Abstract: The present invention discloses a nucleic acid molecule for encoding a chimeric antigen receptor targeting CD22 and CD19. The chimeric antigen receptor of the present invention can be used for treatment of CD19+ and CD22+ B-cell hematological tumors, as well as combined treatment with CD19 CAR-T cells or CD22 CAR-T cells.

Abstract: A chimeric antigen receptor, comprising an amino acid sequence shown in SEQ ID NO. 1. A nucleic acid encoding the chimeric antigen receptor, a vector comprising the nucleic acid, an immune effector cell comprising the chimeric antigen receptor, the nucleic acid molecule and/or the vector, a method for preparing the immune effector cell, a composition comprising the immune effector cell, and use of the chimeric antigen receptor.

Abstract: A chimeric antigen receptor, comprising an amino acid sequence shown in SEQ ID NO. 1. A nucleic acid encoding the chimeric antigen receptor, a vector comprising the nucleic acid, an immune effector cell comprising the chimeric antigen receptor, the nucleic acid molecule and/or the vector, a method for preparing the immune effector cell, a composition comprising the immune effector cell, and use of the chimeric antigen receptor.

Abstract: A method for arterial endothelial-enhanced functional T cell generation is provided. In the method, arterial endothelial cells enhance functional T cell generation by promoting the generation of hematopoietic progenitor cells with T-lineage bias. The first stage of T cell differentiation from human pluripotent stem cells (hPSCs) is optimized, and it is found that hPSC-derived autologous arterial endothelial cells increase the T cell potential of hematopoietic progenitor cells. Moreover, the T cells generated by arterial endothelial cell priming share similar function to that of human peripheral blood T cells. hPSC-derived CD19-CAR-T cells have been verified to have tumor-killing effects both in vivo and in vitro. The established hPSC-T differentiation system would provide a valuable resource for chimeric antigen receptor T cell (CAR-T) therapy.

Abstract: Embodiments of the present disclosure relate to a method and apparatus for controlling mouth shape changes of a three-dimensional virtual portrait, relating to the field of cloud computing. The method may include: acquiring a to-be-played speech; sliding a preset time window at a preset step length in the to-be-played speech to obtain at least one speech segment; generating, based on the at least one speech segment, a mouth shape control parameter sequence for the to-be-played speech; and controlling, in response to playing the to-be-played speech, a preset mouth shape of the three-dimensional virtual portrait to change based on the mouth shape control parameter sequence.

Abstract: A chimeric antigen receptor, comprising an amino acid sequence shown in SEQ ID NO. 1. A nucleic acid encoding the chimeric antigen receptor, a vector comprising the nucleic acid, an immune effector cell comprising the chimeric antigen receptor, the nucleic acid molecule and/or the vector, a method for preparing the immune effector cell, a composition comprising the immune effector cell, and use of the chimeric antigen receptor.

Abstract: Embodiments of the present disclosure provide a method and apparatus for processing information. A method may include: generating voice response information based on voice information sent by a user; generating a phoneme sequence based on the voice response information; generating mouth movement information based on the phoneme sequence, the mouth movement information being used for controlling a mouth movement of a displayed three-dimensional human image when playing the voice response information; and playing the voice response information, and controlling the mouth movement of the three-dimensional human image based on the mouth movement information.

Abstract: Embodiments of the present disclosure provide a method and apparatus for generating information, and relate to the field of cloud computation. The method may include: receiving a video and an audio of a user from a client; analyzing the video and the audio to determine an intention category of the user; generating feedback information according to the intention category of the user and a preset service information set; generating a video of a pre-established three-dimensional virtual portrait by means of an animation engine based on the feedback information; and transmitting the video of the three-dimensional virtual portrait to the client, for the client to present to the user.

Abstract: Embodiments of the present disclosure provide a method and apparatus for generating an animation. A method may include: extracting an audio feature from target speech segment by segment, to aggregate the audio feature into an audio feature sequence composed of an audio feature of each speech segment; inputting the audio feature sequence into a pre-trained mouth-shape information prediction model, to obtain a mouth-shape information sequence corresponding to the audio feature sequence; generating, for mouth-shape information in the mouth-shape information sequence, a face image including a mouth-shape object indicated by the mouth-shape information; and using the generated face image as a key frame of a facial animation, to generate the facial animation.

Abstract: Embodiments of the present disclosure relate to a method and apparatus for controlling mouth shape changes of a three-dimensional virtual portrait, relating to the field of cloud computing. The method may include: acquiring a to-be-played speech; sliding a preset time window at a preset step length in the to-be-played speech to obtain at least one speech segment; generating, based on the at least one speech segment, a mouth shape control parameter sequence for the to-be-played speech; and controlling, in response to playing the to-be-played speech, a preset mouth shape of the three-dimensional virtual portrait to change based on the mouth shape control parameter sequence.

Abstract: Embodiments of the present disclosure provide a method and apparatus for generating information, and relate to the field of cloud computation. The method may include: receiving a video and an audio of a user from a client; analyzing the video and the audio to determine an intention category of the user; generating feedback information according to the intention category of the user and a preset service information set; generating a video of a pre-established three-dimensional virtual portrait by means of an animation engine based on the feedback information; and transmitting the video of the three-dimensional virtual portrait to the client, for the client to present to the user.

Abstract: Embodiments of the present disclosure provide a method and apparatus for processing information. A method may include: generating voice response information based on voice information sent by a user; generating a phoneme sequence based on the voice response information; generating mouth movement information based on the phoneme sequence, the mouth movement information being used for controlling a mouth movement of a displayed three-dimensional human image when playing the voice response information; and playing the voice response information, and controlling the mouth movement of the three-dimensional human image based on the mouth movement information.

Abstract: Embodiments of the present disclosure provide a method and apparatus for generating an animation. A method may include: extracting an audio feature from target speech segment by segment, to aggregate the audio feature into an audio feature sequence composed of an audio feature of each speech segment; inputting the audio feature sequence into a pre-trained mouth-shape information prediction model, to obtain a mouth-shape information sequence corresponding to the audio feature sequence; generating, for mouth-shape information in the mouth-shape information sequence, a face image including a mouth-shape object indicated by the mouth-shape information; and using the generated face image as a key frame of a facial animation, to generate the facial animation.

Abstract: A method and device for acquiring a response message, a method and device for routing the response message, and a system for acquiring the response message and routing the response message are disclosed. The method includes steps that: a source node sends a service request message to a second group of nodes via a first group of DRA nodes; and the source node acquires the service response message returned by the destination node via the second group of DRA nodes.

Abstract: A method and device for acquiring a response message, a method and device for routing the response message, and a system for acquiring the response message and routing the response message are disclosed. The method includes steps that: a source node sends a service request message to a second group of nodes via a first group of DRA nodes; and the source node acquires the service response message returned by the destination node via the second group of DRA nodes.

Abstract: The present invention relates to the discovery of the human nuclear receptor co-repressor gene and the human nuclear receptor co-repressor protein, a molecule that recruits a complex of proteins that alters chromatin structure and mediates transcriptional repression. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed.