Patents by Inventor Jiaole FANG

Jiaole FANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Daptomycin-producing Streptomyces strain and use thereof
    Patent number: 11884952
    Abstract: The present invention provides a novel daptomycin-producing Streptomyces strain and use thereof, the strain is a subspecies of streptomyces griseus, named Streptomyces griseus L340, and the preservation number is CGMCC17921. The genetic character and fermentation unit of the strain provided by the present invention are relatively stable, the culture and fermentation conditions are suitable for industrial production of daptomycin, and the interference of pigment in later separation and purification is eliminated. The secondary metabolite daptomycin is obtained through fermentation of the Streptomyces provided by the present invention, which has the advantages of no interference of pigment accumulation, cleaner metabolic spectrum and thus is obviously superior in later separation and purification.
    Type: Grant
    Filed: April 21, 2020
    Date of Patent: January 30, 2024
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Yongquan Li, Jiaole Fang, Xuming Mao, Xinai Chen
  • NOVEL DAPTOMYCIN-PRODUCING STREPTOMYCES STRAIN AND USE THEREOF
    Publication number: 20230118242
    Abstract: The present invention provides a novel daptomycin-producing Streptomyces strain and use thereof, the strain is a subspecies of streptomyces griseus, named Streptomyces griseus L340, and the preservation number is CGMCC17921. The genetic character and fermentation unit of the strain provided by the present invention are relatively stable, the culture and fermentation conditions are suitable for industrial production of daptomycin, and the interference of pigment in later separation and purification is eliminated. The secondary metabolite daptomycin is obtained through fermentation of the Streptomyces provided by the present invention, which has the advantages of no interference of pigment accumulation, cleaner metabolic spectrum and thus is obviously superior in later separation and purification.
    Type: Application
    Filed: April 21, 2020
    Publication date: April 20, 2023
    Inventors: Yongquan LI, Jiaole FANG, Xuming MAO, Xinai CHEN