Patents by Inventor Jianyan Wang

Jianyan Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Arginase inhibitors and methods of use thereof
    Patent number: 12195485
    Abstract: Disclosed are compounds of formula (Ia) or a pharmaceutically acceptable salt thereof pharmaceutical compositions comprising compounds of formula (Ia) and methods of using the same for treating cancer or a respiratory inflammatory disease and inhibiting arginase: wherein R1 is —NHR1a; R1a is —H or —C(O)CH(R1b)NHR1c; and R1b is selected from —H, —(C1-C4) alkyl and CH2OR1d and R1c is —H; or R1b and R1c, together with the atom to which they are attached, form a 5-membered heterocyclic ring; and R1d is H or —CH3.
    Type: Grant
    Filed: July 15, 2022
    Date of Patent: January 14, 2025
    Assignee: AstraZeneca AB
    Inventors: Scott Nathan Mlynarski, Tyler Grebe, Sameer Kawatkar, Maurice Raymond Verschoyle Finlay, Iain Simpson, Jianyan Wang, Steve Cook, Dedong Wu
  • Arginase inhibitors and methods of use thereof
    Patent number: 11912727
    Abstract: Disclosed are compounds of formula (Ia) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of formula (Ia) and methods of using the same for treating cancer or a respiratory inflammatory disease and inhibiting arginase: wherein R1 is —NHR1a; R1a is —H or —C(O)CH(R1b)NHR1c; and R1b is selected from —H, —(C1-C4) alkyl and CH2OR1d and R1c is —H; or R1b and R1c, together with the atom to which they are attached, form a 5-membered heterocyclic ring; and R1d is H or —CH3.
    Type: Grant
    Filed: July 10, 2023
    Date of Patent: February 27, 2024
    Assignee: AstraZeneca AB
    Inventors: Scott Nathan Mlynarski, Tyler Grebe, Sameer Kawatkar, Maurice Raymond Verschoyle Finlay, Iain Simpson, Jianyan Wang, Steve Cook, Dedong Wu
  • Arginase Inhibitors and Methods of Use Thereof
    Publication number: 20230365599
    Abstract: Disclosed are compounds of formula (Ia) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of formula (Ia) and methods of using the same for treating cancer or a respiratory inflammatory disease and inhibiting arginase: wherein R1 is —NHR1a; R1a is —H or —C(O)CH(R1b)NHR1c; and R1b is selected from —H, —(C1-C4) alkyl and CH2OR1d and R1c is —H; or R1b and R1c, together with the atom to which they are attached, form a 5-membered heterocyclic ring; and R1d is H or —CH3.
    Type: Application
    Filed: July 10, 2023
    Publication date: November 16, 2023
    Inventors: Scott Nathan MLYNARSKI, Tyler GREBE, Sameer KAWATKAR, Maurice Raymond Verschoyle FINLAY, Iain SIMPSON, Jianyan WANG, Steve COOK, Dedong WU
  • Arginase Inhibitors and Methods of Use Thereof
    Publication number: 20230122859
    Abstract: Disclosed are compounds of formula (Ia) or a pharmaceutically acceptable salt thereof pharmaceutical compositions comprising compounds of formula (Ia) and methods of using the same for treating cancer or a respiratory inflammatory disease and inhibiting arginase: wherein R1 is —NHR1a; R1a is —H or —C(O)CH(R1b)NHR1c; and R1b is selected from —H, —(C1-C4) alkyl and CH2OR1d and R1c is —H; or R1b and R1c, together with the atom to which they are attached, form a 5-membered heterocyclic ring; and R1d is H or —CH3.
