Patents by Inventor Jianxiu Liu

Jianxiu Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing macrocyclic compounds
    Patent number: 8222369
    Abstract: Disclosed is a process for preparing a macrocyclic compound of the formula (I) wherein a hydroxyl-substituted macrocyclic compound of formula (3) is reacted with a sulfonyl-substituted compound of formula QUIN: The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: July 17, 2012
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Carl Alan Busacca, Fabrice Gallou, Nizar Haddad, Azad Hossain, Suresh R. Kapadia, Jianxiu Liu, Chris H. Senanayake, Xudong Wei, Nathan K. Yee
  • Process for making heteroaryl amine intermediate compounds
    Patent number: 7714127
    Abstract: Disclosed are processes to produce a compound of the formula (I):
    Type: Grant
    Filed: October 4, 2006
    Date of Patent: May 11, 2010
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Guisheng Li, Jianxiu Liu, Zhi-Hui (Bruce) Lu, Ming Shen, Sonia Rodriguez, Vittorio Farina
  • PROCESS FOR PREPARING MACROCYCLIC COMPOUNDS
    Publication number: 20090326194
    Abstract: Disclosed is a process for preparing a macrocyclic compound of the formula (I) wherein a hydroxyl-substituted macrocyclic compound of formula (3) is reacted with a sulfonyl-substituted compound of formula QUIN: The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
    Type: Application
    Filed: September 2, 2009
    Publication date: December 31, 2009
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Carl Alan BUSACCA, Fabrice GALLOU, Nizar HADDAD, Azad HOSSAIN, Suresh R. KAPADIA, Jianxiu LIU, Chris SENANAYAKE, Xudong WEI, Nathan K. YEE
  • Process for preparing macrocyclic compounds
    Patent number: 7608614
    Abstract: Intermediates of the formula QUIN: and methods for their preparation are described. The intermediate compounds are useful for preparing active agents for the treatment of hepatitis C virus (HCV) infection.
    Type: Grant
    Filed: March 6, 2006
    Date of Patent: October 27, 2009
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Carl Alan Busacca, Fabrice Gallou, Nizar Haddad, Azad Hossain, Suresh R. Kapadia, Jianxiu Liu, Chris Senanayake, Xudong Wei, Nathan K. Yee
  • 2-Bromoanaline and 2-chloroaniline compounds
    Patent number: 7408076
    Abstract: Disclosed are 2-bromoaniline or 2-chloroaniline compounds of formula (I): wherein R, R1 and X are as defined. The compounds are useful as intermediates for preparing indole compounds.
    Type: Grant
    Filed: August 29, 2006
    Date of Patent: August 5, 2008
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Guisheng Li, Jianxiu Liu, Zhi-Hui Lu, Frank Roschangar, Chris Hugh Senanayake, Ming Shen
  • Process for Making Heteroaryl Amine Intermediate Compounds
    Publication number: 20070105857
    Abstract: Disclosed are processes to produce a compound of the formula (I):
    Type: Application
    Filed: October 4, 2006
    Publication date: May 10, 2007
    Inventors: Guisheng Li, Jianxiu Liu, Zhi-Hui (Bruce) Lu, Ming Shen, Sonia Rodriguez, Vittorio Farina
  • Palladium catalyzed indolization of 2-bromo or chloroanilines
    Publication number: 20060287376
    Abstract: The present invention provides indole compounds of general formula III comprising the compounds of formula (III); wherein R, and R1-3 a defined herein.
    Type: Application
    Filed: August 29, 2006
    Publication date: December 21, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Guisheng LI, Jianxiu Liu, Zhi-Hui Lu, Frank Roschangar, Chris Senanayake, Ming Shen
  • Palladium catalyzed indolization of 2-bromo or chloroanilines
    Patent number: 7126009
    Abstract: The present invention provides a method for making substituted indole compounds of general formula III comprising the step of: (a) reacting a 2-bromoaniline or 2-chloroaniline of general formula (I) (I) wherein: X, R and R1 are defined herein with a substituted acetylene of formula (II) wherein R2 and R3 are defined herein in the presence of a palladium catalyst, a ligand, and a base in a solvent at a suitable temperature to give a compound of formula (III);
    Type: Grant
    Filed: March 14, 2005
    Date of Patent: October 24, 2006
    Assignee: Boehringer Ingelheim International, GmbH
    Inventors: Guisheng Li, Jianxiu Liu, Zhi-Hui Lu, Frank Roschangar, Chris Hugh Senanayake, Ming Shen
  • PROCESS FOR PREPARING MACROCYCLIC COMPOUNDS
    Publication number: 20060205638
    Abstract: Disclosed is a process for preparing a macrocyclic compound of the formula (I) wherein a hydroxyl-substituted macrocyclic compound of formula (3) is reacted with a sulfonyl-substituted compound of formula QUIN: The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
    Type: Application
    Filed: March 6, 2006
    Publication date: September 14, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Carl Busacca, Fabrice Gallou, Nizar Haddad, Azad Hossain, Suresh Kapadia, Jianxiu Liu, Chris Senanayake, Xudong Wei, Nathan Yee
  • Palladium catalyzed indolization of 2-bromo or chloroanilines
    Publication number: 20050209465
    Abstract: The present invention provides a method for making substituted indole compounds of general formula III comprising the step of: (a) reacting a 2-bromoaniline or 2-chloroaniline of general formula (I) (I) wherein: X, R and R1 are defined herein with a substituted acetylene of formula (II) wherein R2 and R3 in the presence of a palladium catalyst, a ligand, and a base in a solvent at a suitable temperature to give a compound of formula (III);
    Type: Application
    Filed: March 14, 2005
    Publication date: September 22, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Guisheng Li, Jianxiu Liu, Zhi-Hui Lu, Frank Roschangar, Chris Senanayake, Ming Shen