Abstract: This invention relates to compositions comprising co-crystals of (?)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (?)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.

Abstract: The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.

Abstract: This invention relates to relates to methods for producing gossypol acetic acid co-crystals and (?)-gossypol acetic acid co-crystals. The invention also relates to pharmaceutical compositions comprising gossypol acetic acid co-crystals and (?)-gossypol acetic acid co-crystals and the use of gossypol acetic acid co-crystals and (?)-gossypol acetic acid co-crystals for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.

Abstract: The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of XIAP family proteins. In particular, the present invention provides embelin and other XIAP inhibitors and methods of using these compounds as antagonists of the anti-apoptotic effects of XIAP family member proteins. The present invention also provides methods for treating diseases and pathologies (e.g., neoplastic diseases).

Abstract: The present invention discloses a digital signature scheme based on braid group conjugacy problem and a verifying method thereof, wherein the signatory S selects three braids x?LBm(l), x??Bn(l), a?Bn(l), and considers braid pair (x?,x) as a public key of S, braid a as a private key of S; Signatory S uses hash function h for a message M needing signature to get y=h(M)?Bn(l); generating a braid b?RBn?1?m(l) randomly, then signing the message M with the own private key a and the braid b generated randomly to obtain Sign(M)=a?1byb?1a; a signature verifying party V obtains the public key of S, calculating the message M by employing a system parameter hash function h, obtaining the y=h(M); judging whether sign(M) and y are conjugate or not, if not, sign(M) is an illegal signature, the verification fails; if yes, sign(M) is a legal signature of message M; the present invention avoids the problem of k-CSP in SCSS signature scheme of prior art, and improves the security of signature algorithm and reduces the number of

Abstract: The invention relates to the compound apogossypolone and salts and prodrugs thereof. Apogossypolone functions as an inhibitor of Bcl-2 family proteins. The invention also relates to the use of apogossypolone for inhibiting hyperproliferative cell growth, for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.