Abstract: The present invention relates to methods and compositions for treating an LRRK2-associate disorder or condition, e.g., Parkinson's Disease, methods for reducing or preventing neuronal cell death, and methods for reducing neurodegeneration and/or neuroinflammation, in a subject in need thereof, by an agent that decreases the expression of LRRK2, e.g., an agent that induces LRRK2 mRNA decay.

Abstract: Providing a multi-functional group superplasticizer for an ultra-high performance concrete and a method for preparing the same. Its backbone is an alkyl chain, and its side chain are some side chains with carboxylic acid or carboxylate at terminals, some polyether side chains, and some polyol amine side chains substituted with phosphoric acid or phosphite at terminals, the polyol amine side chains substituted with phosphoric acid or phosphite at terminals is connected to the backbone through a phenyl or an alkyl group of 1-9 carbons, and a ratio of a number of the side chains with carboxylic acid or carboxylate at terminals to a total number of side chains is ?0 and ?0.8; and a ratio of a number of the polyether side chains to the total number of side chains is ?0.1 and ?0.9.

Abstract: According to various embodiments of the present disclosure, an electronic device analyzes shared contents of all members in a circle created by a client user and generates feature information of the circle. The electronic device analyzes shared contents of each member in a buddy list created by the client user and generates feature information of each member in the buddy list. The electronic device calculates a similarity between the feature information of each member in the buddy list and the feature information of the circle, generates a similarity set, and generates a recommended buddy of the circle based on the similarity set. The electronic device prompts the recommended buddy of the circle to the client user.

Abstract: According to various embodiments of the present disclosure, an electronic device analyzes shared contents of all members in a circle created by a client user and generates feature information of the circle. The electronic device analyzes shared contents of each member in a buddy list created by the client user and generates feature information of each member in the buddy list. The electronic device calculates a similarity between the feature information of each member in the buddy list and the feature information of the circle, generates a similarity set, and generates a recommended buddy of the circle based on the similarity set. The electronic device prompts the recommended buddy of the circle to the client user.

Abstract: Disclosed is an automatic sunlight tracking device comprising a solar panel holder (1), a mounting (2), a pitching angle tracking member, and a swing angle tracking member. The solar panel holder (1) is coupled with the mounting (2) through a three-dimensional assembly (3), and the pitching tracking member comprises a first transmission part and a first drive device (81) cooperating with the first transmission part. The swing tracking member comprises a second transmission part and a second drive device (82) cooperating with the second transmission part. The three-dimensional assembly (3) includes two rotation supporting shafts arranged in a cross shape. The automatic sunlight tracking device has a high operation accuracy, a reasonable structure, low operation energy consumption. It is easy to be controlled, and installation and maintenance is facilitated.

Abstract: Disclosed is an automatic sunlight tracking device comprising a solar panel holder (1), a mounting (2), a pitching angle tracking member, and a swing angle tracking member. The solar panel holder (1) is coupled with the mounting (2) through a three-dimensional assembly (3), and the pitching tracking member comprises a first transmission part and a first drive device (81) cooperating with the first transmission part. The swing tracking member comprises a second transmission part and a second drive device (82) cooperating with the second transmission part. The three-dimensional assembly (3) includes two rotation supporting shafts arranged in a cross shape. The automatic sunlight tracking device has a high operation accuracy, a reasonable structure, low operation energy consumption. It is easy to be controlled, and installation and maintenance is facilitated.

Abstract: The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudoviruses (VLPs with plasmids inside). Oral administration of the pseudoviruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudovirus induces stronger immune response than DNA vaccines. Additionally, the pseudovirus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.

Abstract: The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudoviruses (VLPs with plasmids inside). Oral administration of the pseudoviruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudovirus induces stronger immune response than DNA vaccines. Additionally, the pseudovirus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.

Abstract: The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudoviruses (VLPs with plasmids inside). Oral administration of the pseudoviruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudovirus induces stronger immune response than DNA vaccines. Additionally, the pseudovirus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.

Abstract: The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudoviruses (VLPs with plasmids inside). Oral administration of the pseudoviruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudovirus induces stronger immune response than DNA vaccines. Additionally, the pseudovirus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.

Abstract: The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudoviruses (VLPs with plasmids inside). Oral administration of the pseudoviruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudovirus induces stronger immune response than DNA vaccines. Additionally, the pseudovirus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.

Abstract: The invention involves a papilloma pseudo-virus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudo-virus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudo-viruses (VLPs with plasmids inside). Oral administration of the pseudo-viruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudo-virus induces stronger immune response than DNA vaccines. Additionally, the pseudo-virus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.

Abstract: The invention involves a papilloma pseudo-virus that can induce immune response after oral intake as well as its preparation. It characterizes that: the HPV or BPV pseudo-virus made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), reassembled into pseudo-virus (VLPs with plasmids inside). The pseudo-virus can be orally given, entering mucosa and systemic lymphoid tissues of human body, activate immune system and serve as treating and preventing agent. The pseudo-virus can induce stronger immune response than DNA vaccines. Additionally, the pseudo-virus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in human body.