Abstract: A 980 MPa-grade hot-rolled dual-phase steel and a manufacturing method therefor. The chemical components of the steel comprise, in percentage by weight, 0.10%-0.20% of C, 0.8%-2.0% of Si, 1.0%-2.0% of Mn, 0-0.02% of P, 0-0.005% of S, 0-0.003% of O, 0.02%-0.06% of Al, 0-0.006% of N, 0.01%-0.06% of Nb, 0.01%-0.05% of Ti, and the balance of Fe and inevitable impurities. In addition, the components need to meet the following relation: 0.05%?Nb+Ti?0.10. The microstructure of the steel is made of ferrite and martensite. The average grain size of the ferrite is 5-10 ?m, and the equivalent grain size of the martensite is 15-20 ?m.

Abstract: A 980 MPa-grade hot-rolled ferrite bainite dual-phase steel and a manufacturing method therefor. The chemical components of the steel comprise, in percentage by weight, 0.15-0.30% of C, 0.8-2.0% of Si, 1.0-2.0% of Mn, 0-0.02% of P, 0-0.005% of S, 0-0.003% of O, 0.5-1.0% of Al, 0-0.006% of N, 0.01-0.06% of Nb, 0.01-0.05% of Ti, and the balance of Fe and inevitable impurities. In addition, the chemical components meet the following relations: 0.05%?Nb+Ti?0.10%, and 2.5?Al/C?5.0. The microstructure of the steel is made of ferrite and bainite. The average grain size of the ferrite is 5-10 ?m, and the equivalent grain size of the bainite is less than or equal to 20 ?m. The yield strength of the steel is greater than or equal to 600 MPa, the tensile strength of the steel is greater than or equal to 980 Mpa, and the ductility is greater than or equal to 15%.

Abstract: A 980 MPa-grade hot-rolled dual-phase steel and a manufacturing method therefor. The chemical components of the steel comprise, in percentage by weight, 0.10%-0.20% of C, 0.8%-2.0% of Si, 1.0%-2.0% of Mn, 0-0.02% of P, 0-0.005% of S, 0-0.003% of O, 0.02%-0.06% of Al, 0-0.006% of N, 0.01%-0.06% of Nb, 0.01%-0.05% of Ti, and the balance of Fe and inevitable impurities. In addition, the components need to meet the following relation: 0.05%?Nb+Ti?0.10. The microstructure of the steel is made of ferrite and martensite. The average grain size of the ferrite is 5-10 ?m, and the equivalent grain size of the martensite is 15-20 ?m.

Abstract: A 980 MPa-grade hot-rolled ferrite bainite dual-phase steel and a manufacturing method therefor. The chemical components of the steel comprise, in percentage by weight, 0.15-0.30% of C, 0.8-2.0% of Si, 1.0-2.0% of Mn, 0-0.02% of P, 0-0.005% of S, 0-0.003% of O, 0.5-1.0% of Al, 0-0.006% of N, 0.01-0.06% of Nb, 0.01-0.05% of Ti, and the balance of Fe and inevitable impurities. In addition, the chemical components meet the following relations: 0.05%?Nb+Ti?0.10%, and 2.5?Al/C?5.0. The microstructure of the steel is made of ferrite and bainite. The average grain size of the ferrite is 5-10 ?m, and the equivalent grain size of the bainite is less than or equal to 20 ?m. The yield strength of the steel is greater than or equal to 600 MPa, the tensile strength of the steel is greater than or equal to 980 Mpa, and the ductility is greater than or equal to 15%.

Abstract: A 700 Mpa-level high-strength hot rolling Q&P steel and the method of manufacturing the same, which steel has the chemical compositions in weight percentage as follows: C: 0.15%˜0.40%; Si: 1.0%˜2.0%; Mn: 1.5%˜3.0%; P: less than or equal to 0.015%; S: less than or equal to 0.005%; Al: 0.3%˜1.0%; N: less than or equal to 0.006%; Ti: 0.005%˜0.015%, the remainders being Fe; it having a yield strength of more than or equal to 700 Mpa, a tensile strength of more than or equal to 1300 Mpa and an elongation rate of more than 10%.

