Abstract: A dishwasher water channel, which is integrated in a base of a dishwasher, is disclosed. The dishwasher water channel has a water distribution chamber, a flow guidance channel, and a spray arm. The flow guidance channel has one end communicating with the water distribution chamber and the other end communicating with the spray arm. The flow guidance channel extends from an outer wall of the water distribution chamber toward a rear end of the base and communicates with the spray arm at the rear end of the base. A spray arm seat is provided between the spray arm and the flow guidance channel and penetrates the base. The spray arm is connected to a top of the spray arm seat and located above the base to spray water out of the spray arm seat, and the flow guidance channel is connected to a bottom of the spray arm seat and located below the base.

Abstract: Disclosed is a binding protein having at least two protein functional regions, the binding protein comprising a protein functional region A and a protein functional region B; the protein functional region A and the protein functional region B target different antigens or epitopes, the protein functional region A is a Fab or a scFv structure, the protein functional region B is a VH structure, and there are one or more of each of the protein functional region A and the protein functional region B. A multi-specific binding protein has a smaller molecular weight, fewer polypeptide chains, and a simpler structure. By means of different structure types, relative positions, binding valence and other parameters, the functional activities for different targets can be adjusted, and then different combinations of activities can be designed so as to meet the needs of different dose combinations of clinical combinations.

Abstract: The present invention discloses a 4-1BB-binding protein and use thereof. The 4-1BB-binding protein comprises a heavy chain variable region, wherein the heavy chain variable region comprises HCDR1, HCDR2 and HCDR3, wherein the HCDR1 comprises a sequence as set forth in SEQ ID NO: 15 or a variant 1 thereof, or SEQ ID NO: 16; the HCDR2 comprises a sequence selected from SEQ ID NO: 60 or a variant 2 thereof, and SEQ ID NO: 50 or a variant 4 thereof; the HCDR3 comprises a sequence as set forth in SEQ ID NO: 103 or a variant 3 thereof, SEQ ID NO: 333 or a variant 5 thereof, SEQ ID NO: 110, SEQ ID NO: 111, SEQ ID NO: 116, SEQ ID NO: 326, SEQ ID NO: 331, SEQ ID NO: 334 or SEQ ID NO: 96. The 4-1BB-binding protein of the present invention is a fully human antibody having the binding activity to human 4-1BB and cynomolgus monkey 4-1BB. Some 4-1BB-binding proteins are only half the size of conventional IgG antibodies; they can be well used for bispecific antibodies.

Abstract: Provided are a bispecific antibody and use thereof. The bispecific antibody comprises a B7-H4-targeting antigen-binding domain and a 4-1BB-targeting antigen-binding domain. The bispecific antibody has one or two or three sites for binding to 4-1BB, along with a novel fully human B7-H4 antibody. The bispecific antibody specifically binds to tumor cells by targeting B7-H4, reducing toxicity induced by 4-1BB activation. In addition, the bispecific antibody of the present invention comprises a human Fc fragment, and thus retains the binding of Fc to FcRn and has a longer half-life.

Abstract: A dishwasher is provided. The dishwasher has an inner container, a frame and a door body. The an inner container has an accommodation cavity. The accommodation cavity has an forward-facing opening. The frame is connected to an outer surface of the inner container and extends along an edge of the opening of the accommodation cavity. A sealing groove is defined in the frame. Alternatively, the sealing groove is defined by enclosing the frame and the edge of the opening of the inner container. A sealing strip is disposed in the sealing groove. A door body is configured to open or close the opening of the accommodation cavity. The door body abuts against the sealing strip in response to the opening of the accommodation cavity being covered by the door body.

Abstract: A connection structure used with a dishwasher is provided. The connection structure has a base, an outer plate located at an outside of the base at an interval, and a top support mechanism connected to the outside of the base. The top support mechanism has one or more top support tubes sequentially stacked in a direction from the base to the outer plate. Each top support tube has first, second, third, and fourth top support plates, each having elastic recovery property. An opening direction of a first spacing groove formed by the first and second support plates and an opening direction of a second spacing groove formed by the third and fourth support plates are opposite to each other.

Abstract: A dishwasher water channel, which is integrated in a base of a dishwasher, is disclosed. The dishwasher water channel has a water distribution chamber, a flow guidance channel, and a spray arm. The flow guidance channel has one end communicating with the water distribution chamber and the other end communicating with the spray arm. The flow guidance channel extends from an outer wall of the water distribution chamber toward a rear end of the base and communicates with the spray arm at the rear end of the base. A spray arm seat is provided between the spray arm and the flow guidance channel and penetrates the base. The spray arm is connected to a top of the spray arm seat and located above the base to spray water out of the spray arm seat, and the flow guidance channel is connected to a bottom of the spray arm seat and located below the base.

Abstract: A dishwasher and a base component, the base component includes base (1) and overflow cover (2). The overflow cover (2) includes an overflow port (211) and an overflow water distribution cover body (21) of an mounting portion (2131), the overflow water distribution cover body (21) has an overflow chamber (212), and the base (1) has an overflow hole (112) and a connection portion (113) which is docked with the mounting portion (2131). Both the overflow port (211) and the overflow hole (112) communicate with the overflow chamber (212) and form an overflow channel (214); the water inlet plate (215) is provided on the overflow cover (2) adjacent to the upper surface (10) of the base (1) and communicates with the overflow port (211). The water inlet plate (215) is provided with a plurality of filter holes (2151).

Abstract: Provided are an antibody targeting BCMA, a bispecific antibody targeting BCMA and CD3, and applications thereof. The antibody targeting BCMA comprises two heavy chain variable regions, the heavy chain variable regions comprising HCDR1, HCDR2, and HCDR3 as shown in the amino acid sequences of SEQ ID NO: 22, SEQ ID NO: 33 and SEQ ID NO: 42, or HCDR1, HCDR2, and HCDR3 as shown in the amino acid sequences of SEQ ID NO: 26, SEQ ID NO: 37 and SEQ ID NO: 41. The antibody effectively targets human BCMA and binds to cynomolgus BCMA; the bispecific antibody effectively targets both human BCMA and human CD3, and can bind to cynomolgus BCMA and cynomolgus CD3.

Abstract: A dishwasher and a base component, the base component includes base (1) and overflow cover (2). The overflow cover (2) includes an overflow port (211) and an overflow water distribution cover body (21) of an mounting portion (2131), the overflow water distribution cover body (21) has an overflow chamber (212), and the base (1) has an overflow hole (112) and a connection portion (113) which is docked with the mounting portion (2131). Both the overflow port (211) and the overflow hole (112) communicate with the overflow chamber (212) and form an overflow channel (214); the water inlet plate (215) is provided on the overflow cover (2) adjacent to the upper surface (10) of the base (1) and communicates with the overflow port (211). The water inlet plate (215) is provided with a plurality of filter holes (2151).