Patents by Inventor Jianzhuang YAO

Jianzhuang YAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cocaine esterase mutant and use thereof
    Patent number: 12180519
    Abstract: Disclosed are a cocaine esterase mutant and use thereof. The cocaine esterase mutant is obtained by mutating a wildtype cocaine esterase, an amino acid sequence of the wildtype cocaine esterase is shown as SEQ ID No. 1, the cocaine esterase mutant is T172R/G173Q/L196C/I301C, or additionally added with V116K point mutation, or additionally added with A51 site mutation, and the A51 site mutation is L, Y, V, F or W. Catalytic efficiency of the cocaine esterase mutant screened on a cocaine toxic metabolite benzoylecgonine is greatly improved compared with that of a wildtype enzyme.
    Type: Grant
    Filed: October 18, 2023
    Date of Patent: December 31, 2024
    Assignee: Hangzhou Normal University
    Inventors: Xiabin Chen, Jianzhuang Yao, Shurong Hou, Xingyu Deng, Yun Zhang, Junsen Tong
  • COCAINE ESTERASE MUTANT AND USE THEREOF
    Publication number: 20240117329
    Abstract: Disclosed are a cocaine esterase mutant and use thereof. The cocaine esterase mutant is obtained by mutating a wildtype cocaine esterase, an amino acid sequence of the wildtype cocaine esterase is shown as SEQ ID No.1, the cocaine esterase mutant is T172R/G173Q/L196C/I301C, or additionally added with V116K point mutation, or additionally added with A51 site mutation, and the A51 site mutation is L, Y, V, F or W. Catalytic efficiency of the cocaine esterase mutant screened on a cocaine toxic metabolite benzoylecgonine is greatly improved compared with that of a wildtype enzyme.
    Type: Application
    Filed: October 18, 2023
    Publication date: April 11, 2024
    Inventors: Xiabin CHEN, Jianzhuang YAO, Shurong HOU, Xingyu DENG, Yun ZHANG, Junsen TONG