Abstract: A 700 Mpa-level high-strength hot rolling Q&P steel and the method of manufacturing the same, which steel has the chemical compositions in weight percentage as follows: C: 0.15%˜0.40%; Si: 1.0%˜2.0%; Mn: 1.5%˜3.0%; P: less than or equal to 0.015%; S: less than or equal to 0.005%; Al: 0.3%˜1.0%; N: less than or equal to 0.006%; Ti: 0.005%˜0.015%, the remainders being Fe; it having a yield strength of more than or equal to 700 Mpa, a tensile strength of more than or equal to 1300 Mpa and an elongation rate of more than 10%.

Abstract: The present invention relates to the discovery that PDG2 is the nautral ligand for orphan receptor CRTH2, which interaction, it will now immediately be recognized, is important in the development of valuable pharmaceuticals. The present invention is therefore related to methods for screening for therapeutic compounds useful in the treatment of PGD2-related disorders such as allergy, asthma and inflammation. Appropriate assay methodology is also disclosed.

Abstract: A system has been constructed which is suitable for tetracycline-inducible gene expression in Gram-positive bacteria such as Staphylococcus aureus and Bacillus subtilis. The replicon/host gene expression system is tightly regulated, can be used in complex as well as minimal media, and can produce a high level of gene expression upon induction, with a variety of gene products. The gene expression system is suitable for production of products toxic to the host cells, and can be used, for example, for the analysis of gene expression and gene products in Gram-positive bacteria, and in a test of the effect of a peptide or polypeptide inhibitor of an S. aureus enzyme on the growth of S. aureus cells in culture or during infection of an animal.

Abstract: The invention comprises methods useful within a larger process for identifying compounds and/or designing further compounds with activity to produce a desired phenotype (for example, growth inhibition) in cells whose target cell component is the subject of certain studies to identify such compounds. The invention employs constructed cells comprising a regulable gene encoding a biomolecule which modulates (inhibits or activates) in vivo the function of a target component of the cell which can be an enzyme, for example, methionyl-tRNA synthetase of Staphylococcus aureus. The process incorporates methods for identifying biomolecules that bind to a chosen target cell component in vitro, methods for identifying biomolecules that also bind to the chosen target and modulate its function intracellularly, causing a phenotypic effect.

Abstract: A system has been constructed which is suitable for tetracycline-inducible gene expression in Gram-positive bacteria such as Staphylococcus aureus and Bacillus subtilis. The replicon/host gene expression system is tightly regulated, can be used in complex as well as minimal media, and can produce a high level of gene expression upon induction, with a variety of gene products. The gene expression system is suitable for production of products toxic to the host cells, and can be used, for example, for the analysis of gene expression and gene products in Gram-positive bacteria, and in a test of the effect of a peptide or polypeptide inhibitor of an S. aureus enzyme on the growth of S. aureus cells in culture or during infection of an animal.

Abstract: The present invention relates to the discovery that PDG2 is the nautral ligand for orphan receptor CRTH2, which interaction, it will now immediately be recognized, is important in the development of valuable pharmaceuticals. The present invention is therefore related to methods for screening for therapeutic compounds useful in the treatment of PGD2-related disorders such as allergy, asthma and inflammation. Appropriate assay methodology is also disclosed.

Abstract: Isolated and/or recombinant nucleic acids encoding mycobacterial seryl-tRNA synthetase have been characterized. Recombinant DNA constructs and vectors having a sequence which encodes mycobacterial seryl-tRNA synthetase have been made, and can be used for the construction of tester strains as well as for the production of isolated and/or recombinant seryl-tRNA synthetases. These enzymes or portions thereof are useful in the biochemical separation of serine and quantification of serine or ATP, and for producing antibodies useful in the purification and study of the enzyme, for example. Host cells and methods useful for producing recombinant mycobacterial seryl-tRNA synthetases are described, as are tester strains, which are cells engineered to rely on the function of the tRNA synthetase encoded by an introduced cloned gene.