    Type: Application
    Filed: July 15, 2022
    Publication date: April 20, 2023
    Inventors: Scott Nathan MLYNARSKI, Tyler GREBE, Sameer KAWATKAR, Maurice Raymond Verschoyle FINLAY, Iain SIMPSON, Jianyan WANG, Steve COOK, Dedong WU
  • Arginase inhibitors and methods of use thereof
    Patent number: 11420984
    Abstract: Disclosed are compounds of formula (Ia) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of formula (Ia) and methods of using the same for treating cancer or a respiratory inflammatory disease and inhibiting arginase: wherein R1 is —NHR1a; R1a is —H or —C(O)CH(R1b)NHR1c; R1b is selected from —H, —(C1-C4) alkyl and CH2OR1d; R1c is —H; or R1b and R1c, together with the atom to which they are attached, form a 5-membered heterocyclic ring; and R1d is H or —CH3.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: August 23, 2022
    Assignee: AstraZeneca AB
    Inventors: Scott Nathan Mlynarski, Tyler Grebe, Sameer Kawatkar, Maurice Raymond Verschoyle Finlay, Iain Simpson, Jianyan Wang, Steve Cook, Dedong Wu
  • Arginase Inhibitors and Methods of Use Thereof
    Publication number: 20210002305
    Abstract: Disclosed are compounds of formula (Ia) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of formula (Ia) and methods of using the same for treating cancer or a respiratory inflammatory disease and inhibiting arginase: wherein R1 is —NHR1a; R1a is —H or —C(O)CH(R1b)NHR1c; R1b is selected from —H, —(C1-C4) alkyl and CH2OR1d; R1c is —H; or R1b and R1c, together with the atom to which they are attached, form a 5-membered heterocyclic ring; and R1d is H or —CH3.
    Type: Application
    Filed: February 15, 2019
    Publication date: January 7, 2021
    Inventors: Scott Nathan MLYNARSKI, Tyler GREBE, Sameer KAWATKAR, Maurice Raymond Verschoyle FINLAY, Iain SIMPSON, Jianyan WANG, Steve COOK, Dedong WU
  • PROCESS FOR MAKING CAMPTOTHECIN DERIVATIVES
    Publication number: 20060094876
    Abstract: A process for synthesizing highly lipophilic derivatives of camptothecin. The process includes reacting dissolved, underivatized camptothecin with a silylated heterocyclic compound in a modified Minisci-type alkylation reaction to produce 7-substituted derivatives of camptothecin.
    Type: Application
    Filed: October 28, 2004
    Publication date: May 4, 2006
    Inventors: Ye Wu, Kesavaram Narkunan, Jianyan Wang, Harry Kochat
  • Pharmaceutical formulations of camptothecins and process for making same
    Publication number: 20060094692
    Abstract: This invention relates to pharmaceutically elegant formulations of highly lipophilic camptothecin derivatives.
    Type: Application
    Filed: October 28, 2004
    Publication date: May 4, 2006
    Inventors: Frederick Hausheer, Jianyan Wang, Harry Kochat
  • Process for making camptothecin derivatives
    Patent number: 7030243
    Abstract: A process for synthesizing highly lipophilic derivatives of camptothecin. The process includes reacting dissolved, underivatized camptothecin with a silylated heterocyclic compound in a modified Minisci-type alkylation reaction to produce 7-substituted derivatives of camptothecin.
    Type: Grant
    Filed: October 28, 2004
    Date of Patent: April 18, 2006
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Ye Wu, Kesavaram Narkunan, Jianyan Wang, Harry Kochat
  • Process for synthesizing L-?-methylene glutamic acid and analogs
    Patent number: 6977311
    Abstract: A process for synthesizing substantially enantiomerically pure L-amino acids, particularly L-?-methylene glutamic acid, and esters and salts thereof. The process includes the derivatization of (2S)-pyroglutamic acid, and the decyclization of the resulting derivative to form the desired end product.
    Type: Grant
    Filed: July 25, 2003
    Date of Patent: December 20, 2005
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Harry Kochat, Xinghai Chen, Ye Wu, Qiuli Huang, Jianyan Wang, Vincent Gerusz
  • Process for synthesizing L--methylene glutamic acid and analogs
    Publication number: 20040106826
    Abstract: A process for synthesizing substantially enantiomerically pure L-amino acids, particularly L- -methylene glutamic acid, and esters and salts thereof. The process includes the derivatization of (2S)-pyroglutamic acid, and the decyclization of the resulting derivative to form the desired end product.
    Type: Application
    Filed: July 25, 2003
    Publication date: June 3, 2004
    Inventors: Harry Kochat, Xinghai Chen, Ye Wu, Qiuli Huang, Jianyan Wang, Vincent Gerusz