Abstract: Antibodies, antigen-binding fragments and polypeptides that bind to HER2 are disclosed, as well as nucleic acids and vectors encoding the same. Also provided are cells comprising the antibodies, antigen-binding fragments, polypeptides, nucleic acids and vectors, methods of making such molecules, and the use of such molecules for therapeutic applications.

Abstract: The present disclosure relates to the technical field of alien invasive species control, in particular to use of 4-nitro-3-(trifluoromethyl)phenol in killing or controlling Pomacea canaliculata, a method for killing or controlling the Pomacea canaliculata, and a molluscicide. The present disclosure provides use of 4-nitro-3-(trifluoromethyl)phenol in killing or controlling Pomacea canaliculata. The 4-nitro-3-(trifluoromethyl)phenol can effectively control the Pomacea canaliculata with a low cost. In the present disclosure, the results of examples show that: the 4-nitro-3-(trifluoromethyl)phenol has an obvious killing effect on the Pomacea canaliculata, showing a control effect comparable to that of niclosamide, a commonly-used molluscicide for killing the Pomacea canaliculata.

Abstract: A method for optimizing group communication services, the method including determining a current location and an assigned home server for one or more devices associated with each of a plurality of group members, determining whether the one or more devices of the plurality of group members has moved to a visiting location, wherein the visiting location is a location outside of locations associated with the assigned home server based on the current location and assigned home server for the one or more devices, and assigning a group control application server associated with the visiting location to the to the one or more devices to serve as the assigned home server.

Abstract: A method for optimizing group communication services, the method including determining a current location and an assigned home server for one or more devices associated with each of a plurality of group members, determining whether the one or more devices of the plurality of group members has moved to a visiting location, wherein the visiting location is a location outside of locations associated with the assigned home server based on the current location and assigned home server for the one or more devices, and assigning a group control application server associated with the visiting location to the to the one or more devices to serve as the assigned home server.

Abstract: A method for optimizing group communication services, the method including determining a current location and an assigned home server for one or more devices associated with each of a plurality of group members, determining whether the one or more devices of the plurality of group members has moved to a visiting location, wherein the visiting location is a location outside of locations associated with the assigned home server based on the current location and assigned home server for the one or more devices, and assigning a group control application server associated with the visiting location to the to the one or more devices to serve as the assigned home server.

Abstract: Network and/or application resources can be dynamically instantiated based on service attributes and/or network capabilities. In one aspect, a customized and/or localized core slice can be selected that can deliver the requested service with target performance parameters. According to an aspect, dynamic selection, control, and/or management reporting can be provided for core network slices. Moreover, optimal core network slice selection can be performed to reduce network transport costs and efficiently deliver various services using an optimal core slice that matches a service profile being requested by an end user and/or device.

Abstract: The present invention relates to a stevioside M crystal form, a preparation method therefor and a use thereof, and specifically, relates to a naturally extracted high-intensity sweetener, i.e., a stevioside M crystal form A, the preparation method therefor and the user thereof. By means of comprehensive characterization of the new crystal form, the new crystal form is found to have advantages such as a high degree of crystallinity, good stability, and low hygroscopicity, and is applicable to a more comprehensive field of application. The preparation method in the present invention is simple and easy to operate, has high selectivity and good reproducibility, and can stably obtain the target crystal form.

Abstract: The present invention relates to the field of genetic engineering, particularly to a method for efficiently expressing pullulanase in Bacillus subtilis and recombinant Bacillus subtilis. said method includes steps of constructing modified Bacillus subtilis strain with deletion of alkaline protease gene and neutral protease gene, constructing expression vector including an optimized combination of promoter and signal peptide and pullulanase gene, and transforming said modified Bacillus subtilis strain with by said expression vector. A series of combinations of promoter and signal peptide are optimized to obtain the combination for efficiently expressing pullulanase, provide an industrial application basis.

Abstract: A method for optimizing group communication services, the method including determining a current location and an assigned home server for one or more devices associated with each of a plurality of group members, determining whether the one or more devices of the plurality of group members has moved to a visiting location, wherein the visiting location is a location outside of locations associated with the assigned home server based on the current location and assigned home server for the one or more devices, and assigning a group control application server associated with the visiting location to the to the one or more devices to serve as the assigned home server.

Abstract: A method for optimizing group communication services, the method comprising instantiating an adaptive homing tool as a virtual network function, the adaptive homing tool communicating with a centralized database in a multiple region telecommunications network; storing a user identification for plural group members in the database; when a service request is made by at least one group member that has moved outside of connectivity with a group home server, receiving group member location data for the plural group members in real time; assigning a group control application server to at least one group member when a group member initiates a service request; wherein the common service tool assigns the group application control server based on at least one of the priority data, group member location data, least network resources used, best path performance, shortest path performance, and quality of service.

Abstract: The disclosure relates to a co-crystal of tocopherol and proline and a preparation method thereof. The co-crystal is in a crystalline or partially crystalline form under normal pressure at room temperature. Compared with the existing tocopherol, the co-crystal has a higher melting point, better crystallinity, and has more excellent high-temperature stability, light stability, accelerated stability and long-term stability. The health products, food, cosmetics or feed products prepared by the present co-crystal have significantly improved stability. The present co-crystal maintains the excellent antioxidant property of tocopherol and can be widely used as an antioxidant in the fields of food, medicine and the like. The invention greatly improves the convenience in the use of tocopherol and saves the cost in the process of manufacturing, storage, transportation and use of tocopherol.

