Patents by Inventor Jianwei Che

Jianwei Che has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of mutant isocitrate dehydrogenases and compositions and methods thereof
    Patent number: 10781207
    Abstract: The invention provides novel chemical compounds useful for treating cancer, or a related disease or disorder thereof, and pharmaceutical composition and methods of preparation and use thereof.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: September 22, 2020
    Assignee: IsoCure Biosciences Inc.
    Inventors: Tinghu Zhang, Jianwei Che
  • INHIBITORS OF MUTANT ISOCITRATE DEHYDROGENASES AND COMPOSITIONS AND METHODS THEREOF
    Publication number: 20200140444
    Abstract: The invention provides novel chemical compounds useful for treating cancer, or a related disease or disorder thereof, and pharmaceutical composition and methods of preparation and use thereof.
    Type: Application
    Filed: July 24, 2018
    Publication date: May 7, 2020
    Inventors: Tinghu Zhang, Jianwei Che
  • INHIBITORS OF MUTANT ISOCITRATE DEHYDROGENASES AND COMPOSITIONS AND METHODS THEREOF
    Publication number: 20200071309
    Abstract: The invention provides novel chemical compounds useful for treating cancer, or a related disease or disorder thereof, and pharmaceutical composition and methods of preparation and use thereof.
    Type: Application
    Filed: December 18, 2017
    Publication date: March 5, 2020
    Inventors: Tinghu Zhang, Jianwei Che
  • Markers associated with Wnt inhibitors
    Patent number: 10422007
    Abstract: The invention provides methods of monitoring differential gene expression of biomarkers to determine patient sensitivity to Wnt inhibitor, methods of determining the sensitivity of a cell to an Wnt inhibitor by measuring biomarkers, methods of screening for candidate Wnt inhibitor, Wnt inhibitor for use in head and neck squamous cell carcinoma.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: September 24, 2019
    Assignee: Novartis AG
    Inventors: Jianwei Che, Jennifer Harris, Hsin-I Hsieh, Jie Li, Jun Liu, Nicholas Ng
  • INHIBITORS OF MUTANT ISOCITRATE DEHYDROGENASES AND COMPOSITIONS AND METHODS THEREOF
    Publication number: 20190233414
    Abstract: The invention provides novel chemical compounds useful for treating cancer, or a related disease or disorder thereof, and pharmaceutical composition and methods of preparation and use thereof.
    Type: Application
    Filed: October 10, 2017
    Publication date: August 1, 2019
    Inventors: Tinghu Zhang, Jianwei Che
  • MARKERS ASSOCIATED WITH WNT INHIBITORS
    Publication number: 20160024587
    Abstract: The invention provides methods of monitoring differential gene expression of biomarkers to determine patient sensitivity to Wnt inhibitor, methods of determining the sensitivity of a cell to an Wnt inhibitor by measuring biomarkers, methods of screening for candidate Wnt inhibitor, Wnt inhibitor for use in head and neck squamous cell carcinoma.
    Type: Application
    Filed: March 10, 2014
    Publication date: January 28, 2016
    Inventors: Jianwei CHE, Jennifer HARRIS, Hsin-I HSIEH, Jie LI, Jun LIU, Nicholas NG
  • Compounds and compositions as Syk kinase inhibitors
    Patent number: 8722692
    Abstract: Provided herein are a novel class of compounds of Formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: May 13, 2014
    Inventors: Jianwei Che, Qiang Ding, Xiaohui He, Hong Liu, Yahua Liu, Pierre-Yves Michellys, Barun Okram, Xu Wu, Kunyong Yang, Xuefeng Zhu
  • Compounds and compositions as kinase inhibitors
    Patent number: 8546370
    Abstract: The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT3, c-Kit, RET, TrkA, TrkB, TrkC-GR-1R, Alk, c-FMS, or combinations thereof.
    Type: Grant
    Filed: January 27, 2009
    Date of Patent: October 1, 2013
    Assignee: IRM LLC
    Inventors: Barun Okram, Tetsuo Uno, Qiang Ding, Yahua Liu, Yunho Jin, Qihui Jin, Xu Wu, Jianwei Che, S. Frank Yan, Xueshi Hao
  • Pyrido [4, 3-D] pyrimidinone derivatives as kinase inhibitors
    Patent number: 8354526
    Abstract: The invention provides a class of compounds of Formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT3, c-Kit, RET, TrkA, TrkB, TrkC, IGR-IR, AIk, c-FMS, or combinations thereof.
    Type: Grant
    Filed: January 27, 2009
    Date of Patent: January 15, 2013
    Assignee: IRM LLC
    Inventors: Qiang Ding, Yahua Liu, Xu Wu, Qihui Jin, Jianwei Che, S. Frank Yan
  • COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS
    Publication number: 20120184526
    Abstract: Provided herein are a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.
    Type: Application
    Filed: July 30, 2010
    Publication date: July 19, 2012
    Inventors: Jianwei Che, Qiang Ding, Xiaohui He, Hong Liu, Yahua Liu, Pierre-Yves Michellys, Barun Okram, Xu Wu, Kunyong Yang, Xuefeng Zhu
  • COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS
    Publication number: 20110053897
    Abstract: Provided herein area novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.
    Type: Application
    Filed: July 26, 2010
    Publication date: March 3, 2011
    Applicant: IRM LLC
    Inventors: Jianwei CHE, Bei Chen, Qiang Ding, Xueshi Hao, Xiaohui He, Songchun Jiang, Qihui Jin, Yunho Jin, Hong Liu, Yahua Liu, Barun Okram, Tetsuo Uno, Xu Wu, Kunyong Yang, Xuefeng Zhu
  • PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS
    Publication number: 20110003790
    Abstract: The invention provides a class of compounds of Formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT3, c-Kit, RET, TrkA, TrkB, TrkC, IGR-IR, AIk, c-FMS, or combinations thereof.
    Type: Application
    Filed: January 27, 2009
    Publication date: January 6, 2011
    Applicant: IRM LLC
    Inventors: Qiang Ding, Yahua Liu, Xu Wu, Qihui Jin, Jianwei Che, S. Frank Yan
  • COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS
    Publication number: 20110003798
    Abstract: The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat o prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT*, c-Kit, RET, TrkA, TrkB, TrkC-GR-1R, Alk, c-FMS or combinations thereof.
    Type: Application
    Filed: January 27, 2009
    Publication date: January 6, 2011
    Applicant: IRM LLC
    Inventors: Barun Okram, Tetsuo Uno, Qiang Ding, Yahua Liu, Yunho Jin, Qihui Jin, Xu Wu, Jianwei Che, S. Frank Yan, Xueshi Hao
  • Method and system for clustering and rescaling for molecular analysis
    Publication number: 20050214788
    Abstract: Methods and/or systems for modeling molecular systems and/or other physical systems using scaling optimization.
    Type: Application
    Filed: September 9, 2004
    Publication date: September 29, 2005
    Applicant: IRM, LLC
    Inventor: Jianwei Che