Abstract: Display panel and display device are provided. The display panel includes a plurality of subpixels. A subpixel of the plurality of subpixels includes a pixel circuit and a light emitting element that are electrically connected. The pixel circuit includes a first transistor. A first electrode of the first transistor is connected to a first reference voltage signal terminal. A second electrode of the first transistor is electrically connected to an anode of the light emitting element. In a light emitting retention stage of the subpixel of the plurality of subpixels, the first reference voltage signal terminal is connected to a negative potential signal or a ground potential signal. The plurality of subpixels includes at least a first subpixel and a second subpixel, and a color of the first subpixel is different from a color of the second subpixel.

Abstract: Human skeletal muscle stem cells were generated from facioscapulohumeral muscular dystrophy (FSHD) and healthy control iPSC using a transgene-free skeletal muscle differentiation protocol and production of stable iMyoblasts. Analyses revealed that FSHD and healthy control iMyoblasts are embryonic-like myogenic cells that undergo myotube differentiation ex vivo by growth factor depletion and are efficiently transplantable into the tibialis anterior (TA) muscles of NSG mice, where human muscle under-goes embryonic-to-adult myosin isoform switching. The DUX4 FSHD disease gene maintains its hypomethylated disease state inFSHD iPSC and iMyoblast, and its expression is upregulated during myotube differentiation and in muscle xenografts. Consequently, these iMyoblasts accurately exhibit the molecular pathology of human muscular dystrophies and are useful for the development of drug, gene editing and stem cell therapeutics.

Abstract: Display panel and display device are provided. The display panel includes a plurality of subpixels. A subpixel of the plurality of subpixels includes a pixel circuit and a light emitting element that are electrically connected. The pixel circuit includes a first transistor. A first electrode of the first transistor is connected to a first reference voltage signal terminal. A second electrode of the first transistor is electrically connected to an anode of the light emitting element. In a light emitting retention stage of the subpixel of the plurality of subpixels, the first reference voltage signal terminal is connected to a negative potential signal or a ground potential signal. The plurality of subpixels includes at least a first subpixel and a second subpixel, and a color of the first subpixel is different from a color of the second subpixel.

Abstract: The present invention provides an improved method of producing highly pure retinal pigment epithelial (RPE) cells by differentiation of pluripotent stem cells.