Abstract: A system that incorporates the subject disclosure may include, for example, receive a subscription from an application server where the subscription identifies a session event and/or sub-events occurring in a communication session for which the application server requests user location information, provide subscription information based on the subscription to core network nodes of the mobile communications network, receive user location information from the core network nodes responsive to a detection of a triggering event corresponding to the session event of the subscription, and provide the user location information to an IP multimedia subsystem network for delivery to the application server. Other embodiments are disclosed.

Abstract: The present disclosure relates to a cocrystal of telmisartan and hydrochlorothiazide, a preparation method and use thereof. In the cocrystal, the molar ratio of telmisartan and hydrochlorothiazide is 1:1. The cocrystal of telmisartan and hydrochlorothiazide was characterized by X-ray powder diffraction (XRPD), proton nuclear magnetic resonance spectra (1H-NMR), thermal gravimetric analysis (TG), scanning differential calorimetry (DSC) and infrared (IR) spectra, and it was found that the maximum plasma concentration of the cocrystal in SD rats was higher than that of any one of hydrochlorothiazide and telmisartan itself. The cocrystal of telmisartan and hydrochlorothiazide has a simple preparation method and good physical and chemical properties.

Abstract: Network and/or application resources can be dynamically instantiated based on service attributes and/or network capabilities. In one aspect, a customized and/or localized core slice can be selected that can deliver the requested service with target performance parameters. According to an aspect, dynamic selection, control, and/or management reporting can be provided for core network slices. Moreover, optimal core network slice selection can be performed to reduce network transport costs and efficiently deliver various services using an optimal core slice that matches a service profile being requested by an end user and/or device.

Abstract: A method for optimizing group communication services, the method comprising instantiating an adaptive homing tool as a virtual network function, the adaptive homing tool communicating with a centralized database in a multiple region telecommunications network; storing a user identification for plural group members in the database; when a service request is made by at least one group member that has moved outside of connectivity with a group home server, receiving group member location data for the plural group members in real time; assigning a group control application server to at least one group member when a group member initiates a service request; wherein the common service tool assigns the group application control server based on at least one of the priority data, group member location data, least network resources used, best path performance, shortest path performance, and quality of service.

Abstract: The present invention relates to the field of genetic engineering, particularly to a method for efficiently expressing pullulanase in Bacillus subtilis and recombinant Bacillus subtilis. said method includes steps of constructing modified Bacillus subtilis strain with deletion of alkaline protease gene and neutral protease gene, constructing expression vector including an optimized combination of promoter and signal peptide and pullulanase gene, and transforming said modified Bacillus subtilis strain with by said expression vector. A series of combinations of promoter and signal peptide are optimized to obtain the combination for efficiently expressing pululanase, provide an industrial application basis.

Abstract: Provided are crystalline form A of rebaudioside D, and a preparation method and application therefor. In X-ray powder diffraction analysis measured using Cu-K? rays and with 2? being expressed in degrees, crystalline form A of rebaudioside D has significant characteristic diffraction peaks at least at 4.53, 6.38, 12.76, 13.52, 17.48, 17.96, 20.07 and 22.63. The preparation method is a suspension method, a solvent evaporation method or a cooling method. The preparation method has a simple process, and is convenient to operate. A rebaudioside D crystalline form A product has a good degree of crystallinity, good water solubility, and high chemical stability.

Abstract: Network and/or application resources can be dynamically instantiated based on service attributes and/or network capabilities. In one aspect, a customized and/or localized core slice can be selected that can deliver the requested service with target performance parameters. According to an aspect, dynamic selection, control, and/or management reporting can be provided for core network slices. Moreover, optimal core network slice selection can be performed to reduce network transport costs and efficiently deliver various services using an optimal core slice that matches a service profile being requested by an end user and/or device.

Abstract: The present invention relates to the technical field of chemical drugs and crystal form processes, and to a pyrroloquinoline quinine B crystal form and a preparation method therefor. The present invention comprehensively characterizes the pyrroloquinoline quinine B crystal form by virtue of means such as X-ray powder diffraction analysis, thermo-gravimetric analysis, and differential scanning calorimetry analysis so as to find the fact that the pyrroloquinoline quinine B crystal form is high in crystallinity and low in hygroscopicity, and a regular crystal form can be formed, thereby facilitating process treatment and improvement of physical and chemical properties of a medicine, and improving the patent medicine performance. The preparation method for the pyrroloquinoline quinone B crystal form provided in the present invention is simple, easy to control, and high in reproducibility.

Abstract: The present invention relates to a stevioside M crystal form, a preparation method therefor and a use thereof, and specifically, relates to a naturally extracted high-intensity sweetener, i.e., a stevioside M crystal form A, the preparation method therefor and the user thereof. By means of comprehensive characterization of the new crystal form, the new crystal form is found to have advantages such as a high degree of crystallinity, good stability, and low hygroscopicity, and is applicable to a more comprehensive field of application. The preparation method in the present invention is simple and easy to operate, has high selectivity and good reproducibility, and can stably obtain the target crystal form.