Patents by Inventor Jianqun Deng

Jianqun Deng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heparin skeleton synthase and its mutants and application
    Patent number: 11932881
    Abstract: A heparin skeleton synthase originates from Neisseria animaloris, with an amino acid sequence as shown in SEQ ID NO.2 and a nucleotide sequence of the coding gene as shown in SEQ ID NO.1. Its recombinant expression level is 6.8 times that of the existing heparin skeleton synthase KfiA from Escherichia coli K5, and total enzyme activity per fermentation liquor is 5.22 times that of the heparin skeleton synthase KfiA. The heparin skeleton synthase mutants obtained through site-directed mutagenesis of the sites No. 16, No. 25, No. 30, No. 111, No. 165, and No. 172 in the amino acid sequence of the said heparin skeleton synthase all have high expression levels.
    Type: Grant
    Filed: January 3, 2022
    Date of Patent: March 19, 2024
    Assignees: SHAN DONG UNIVERSITY, Bloomage Biotechnology Corporation Limited
    Inventors: Juzheng Sheng, Xueping Guo, Jianqun Deng, Fengshan Wang, Zhen Lu, Ranran Du, Liu Sun, Yuanjun Sun
  • HEPARIN SKELETON SYNTHASE AND ITS MUTANTS AND APPLICATION
    Publication number: 20220267746
    Abstract: A heparin skeleton synthase originates from Neisseria animaloris, with an amino acid sequence as shown in SEQ ID NO.2 and a nucleotide sequence of the coding gene as shown in SEQ ID NO.1. Its recombinant expression level is 6.8 times that of the existing heparin skeleton synthase KfiA from Escherichia coli K5, and total enzyme activity per fermentation liquor is 5.22 times that of the heparin skeleton synthase KfiA. The heparin skeleton synthase mutants obtained through site-directed mutagenesis of the sites No. 16, No. 25, No. 30, No. 111, No. 165, and No. 172 in the amino acid sequence of the said heparin skeleton synthase all have high expression levels.
    Type: Application
    Filed: January 3, 2022
    Publication date: August 25, 2022
    Inventors: Juzheng Sheng, Xueping Guo, Jianqun Deng, Fengshan Wang, Zhen Lu, Ranran Du, Liu Sun, Yuanjun Sun