Patents by Inventor Jianzhong Ai

Jianzhong Ai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of inverted terminal repeats (ITRS) from adeno-associated virus serotypes 8 and RH.39 in gene therapy vectors
    Patent number: 11926842
    Abstract: In some aspects, the disclosure provides recombinant AAV and nucleic acid constructs having novel inverted terminal repeats (ITRs), cap, and/or rep genes. In some aspects, the disclosure relates to gene transfer methods using rAAVs described herein.
    Type: Grant
    Filed: February 1, 2022
    Date of Patent: March 12, 2024
    Assignee: University of Massachusetts
    Inventors: Guangping Gao, Phillip Tai, Elisabet C. Mandon, Jianzhong Ai
  • PROSTATE TARGETING ADENO-ASSOCIATED VIRUS SEROTYPE VECTORS
    Publication number: 20230073187
    Abstract: The disclosure relates to compositions and methods for rAAV-mediated delivery of a transgene to a subject. In some embodiments, the rAAV transduces the prostate tissue of a subject. In some embodiments, the methods are useful for treatment of prostate disease (e.g., prostatitis, BPH, prostate cancer).
    Type: Application
    Filed: July 19, 2022
    Publication date: March 9, 2023
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Jianzhong Ai, Hong Li, Qiang Wei
  • Prostate-targeting adeno-associated virus serotype vectors
    Patent number: 11426469
    Abstract: The disclosure relates to compositions and methods for rAAV-mediated delivery of a transgene to a subject. In some embodiments, the rAAV transduces the prostate tissue of a subject. In some embodiments, the methods are useful for treatment of prostate disease (e.g., prostatitis, BPH, prostate cancer).
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: August 30, 2022
    Assignee: University of Massachusetts
    Inventors: Guangping Gao, Jianzhong Ai, Hong Li, Qiang Wei
  • USE OF INVERTED TERMINAL REPEATS (ITRS) FROM ADENO-ASSOCIATED VIRUS SEROTYPES 8 AND RH.39 IN GENE THERAPY VECTORS
    Publication number: 20220251602
    Abstract: In some aspects, the disclosure provides recombinant AAV and nucleic acid constructs having novel inverted terminal repeats (ITRs), cap, and/or rep genes. In some aspects, the disclosure relates to gene transfer methods using rAAVs described herein.
    Type: Application
    Filed: February 1, 2022
    Publication date: August 11, 2022
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Phillip Tai, Elisabet C. Mandon, Jianzhong Ai
  • PROSTATE-TARGETING ADENO-ASSOCIATED VIRUS SEROTYPE VECTORS
    Publication number: 20180311380
    Abstract: The disclosure relates to compositions and methods for rAAV-mediated delivery of a transgene to a subject. In some embodiments, the rAAV transduces the prostate tissue of a subject. In some embodiments, the methods are useful for treatment of prostate disease (e.g., prostatitis, BPH, prostate cancer).
    Type: Application
    Filed: October 21, 2016
    Publication date: November 1, 2018
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Jianzhong Ai, Hong Li, Qiang Wei