Patents by Inventor Jianxin Shi

Jianxin Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PRODUCING NATURAL KILLER CELLS FROM PLURIPOTENT STEM CELLS
    Publication number: 20240108656
    Abstract: The present disclosure provides, among other things, a method for efficiently producing a cell population enriched in Natural Killer cells (NK cells) from induced pluripotent cells.
    Type: Application
    Filed: December 14, 2023
    Publication date: April 4, 2024
    Inventors: Lan Cao, Hui-Hsin Chang, Jianxin Hu, Yu Qian, Xi Shi
  • TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF
    Publication number: 20240092744
    Abstract: A tricyclic compound having the structure represented by general formula (I), a pharmaceutical composition thereof, a preparation method therefor and the use thereof in the prevention and treatment of a variety of diseases caused by toxic aldehydes.
    Type: Application
    Filed: December 27, 2021
    Publication date: March 21, 2024
    Inventors: Huijun Yin, Xu Yan, Guobiao Liu, Jianxin Shi, Shizhu Chen
  • TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF
    Publication number: 20230021669
    Abstract: Disclosed are a tricyclic compound as represented by general formula (I), a pharmaceutical composition containing same, and a preparation method therefor and the medical use thereof. The compound can be used for preventing and treating a variety of diseases caused by toxic aldehydes.
    Type: Application
    Filed: December 29, 2020
    Publication date: January 26, 2023
    Applicant: The National Institutes of Pharmaceutical R&D Co., Ltd.
    Inventors: Huijun YIN, Xu YAN, Guobiao LIU, Jianxin SHI, Shizhu CHEN, Siyang REN, Yadong FENG
  • AROMATIC RING OR HETEROAROMATIC RING COMPOUNDS, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF
    Publication number: 20220127258
    Abstract: The present invention relates to aromatic ring or heteroaromatic ring compounds, a preparation method therefor and a medical use thereof. Particularly, the present invention relates to a compound as shown in general formula (I) and a preparation method therefor, a pharmaceutical composition comprising the compound and a use thereof as an agonist for a farnesoid X receptor (FXR). The compound and the pharmaceutical composition comprising the compound can be used for treating and/or preventing FXR activity-related diseases, for example, cholestatic symptoms, diabetes and complications thereof, nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatosis heptitis (NASH), obesity or metabolic syndrome (diseases associated with dyslipidemia, diabetes, abnormally high body weight index), cardiovascular diseases and so on. The definition of each substituent in the general formula (I) is the same as that in the description.
    Type: Application
    Filed: January 17, 2020
    Publication date: April 28, 2022
    Inventors: Huijun YIN, Xu YAN, Libin ZONG, Jianxin SHI, Chunyan LIU, Shouliang ZHANG, Jiawei LU, Hao LI
  • Ligand sensing fluorescent acetylcholinesterase for detection of organophosphate activity
    Patent number: 8642273
    Abstract: Disclosed are methods for the preparation and use of labeled AChE and labeled AChE inhibitory conjugate compositions for detecting accumulation of toxic materials such as organophosphates, insecticides, and other nerve agents. Also disclosed are methods for the use of labeled AChE and labeled AChE inhibitory conjugate compositions in a variety of areas, including the detecting of toxic materials in biological samples, in the area of food and water analysis, in environmental monitoring, and in industrial settings.
    Type: Grant
    Filed: April 16, 2003
    Date of Patent: February 4, 2014
    Assignee: The Regents of the University of California
    Inventors: Palmer Taylor, Zoran Radic, Jianxin Shi, Aileen Boyd