer and the ethylene-based polymer is less than 18, and wherein the acid content of the polymer blend is greater than 0.2%; and (b) a metal layer comprising a metal deposited on the outer layer of the polyethylene film.

Abstract: A multilayer structure comprising a multilayer polyethylene film and a metal layer is provided, wherein an outer layer of the polyethylene film comprising 200 to 4000 ppm fluoroelastomer processing aid based on the weight of the outer layer, and the metal layer comprising a metal deposited on the outer layer of the polyethylene film. A laminate comprising the multilayer structure and an article comprising the laminate or the multilayer structure are also provided.

Abstract: A biaxially-oriented polyethylene (BOPE) multilayer film comprises a skin layer with a matte surface and a core, the skin layer with a matte surface comprising, in weight percent (wt %) based upon the weight of the skin layer: (1) from 20 to 80 wt % of an ethylene-based polymer, and (2) from 80 to 20 wt % of a propylene-based polymer; each of the ethylene-based polymer and the propylene-based polymer having a storage modulus, with a difference between the storage modulus of the ethylene-based polymer and the propylene-based polymer of greater than 40 megaPascals (MPa) at 110° C., and greater than 18 MPa at 120° C.

Abstract: In its many embodiments, the present invention provides certain 7-, 8-, and 10-substituted amino triazolo quinazoline derivatives of Formula (I): or a pharmaceutically acceptable salt thereof, wherein ring A, R1, R2, and R4 are as defined herein, pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other therapeutic agents), and methods for their preparation and use, alone and in combination with other therapeutic agents, as antagonists of A2a and/or A2b receptors, and their use in the treatment of a variety of diseases, conditions, or disorders that are mediated, at least in part, by the adenosine A2a receptor and/or the adenosine A2b receptor.

Abstract: A multilayer laminate (100) comprises an oriented polyethylene film (102), a biaxially oriented film (104) adhered to the oriented polyethylene film (102), a barrier film (106) adhered to the biaxially oriented film (104), and a multilayer polyethylene (PE) film (108) adhered to the barrier film (106). The biaxially oriented film (104) comprises one or more components selected from biaxially oriented polyamide (BOPA), biaxially oriented polyethylene terephthalate (BOPET), and biaxially oriented polypropylene (BOPP).