Abstract: Disclosed in the present invention is an antibody-drug conjugate of a novel Exatecan analogue, a pharmaceutical composition containing the conjugate, and a medical use of the conjugate and the pharmaceutical composition. The novel Exatecan analogue of the present invention has very strong tumour inhibition efficiency, and the provided TROP-2 antibody-drug conjugate and HER3 antibody-drug conjugate have good tumour inhibition effects and good prospects for clinical application.

Abstract: Provided are an antibody having effective neutralizing activity against RSV or an antigen-binding fragment thereof. The provided anti-RSV antibody or antigen-binding fragment thereof can be used as a drug for treating or preventing RSV infection or symptoms related to RSV infection. The provided RSV antibody, after humanization, can bind RSV-F protein with high affinity. In addition, experiments show that it is significantly better than palivizumab at providing protection against RSV challenge.

Abstract: The present invention relates to a pharmaceutical combination comprising a PCSK9 inhibitor and a GLP-1 receptor agonist; The invention also relates to the use of the pharmaceutical combination in preparing drugs for treating hyperglycemia, diabetes, obesity and/or cholesterol related diseases.

Abstract: The present invention relates to a bispecific chimeric antigen receptor, which can target both CD19 and CD22 proteins. T cells expressing the chimeric antigen receptor have good killing effect on tumor cells expressing CD19 and/or CD22 proteins. The chimeric antigen receptor of the present invention can realize a good killing effect on tumor cells with loss of CD19, and provides a more effective therapeutic way for tumor diseases.

Abstract: A leg-protecting apparatus is arranged in close contact with a body surface of a wearer to cover a thigh, a knee, and a calf of the wearer, including a biomechanically protecting strap arranged to correspond with structural locations and paths of tendons and ligaments of the knee and muscles proximal thereto during an exercise process. The strap comprises a cruciate ligament protecting strap, a patellar tendon protecting strap, a thigh muscle group protecting strap, and a calf muscle group protecting strap. Elastic moduli of the cruciate ligament protecting strap and the patellar tendon protecting strap has a step-change upon a change in a fabric tensile ratio caused by the knee bending of the wearer, wherein the step-change occurs after an initial low tensile modulus stage, during a tensile sudden-change stage, and before a high tensile modulus stage transitioning between the stages as knee angle decreases.

Abstract: A dynamic elastic one-way water-guiding sportswear is formed from a basic cloth. The basic cloth is made from a porous material having capable of dynamically adsorbing and transferring liquid water, and the dynamic transferring and guiding capability for liquid water of the basic cloth is determined based on the stretching ratio of the covered skin. The sportswear comprises an elastic stretchable bands (1_1, 1_2) and a pressure fastening area (2), wherein the elastic stretchable bands (1_1, 1_2) and the pressure fastening area (2) have different mechanics transmission properties. The elastic stretchable bands (1_1, 1_2) are used to provide elastic protection for twisting and stretching driven by the shoulders and legs, and the pressure fastening area (2) is used to fasten and protect the soft tissues of the back and abdomen by providing a pressure thereupon.

Abstract: A leg-protecting apparatus is arranged in close contact with a body surface of a wearer to cover a thigh, a knee, and a calf of the wearer, including a biomechanically protecting strap (A) arranged to correspond with structural locations and paths of tendons and ligaments of the knee and muscles proximal thereto during an exercise process. The strap comprises a cruciate ligament protecting strap (A-1), a patellar tendon protecting strap (A-2), a thigh muscle group protecting strap (A-3), and a calf muscle group protecting strap (A-4). Elastic moduli of the cruciate ligament protecting strap (A-1) and the patellar tendon protecting strap (A-2) has a step-change upon a change in a fabric tensile ratio caused by the knee bending of the wearer, wherein the step-change occurs after an initial low tensile modulus stage, during a tensile sudden-change stage, and before a high tensile modulus stage transitioning between the stages as knee angle decreases.

Abstract: The present invention discloses a gasoline efficacy promoter (GEP) boosting combustion efficiency of gasoline in internal combustion engines by a mechanism of micro-dissociation comprising a microemulsion of modified bio-carbon, a surfactant, water, a modified vegetable oil and a dispersant, and a method of making it. The gasoline efficacy promoter, environmentally friendly and stable for longer than six months, can increase the combustion efficiency by more than 10%, and reduce 80% of NOx formation in exhaust emission when an appropriate dosage is added to a fuel tank in a vehicle.

Abstract: The present invention discloses a gasoline efficacy promoter (GEP) boosting combustion efficiency of gasoline in internal combustion engines by a mechanism of micro-dissociation comprising a microemulsion of modified bio-carbon, a surfactant, water, a modified vegetable oil and a dispersant, and a method of making it. The gasoline efficacy promoter, environmentally friendly and stable for longer than six months, can increase the combustion efficiency by more than 10%, and reduce 80% of NOx formation in exhaust emission when an appropriate dosage is added to a fuel tank in a vehicle.

Abstract: The present invention relates to a biocompatible material and in particular to a two-phase or composite biocompatible ceramic material, wherein the first phase is a doped calcium zinc silicate and the second phase is a metal oxide. In an embodiment, the invention has been developed for use in tissue regeneration including bone tissue. In other embodiments, the invention has been developed as a coating to improve the long-term stability of prior art implantable medical devices.

Abstract: A method predicts power flow in a distributed generation network of at least one distributed generator and at least one co-generator, where the network is defined by a plurality of network nonlinear equations. The method includes applying an iterative method to the plurality of network nonlinear equations to achieve a divergence from a power flow solution to the plurality of network nonlinear equations. The method also includes applying the iterative method to find a first solution to a plurality of simplified nonlinear equations homotopically related by parameterized power flow equations to the plurality of network nonlinear equations. The method further includes iteratively applying the iterative method to the parameterized power flow equations starting with the first solution to achieve the power flow solution to the plurality of network nonlinear equations.

Abstract: The present invention relates to a biocompatible material and in particular to a two-phase or composite biocompatible ceramic material, wherein the first phase is a doped calcium zinc silicate and the second phase is a metal oxide. In an embodiment, the invention has been developed for use in tissue regeneration including bone tissue. In other embodiments, the invention has been developed as a coating to improve the long-term stability of prior art implantable medical devices.