Patents by Inventor Jianshe Kong

Jianshe Kong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF MAKING AND USING PDE9 INHIBITORS
    Publication number: 20230183244
    Abstract: The present invention relates to PDE9 inhibitors, their synthesis, and their use for treatment of benign prostate hyper-plasia, beta thalassemia, and sickle cell disease.
    Type: Application
    Filed: April 19, 2022
    Publication date: June 15, 2023
    Inventors: Niels SVENSTRUP, Jun ZHANG, Jikui SUN, Yuyin CHEN, Jianshe KONG, Rujian MA, Junhua ZHANG, Liang QIN, Huanming XIAO, Jinxu SUN, Xiao MENG, Fenglai SUN, Jingyang ZHU
  • Process for the synthesis of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one
    Patent number: 11370795
    Abstract: The present invention relates a process for the synthesis of 6-((3S,4S)-4-methyl-1-(pyrimidin-2 ylmethyl)pyrrolidin-3-yl)-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one, comprising use of the chiral acid (+)-O,O-Dibenzoyl-D-tartaic acid.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: June 28, 2022
    Assignee: Imara Inc.
    Inventors: Niels Svenstrup, Jun Zhang, Jikui Sun, Yuyin Chen, Jianshe Kong, Rujian Ma, Junhua Zhang, Liang Qin, Huanming Xiao, Jinxu Sun, Xiao Meng, Fenglai Sun, Jingyang Zhu
  • METHODS OF MAKING AND USING PDE9 INHIBITORS
    Publication number: 20200157108
    Abstract: The present invention relates to PDE9 inhibitors, their synthesis, and their use for treatment of benign prostate hyperplasia, beta thalassemia, and sickle cell disease.
    Type: Application
    Filed: May 25, 2018
    Publication date: May 21, 2020
    Inventors: Niels SVENSTRUP, Jun ZHANG, Jikui SUN, Yuyin CHEN, Jianshe KONG, Rujian MA, Junhua ZHANG, Liang QIN, Huanming XIAO, Jinxu SUN, Xiao MENG, Fenglai SUN, Jingyang ZHU
  • Enantio- and stereo specific synthesis of ?-amino-?-hydroxy amides
    Patent number: 8680294
    Abstract: Processes useful for the preparation of a Compound of Formula I: Formula (I). Intermediates useful for the preparation of the compound of Formula I, and processes useful for preparing said intermediates are disclosed.
    Type: Grant
    Filed: July 27, 2010
    Date of Patent: March 25, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: John Traverse, William M. Leong, Steven P. Miller, Jennifer Albaneze-Walker, Thomas J. Hunter, Lijun Wang, Hongbiao Liao, Ashok Arasappan, Scott T. Trzaska, Randi M. Smith, Azzeddine Lekhal, Stephane L. Bogen, Jianshe Kong, Frank Bennett, F. George Njoroge, Marc Poirier, Shen-Chun Kuo, Yonggang Chen, Kenneth S. Matthews, Patrice Demonchaux, Amadeo Ferreira
  • ENANTIO- AND STEREO-SPECIFIC SYNTHESES OF BETA-AMINO-ALPHA- HYDROXY AMIDES
    Publication number: 20120178942
    Abstract: Processes useful for the preparation of a Compound of Formula I: Formula (I). Intermediates useful for the preparation of the compound of Formula I, and processes useful for preparing said intermediates are disclosed.
    Type: Application
    Filed: July 27, 2010
    Publication date: July 12, 2012
    Inventors: John Traverse, William M. Leong, Steven P. Miller, Jennifer Albaneze-Walker, Thomas J. Hunter, Lijun Wang, Hongbiao Liao, Ashok Arasappan, Scott T. Trzaska, Randi M. Smith, Azzeddine Lekhal, Stephane L. Bogen, Jianshe Kong, Frank Bennett, F. George Njoroge, Marc Poirier, Shen-Chun Kuo, Yonggang Chen, Kenneth S. Matthews, Patrice Demonchaux, Amadeo Ferreira
  • Synthesis of 3-amino-4-substituted pyrazole derivatives
    Patent number: 7396929
    Abstract: This application discloses a novel process to synthesize 3-amino-4-substituted pyrazole derivatives, which may be used, for example, as intermediates to prepare compounds having, for example, pharmaceutical utility.
    Type: Grant
    Filed: June 7, 2006
    Date of Patent: July 8, 2008
    Assignee: Schering Corporation
    Inventors: Jianshe Kong, Tao Meng, Paul E. McNamara, Xian Liang, Jesse K. Wong
  • Synthesis of 3-amino-4-substituted pyrazole derivatives
    Publication number: 20060281756
    Abstract: This application discloses a novel process to synthesize 3-amino-4-substituted pyrazole derivatives, which may be used, for example, as intermediates to prepare compounds having, for example, pharmaceutical utility.
    Type: Application
    Filed: June 7, 2006
    Publication date: December 14, 2006
    Inventors: Jianshe Kong, Tao Meng, Paul McNamara, Xian Liang, Jesse Wong