Abstract: The present disclosure provides a carbide refining method of a high-carbon high-alloy steel. The carbide refining method of a high-carbon high-alloy steel includes the following steps: formulating a raw material according to chemical element compositions of the high-carbon high-alloy steel, and smelting to obtain a high-carbon high-alloy molten steel; performing an overheat treatment on the high-carbon high-alloy molten steel to Tm+(50˜100)° C., to obtain a high-carbon high-alloy melt, and making the high-carbon high-alloy melt to be deposited in a preset water-cooled copper mold at a speed of 30˜160 g/s by an inert gas, to obtain a high-carbon high-alloy billet through solidification molding; and performing a heat treatment process on the high-carbon high-alloy billet.

Abstract: The present invention provides an antibody binding a human tumor-associated calcium signal sensor 2 (Trop-2) protein or fragments thereof, and use of the antibody or fragments thereof in preventing or treating diseases. The antibody or fragments thereof of the present invention can effectively bind to the human Trop-2 protein, and have internalization activity, and the internalization activity is enhanced after ADC drug labeling, and the in vivo efficacy and safety of a mouse model are not lower than those of a control antibody.

Abstract: The present invention discloses a preparation method for a metal material, including: horizontally placing a to-be-prepared metal material between wavy surfaces of a female die and a male die; connecting a press machine with the male die; pressing the metal material through the male die, so that the metal material makes complete contact with the male die and the female die; ejecting the pressed metal material; horizontally overturning the metal material, and then placing the metal material between the wavy surfaces of the female die and the male die; repeatedly performing the pressing and overturning processes until accumulated strain of the metal material meets a requirement; and taking out the metal material after the deformed metal material is flattened by a plane die. According to the present invention, a large-size nano grained material can be manufactured.

Abstract: An aerosol-generating apparatus is provided. The aerosol-generating apparatus includes a heating base and a heating member. The heating base has a heating cavity, the heating member is configured to accommodate and heat an aerosol-generating substrate, the heating member is disposed in the heating cavity. The heating member includes a first sidewall, a first airflow channel is formed between the first sidewall and the inner surface of the heating cavity. A protrusion is disposed on an inner surface of the first sidewall, the protrusion makes a second airflow channel formed between the first sidewall and the aerosol-generating substrate, and both the first airflow channel and the second airflow channel are led from the outside of the aerosol-generating apparatus to the bottom of the heating cavity.

Abstract: Provided are an antibody and a preparation method therefor. The antibody is, such as a humanized anti-human CD47 monoclonal antibody or fragment thereof, and a bispecific antibody targeting PD-L1 and CD47 or an antigen-binding fragment thereof. The bispecific antibody comprises two heavy chains and two light chains, variable regions of the two heavy chains are heterologous, and variable regions of the two light chains have similar sequences. The provided bispecific antibody has the light chains having the similar sequences, thus solving the technical problem of light and heavy chain mismatch during an assembly process of bispecific antibodies.

Abstract: A multi-physical field measurement device for a metal solidification process and a housing and a measurement method thereof are provided. The device includes: a sealed housing provided with a light-through hole; a heater provided inside the housing and located behind the light-through hole along an X-ray; a diffraction detector used for receiving the X-ray which penetrates through a sample sheet and is scattered; a CMOS camera located behind the heater along the X-ray (11) and used for receiving a visible light signal which penetrates through the sample sheet; a silicon drift X-ray detector located at one side of the X-ray and used for receiving a fluorescent signal sent by interaction between the X-ray and the sample piece sheet; and an infrared thermal imager located at the other side of the X-ray and used for receiving an infrared signal sent by the sample sheet.

Abstract: An approach is provided in which the approach captures a first user activity log of a first user accessing multiple systems and captures a set of second user activity logs of a set of second users accessing the multiple systems. The approach determines a set of system monitoring preferences based the first user activity log and the set of second user activity logs, and scores the multiple systems based on the set of system monitoring preferences. The approach generates a recommended system monitoring list based on the scored multiple systems, and transmits the recommended system monitoring list to the first user.

