Patents by Inventor Jianwen Wei

Jianwen Wei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Short chain neurotoxin from sea snake-and genes encoding the neurotoxin
    Patent number: 7294697
    Abstract: In this invention, three genes encoding short chain neurotoxin are obtained by sea snake—Lapemis hardwickii venom gland cDNA library construction and DNA sequencing, named sn12, sn36, and sn160, respectively. The three genes are modified and amplified by PCR method, then cloned into expression vector PETTRX. The three neurotoxin genes are all highly expressed in soluble fusion protein in E. coli stain BL21-DE3 which is used as a expression host when induced with IPTG. Studies on the analgesic effects of the three recombinant short chain neurotoxins showed that three proteins, SN12, SN36 and SN160 all can significantly increase the pain threshold value of mouse.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: November 13, 2007
    Assignee: Zhongshan University
    Inventors: Anlong Xu, Xiaofen Zhong, Lisheng Peng, Jianwen Wei, Wenyan Wu, Wenli Yang
  • Short chain neurotoxin from sea snake-lapemis hardwickii and genes encoding the neurotoxin
    Publication number: 20050232913
    Abstract: In this invention, three genes encoding short chain neurotoxin are obtained by sea snake—Lapemis hardwickii venom gland cDNA library construction and DNA sequencing, named sn12, sn36, and sn160, respenctively. The three genes are modified and amplified by PCR method, then cloned into expression vector PETTRX. The three neurotoxin genes are all highly expressed in soluble fusion protein in E. coli stain BL21-DE3 which is used as a expression host when induced with IPTG. Studies on the analgesic effects of the three recombinant short chain neurotoxins showed that three proteins, SN12, SN36 and SN160 all can significantly increase the pain threshold value of mouse.
    Type: Application
    Filed: September 14, 2001
    Publication date: October 20, 2005
    Inventors: Anlong Xu, Xiaofen Zhong, Lisheng Peng, Jianwen Wei, Wenyan Wu, Wenli Yang