Patents by Inventor Jianyong Chen

Jianyong Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090082445
    Abstract: This invention relates to compositions comprising co-crystals of (?)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (?)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
    Type: Application
    Filed: September 30, 2008
    Publication date: March 26, 2009
    Inventors: Shaomeng Wang, Jianyong Chen
  • Publication number: 20080132485
    Abstract: The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
    Type: Application
    Filed: July 11, 2005
    Publication date: June 5, 2008
    Inventors: Shaomeng Wang, Haiying Sun, Zaneta Nikolovksa-Coleska, Chao-Yie Yang, Liang Xu, Naoyuki G. Saito, Jianyong Chen
  • Publication number: 20080021110
    Abstract: This invention relates to relates to methods for producing gossypol acetic acid co-crystals and (?)-gossypol acetic acid co-crystals. The invention also relates to pharmaceutical compositions comprising gossypol acetic acid co-crystals and (?)-gossypol acetic acid co-crystals and the use of gossypol acetic acid co-crystals and (?)-gossypol acetic acid co-crystals for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
    Type: Application
    Filed: March 29, 2007
    Publication date: January 24, 2008
    Applicant: Regents of the University of Michigan
    Inventors: Shaomeng Wang, Jianyong Chen, John Keana, Ming Guo
  • Publication number: 20080021095
    Abstract: The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of XIAP family proteins. In particular, the present invention provides embelin and other XIAP inhibitors and methods of using these compounds as antagonists of the anti-apoptotic effects of XIAP family member proteins. The present invention also provides methods for treating diseases and pathologies (e.g., neoplastic diseases).
    Type: Application
    Filed: March 22, 2005
    Publication date: January 24, 2008
    Inventors: Jianyong Chen, Zaneta Nikolovska-Coleska, Dajun Yang, Shaomeng Wang, Haiying Sun, Liang Xu, Zengjian Hu
  • Publication number: 20070104322
    Abstract: The present invention discloses a digital signature scheme based on braid group conjugacy problem and a verifying method thereof, wherein the signatory S selects three braids x?LBm(l), x??Bn(l), a?Bn(l), and considers braid pair (x?,x) as a public key of S, braid a as a private key of S; Signatory S uses hash function h for a message M needing signature to get y=h(M)?Bn(l); generating a braid b?RBn?1?m(l) randomly, then signing the message M with the own private key a and the braid b generated randomly to obtain Sign(M)=a?1byb?1a; a signature verifying party V obtains the public key of S, calculating the message M by employing a system parameter hash function h, obtaining the y=h(M); judging whether sign(M) and y are conjugate or not, if not, sign(M) is an illegal signature, the verification fails; if yes, sign(M) is a legal signature of message M; the present invention avoids the problem of k-CSP in SCSS signature scheme of prior art, and improves the security of signature algorithm and reduces the number of
    Type: Application
    Filed: November 12, 2004
    Publication date: May 10, 2007
    Inventors: Yong Ding, Jianyong Chen, Zhiwei Peng
  • Publication number: 20060178435
    Abstract: The invention relates to the compound apogossypolone and salts and prodrugs thereof. Apogossypolone functions as an inhibitor of Bcl-2 family proteins. The invention also relates to the use of apogossypolone for inhibiting hyperproliferative cell growth, for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
    Type: Application
    Filed: November 2, 2005
    Publication date: August 10, 2006
    Applicant: The Regents of the University of Michigan
    Inventors: Shaomeng Wang, Jianyong Chen, Zaneta Nikolovska-Coleska, Dajun Yang