Abstract: A method and apparatus for manufacturing an equiaxed crystal aluminum alloy cast ingot by using additive manufacturing and rapid solidification techniques are provided. The apparatus comprises: a metal heating mechanism and a negative pressure cooling mechanism. The metal heating mechanism is located above the negative pressure cooling mechanism and is connected thereto by a nozzle. The negative pressure cooling mechanism comprises a vacuum chamber having an air inlet hole and an air outlet hole, and a three-dimensional moving ingot mechanism disposed inside the vacuum chamber. The three-dimensional moving ingot mechanism comprises a moving ingot and a two-dimensional moving platform vertically connected to the moving ingot. A water cooling mechanism is disposed outside the moving ingot, and the moving ingot is driven by a precision motor to precisely move up and down.

Abstract: An embodiment includes detecting an interface element and an element attribute of the interface element in a series of views of a user interface, and then after an update of the user interface, detecting a candidate element and a candidate element attribute in a series of views of the updated user interface. The embodiment then determines that the updated user interface lacks any errors using a decision tree that includes comparisons of all interface elements of the user interface to corresponding candidate elements of the updated user interface. The embodiment then generates an optimized decision tree based at least in part on an analysis of the comparisons of the user interface to the updated user interface resulting in a condition that allows for the determining of a lack of errors based on comparisons of a subset of the interface elements to corresponding candidate elements.

Abstract: An approach is provided in which the approach captures a first user activity log of a first user accessing multiple systems and captures a set of second user activity logs of a set of second users accessing the multiple systems. The approach determines a set of system monitoring preferences based the first user activity log and the set of second user activity logs, and scores the multiple systems based on the set of system monitoring preferences. The approach generates a recommended system monitoring list based on the scored multiple systems, and transmits the recommended system monitoring list to the first user.

Abstract: A heating assembly includes: a heating element having a substrate and a heating region, an overlapping region and a conductive region being located on the substrate and sequentially distributed in an axial direction of the substrate and connected, the heating region being provided with a heating circuit which extends to the overlapping region, and the conductive region being provided with a conductive circuit which extends to the overlapping region and is connected with the heating circuit in an overlapping manner or in parallel; and a fixing base, one end of the fixing base fixing the heating element, the fixing base being at least partially in contact with the overlapping region.

Abstract: The present invention discloses a preparation method for a metal material, including: horizontally placing a to-be-prepared metal material between wavy surfaces of a female die and a male die; connecting a press machine with the male die; pressing the metal material through the male die, so that the metal material makes complete contact with the male die and the female die; ejecting the pressed metal material; horizontally overturning the metal material, and then placing the metal material between the wavy surfaces of the female die and the male die; repeatedly performing the pressing and overturning processes until accumulated strain of the metal material meets a requirement; and taking out the metal material after the deformed metal material is flattened by a plane die. According to the present invention, a large-size nano grained material can be manufactured.

Abstract: An array-spraying additive manufacturing apparatus and method for manufacturing a large-sized equiaxed crystal aluminum alloy ingot, comprising: a liquid aluminum spraying mechanism having array nozzles disposed in an atmospheric pressure chamber, a movable condensing mechanism disposed in the atmospheric pressure chamber below the liquid aluminum spraying mechanism, and a control mechanism. The control mechanism sends an upward guiding command to a release mechanism and issues a three-dimensional movement command to the movable condensing mechanism, such that liquid aluminum in the liquid aluminum spraying mechanism is sprayed at the surface of the movable condensing mechanism in a continuous array of liquid flows according to a preset path and is rapidly condensed to form an ingot. Also disclosed is an additive manufacturing method employing the apparatus.

Abstract: An aerosol generation substrate includes: a main body for generating aerosol after being heated, magnetic particles being distributed in the main body, the magnetic particles generating heat through electromagnetic induction to heat the main body; and a cooling member sleeved on the main body and for assisting in cooling of the main body.

Abstract: A baked item includes a tobacco and a microwave absorbing agent. The tobacco and the microwave absorbing agent are both capable of absorbing microwaves to generate heat, the microwave absorbing agent is made of a non-volatile solid material with a stable dielectric loss constant. The microwave absorbing agent is capable of stably absorbing microwaves to generate heat to heat the tobacco through thermal conduction. A method for preparing the baked item and a microwave heating method for the baked item include, the microwave absorbing agent is added into the tobacco, and the microwave absorbing agent can stably absorb microwaves to generate heat. In addition to absorbing microwaves to generate heat, the tobacco may be also heated by the microwave absorbing agent through thermal conduction, and temperature rising of the tobacco is more stable and uniform under a double heating mechanism of microwave radiation and thermal conduction.

Abstract: A cigarette device includes a housing, and a loading cavity, an airflow sensor, a circuit control unit, and a power supply are disposed in the housing. A fluid channel is located between the loading cavity and the housing, and the fluid channel is in communication with the outside of the housing and the inside of the loading cavity. An electromagnetic induction heating element surrounds the outside of the loading cavity; and the electromagnetic induction heating element is electrically connected to the power supply, and the circuit control unit is electrically connected to the airflow sensor and the electromagnetic induction heating element. When the cigarette device is used in combination with a cigarette added with a magnetic material, the cigarette can be heated uniformly and generate vapor quickly, to ensure a consistent vaping taste and improve utilization of tobacco while achieving immediate vaping and immediate stopping, which helps improve user experience.

Abstract: The invention provides a method for initial alignment of radar assisted airborne strapdown inertial navigation system. By calculating the slant distance and angular position between the radar and the airborne inertial navigation equipment, a nonlinear measurement equation for the initial alignment of the radar assisted inertial navigation system is obtained. The unscented Kalman filter algorithm is used to estimate and compensate the error amount of strapdown inertial navigation system to complete the initial alignment task. The significance of the present invention is to provide an in-flight initial alignment solution when the global positioning system is limited, which has fast convergence speed and high estimation accuracy and has high engineering application value.

Abstract: Disclosed are a nucleic acid-drug conjugate based on a phosphorothioate-modified nucleic acid, a drug delivery system, and a preparation method therefor. The nucleic acid-drug conjugate is formed by reacting and conjugating a phosphorothioate group in a phosphorothioate-modified nucleic acid with a group that is modified on a drug molecule and able to undergo electrophilic reaction with the phosphorothioate groups; in addition, by selecting different nucleic acid sequences including functional nucleic acids, the nucleic acid-drug conjugate is able to be self-assembled into various forms of drug-containing nano-carriers for drug delivery.

Abstract: An array-spraying additive manufacturing apparatus and method for manufacturing a large-sized equiaxed crystal aluminum alloy ingot, comprising: a liquid aluminum spraying mechanism having array nozzles disposed in an atmospheric pressure chamber, a movable condensing mechanism disposed in the atmospheric pressure chamber below the liquid aluminum spraying mechanism, and a control mechanism. The control mechanism sends an upward guiding command to a release mechanism and issues a three-dimensional movement command to the movable condensing mechanism, such that liquid aluminum in the liquid aluminum spraying mechanism is sprayed at the surface of the movable condensing mechanism in a continuous array of liquid flows according to a preset path and is rapidly condensed to form an ingot. Also disclosed is an additive manufacturing method employing the apparatus.

Abstract: A method and apparatus for manufacturing an equiaxed crystal aluminum alloy cast ingot by using additive manufacturing and rapid solidification techniques are provided. The apparatus comprises: a metal heating mechanism and a negative pressure cooling mechanism. The metal heating mechanism is located above the negative pressure cooling mechanism and is connected thereto by a nozzle. The negative pressure cooling mechanism comprises a vacuum chamber having an air inlet hole and an air outlet hole, and a three-dimensional moving ingot mechanism disposed inside the vacuum chamber. The three-dimensional moving ingot mechanism comprises a moving ingot and a two-dimensional moving platform vertically connected to the moving ingot. A water cooling mechanism is disposed outside the moving ingot, and the moving ingot is driven by a precision motor to precisely move up and down.